Search Results

That choice determines whether you risk over- or under-dosing, miss safety windows, or miss therapeutic In this session, you’ll gain: ✅Clarity on Definitions:  What truly distinguishes orthosteric from allosteric

In this session, you’ll gain: ✅ A mental model you can trust  for predicting how GPCR ligands behave

Mandibulofacial dysostosis with alopecia results from ETAR gain-of-function mutations via allosteric

As a Premium Member, you gain exclusive access to this incredible treasure trove we've amassed over the

ERK activation pathways can be categorised into two main sub-pathways based on their subcellular localisation The choice of pathway can result in different cellular responses, underscoring the criticality of precise

remaining non-sensory receptors, with functions more readily linked to pathology, are currently the main cell surface, or because they have an enhanced capacity to elicit receptor internalization, thereby gaining 17706–17711. https://doi.org/10.1073/pnas.0805098105 · Development and use of new technology to gain

The G-protein-coupled receptors in the human genome form five main families.

Subscribe now to gain access to exclusive insights from Dr. GPCR Newsletter!

In this lesson, you'll gain: ✅ Clarity on what “irreversible” really means  in kinetic and pharmacologic It’s a design space , not a binary choice, and penetration is just the beginning.

Hoare's expert guidance, you will gain invaluable skills in data analysis.

This concept is gaining significant attention in drug discovery, especially in the context of G protein-coupled

In this course, you’ll gain: ✅ How assay volume control  alters receptor sensitivity and what that

GPCR Newsletter to gain access to further insights!

In This Session, You’ll Gain: ✅ How to turn descriptive snapshots into predictive insights ✅ Tools to What looked like four conflicting behaviors turned out to be one coherent mechanism , hidden in plain Unlock “Mechanism of Action” now Only in Terry’s Corner   Why Terry’s Corner When early choices determine

animals — a milestone that demonstrated just how powerful well-engineered chemical tools can be when paired JB gained a grounded understanding of tissue heterogeneity, signal variability, and the biology that

Gain access to over 500 minutes of recorded classes in our  GPCR courses   taught by Drs.

In this session, you’ll gain: Why saturation and displacement assays fail when protein stoichiometry

In this session, you’ll gain: How system sensitivity transforms potency, efficacy, and agonist classification

His introduction came through a practical suggestion: explore a new protein family that was gaining traction

Dive into this fascinating topic and gain valuable insights from one of the leading experts in the field

Allosteric modulation is gaining prominence in GPCR therapeutics, with the discovery of an intracellular

Non-Radioactive Workflow By removing isotopes, researchers gain safer, more scalable, and more environmentally

These painstaking manual workflows laid the foundation for what would become the evolution of GPCR research

electrophysiology platform, iPSC-derived models, optogenetics, and high-content screening techniques such as cell painting

Cy3B label of CELT-419, which fits well for FA and live-cell microscopy measurements, is not the best choice An Order of Magnitude Faster DNA-PAINT Imaging by Optimized Sequence Design and Buffer Conditions.

In the cardiovascular system, ORs have the potential to operate as the main carriers of endogenously

think batteries and balance scales), Terry reveals why different tissues—and even different assays—can paint

The future According to the authors, the future of AI relies in 6 main areas: 1.