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GIP has been linked to the pathogenesis of diabetes mellitus, and our analyses suggest a potential link

Our study provides mechanistic insights into the regulation of aGPCRs via post-translational modifications

Our results revealed that GB83 is a bona fide agonist of PAR2 that uniquely modulates PAR2-mediated cellular

including the first small molecule positive allosteric modulator of CB2 receptors, has greatly advanced our

This Week’s Highlights: Congrats to: John Teye Azietaku , our great contributor, for his article Class

Discover our comprehensive coverage of GPCRs, We welcome GPCR paper suggestions! Our Chief Matchmaker, Mark Schmeizl, is here to assist you.

the 2022 Benjamin Franklin Medal in Chemistry from The Franklin Institute "Huge congratulations to our

Let's gather 'round for our weekly dose of GPCR News. Congratulations to our Dr.

Our previous study indicated that ARBB1 (arrestin beta 1) promotes hepatocellular carcinogenesis (HCC Our results demonstrate that ARRB1 plays a critical role in HBV-related HCC via modulating autophagy

Our findings suggest a positive feedback loop in which Wnt-stimulated local PI(4,5)P2 production enhances

In summary, our study shows that inhibiting homodimerization has a setmelanotide-like effect on Gq/11

Together, our results provide a comprehensive experimental characterization of the proteostatic properties

June 2022 "We’re delighted to welcome Dr Ed Brennan as our new Vice President, Head of Clinical Development

Our CSO, Maria, has recently traveled to the US to attend the ACSMEDI-EFMC Medicinal Chemistry Frontiers

Check out our latest collection of 25 cutting-edge research papers on GPCRs and exciting updates on industry We're thrilled to announce the dates for our upcoming courses led by the renowned Dr.

Taken together, our study fills the missing information of GPCR/G-protein engagement and provides a framework

Our observations with these prominent commonalities may provide new insights into the phenotype and characteristics

Our data support the idea of a modulatory role of anosmin 1 in the biological effects controlled by the

Studies about the Gα protein coupling bias of mutant AVPR2s may broaden our understanding of the relationship

Check out our curated GPCR coverage for this week, which includes 14 GPCR papers, four industry news, GPCR University Our first Dr.

Our study demonstrates the importance of β-catenin lysine methylation in terms of its sustained expression

Warm greetings and a resounding welcome back to our GPCR Weekly Newsletter, rejuvenated after the festive GPCR Ecosystem contents and perks, including our forums, private groups, and all Ecosystem members Go

These techniques not only enhance our understanding of fundamental cellular processes, but also hold As technology continues to advance, leveraging RET-based sensors will undoubtedly continue to propel our

In a proof-of-principle study, we succeeded in showing that our CCR9-PROTAC is able to reduce CCR9 levels

Our results demonstrated that THC and CBD reduced cellular viability at concentrations above 30μM and

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Watch our new trailers for a preview of expert-led GPCR training designed for scientists and drug hunters Access this week’s full Premium Edition here ➤ What our members say "This came at just the most perfect

Together, our data support that activation of cGAS/STING signaling mitigates organ fibrosis and suppresses