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After years of living with unresolved pain following surgery for a pilonidal cyst, Alex was left without This is a story about how chronic pain doesn't just shape lives — it reshapes careers. The Value of Lived Experience in Science What makes Serafini’s trajectory so compelling isn’t just his His interest in model development, in capturing the lived human experience through preclinical systems He’s focused on RGS proteins , pain comorbidities  like addiction and depression, and pushing for more

By considering factors like the Langmuir adsorption isotherm and binding curves, researchers can better

These ongoing conversations keep me on the front lines, sharpening my understanding of the common bottlenecks

recovering from a stall, I’ll help you move faster—with fewer blind spots, tighter execution, and a clear line

But Sokhom Pin stayed loyal to GPCRs , even when big pharma turned its gaze to other targets like kinases High-throughput screening for receptor ligands was booming, and Sokhom was at the center of it.

just credentials He designed lab workflows that encouraged curiosity without burnout He supported work-life In a field like GPCR research (where data complexity and failure rates are high), scientific rigor thrives Alkermes didn’t just improve drug screening outcomes, it redefined what great leadership in biotech looks like

As a lab technician at Johns Hopkins, he was fascinated by science but also grounded in real-life responsibilities Takeaway If you’re navigating work, life, and scientific ambition, Sokhom Pin proves it’s possible to

Welcome Back, Discovery Drivers   Terry’s Corner is live, on-demand pharmacology built for drug discovery Dr.GPCR Updates Terry’s Corner is Live - Pharmacology at your fingertips Terry’s Corner is now open! Join Terry’s Corner Today Yamina’s Corner Is Live – Are you drowning in disorganized data? GPCR partner Celtarys Research has validated a TR-FRET assay for cannabinoid receptor ligands using their Distinct Ligand Activation in NMBR Simulations show how two ligands differently activate class A GPCR

Eli Lilly’s next moves with Orforglipron and its amylin analog are highly anticipated.   Plus, Celtarys explores ligand selection for better assays, and co-founder Dr. Maria Majellaro shares her story of innovation and listening-driven science.   Sign Up for The Kenakin Brief Fluorescent Ligands vs. Radioligands – Assay Smarter Celtarys explores how fluorescent ligands enable safer, high-throughput

Ever wondered why a drug behaves like a miracle in one tissue and a dud in another?

What happens between identifying a target and delivering a life-saving treatment? In this foundational-level  lesson, Terry unpacks the real-life process behind discovering new drugs,

Maria Majellaro makes it clear that Celtarys isn’t just a ligand provider. Maria Majellaro Celtarys specializes in the custom development of fluorescent ligands  using a modular Their method allows researchers to explore different linker positions, tailor activity (agonist or antagonist Maria emphasizes the importance of genuinely listening to researchers: understanding the biological question discovery workflow on the company page . _______________ Keyword Cloud:   GPCR data platform , fluorescent ligands

re early in your career or pushing the edge of MoA design, weekly lesson help you apply key concepts like The Corner comes will live monthly AMA sessions with Dr. Kenakin. Binding Assays Across Platforms   Celtarys Research presents CELT-419, a nanomolar-affinity fluorescent ligand optimized for D3 receptor assays in both baculovirus and live-cell systems. GPCR mutations in cancer   show both driver-like patterns and high redundancy, prompting a call for multiomics

Watch Episode 168 Success in science is rarely linear. Maria Majellaro Now, she leads a team of talented chemists at Celtarys, developing fluorescent ligands company page . _______________ Keyword Cloud:   GPCR scientist network , career development , fluorescent ligands

Maria worked with had developed a technology that allowed for flexible, fast synthesis of fluorescent ligands

readouts: proximity, immuno assays, pulldowns Validated antibodies + digital search platform Entire library  (e.g., 14-3-3) Heterodimerization Endogenous vs. overexpressed systems Orphan GPCR deorphanization Ligand students and visiting scientists are already expanding this work, bringing in computational layers  like Listen to the complete episode to learn more. _________________ Keyword Cloud : GPCR scientist network

GPCRs in Disease Sakmar highlights how endothelial cells, which express a wide array of GPCRs, are likely The Tools to Detect Them Using the multiplexed GPCR library and Luminex assay , researchers can now: sees a future where this system is not just used for detection, but for functional screening : add ligands

This collaboration aims to amplify the visibility and adoption of Celtarys’ cutting-edge fluorescent ligand Celtarys Research develops high-quality, fluorescently labeled ligands and innovative chemical biology These tools enable high-resolution binding studies, kinetic analysis, and live-cell imaging, empowering “We’re thrilled to partner with Celtarys and introduce their high-performance fluorescent ligands to binding in live cells, and design better experiments, core to advancing GPCR-targeted discovery.”

trajectory in motion, culminating in a scalable, multiplexed platform to investigate GPCR-RAMP biology  like What emerged was a dual-tagged GPCR library  (DUET constructs), now publicly available via Addgene ,

arrestin engagement, a biased NTSR1 modulator targets pain without the need for opioids, and a real-time lipid Terry Kenakin, these five modules reveal how location bias, intracellular signaling, and ligand kinetics

Moments like these helped him own his identity as a scientist.

GPCR Store is live!   — A tale of detergent tails: GPCR activation beyond ligands .   A new commentary highlights how detergents and cholesterol shape mGluR2 activation—no ligand required

This week brings sharp new insights into how minor changes in ligand structure can flip GPCR function When someone signs up for a course, membership, or event through your referral link, you’ll receive a

Terry Kenakin, and catch up on cutting-edge insights through our full library of symposia recordings, Learn the fundamentals of ligand activity, mechanism of action, and GPCR discovery strategy—all at your Arrestin2 binds β₁AR without ligand-induced activation, reshaping our understanding of biased signaling A new cell-based tool detects receptor activity and reveals endogenous ligands.   Whether you're decoding a hidden receptor state or hunting for the next orphan GPCR ligand, we're here

It's starting to look a lot like Christmas at Dr. GPCR! Listen up, folks! VI drives arrestin-independent internalization and signaling of GPCRs Corticotropin-releasing factor-like learning GPCRs in Oncology and Immunology Short-chain fatty acids and cancer The path of GPR87: from a P2Y-like Insights into GPCR Function AlphaFold3 versus experimental structures: assessment of the accuracy in ligand-bound

’s Highlights: G protein-coupled receptor (GPCR) pharmacogenomics Miles D Thompson , David Reiner-Link Recorded GPCR Courses and Symposia / Summit 💲 Special Pricing on GPCR courses GPCR Forum Start a lively Direct line to the Dr. GPCR community members Join the GPCR fan club and geek out with fellows! It's like having a treasure map to academic success! receptors Structural insights into endogenous ligand selectivity and activation mechanisms of FFAR1

High-affinity agonists reveal recognition motifs for the MRGPRD GPCR Chunyu Wang ,  Yongfeng Liu ,  Marion 2025: adding odorant receptors, data mapper, structure similarity search and models of physiological ligand A bitter anti-inflammatory drug binds at two distinct sites of a human bitter taste GPCR Lior Peri ,   if you go for a Premium Membership , you'll not only back our mission but also snag fantastic perks like Direct line to the Dr.

It challenges you to push your limits, adapt to unforeseen challenges, and develop habits that will serve

angiotensin II-induced calcium signaling in striatal neurons Rafael Rivas-Santisteban , Ana Muñoz , Jaume Lillo community and delivering exceptional services to achieve our goal of leading a vibrant and healthy life Direct line to the Dr. We're working hard to keep the lights on and the coffee brewing by sprinkling a bit of magic on our revenue (MC4R-like) mutations in goldfish (Carassius auratus) Identification of a vital transcription factor

a collection of titratable residues spans from the extracellular surface to the transmembrane area, linking strategies, where drugs are designed to target multiple sites or pathways simultaneously, reducing the likelihood Limitations Deep mutational scanning encounters several constraints that affect its broad applicability DMS requires considerable resources, including time, financial investment, and specialised expertise, limiting Future directions As deep mutational scanning continues to evolve, its future directions will likely