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Results found for "Institute for Research in Immunology and Cancer"

  • Assay Volume Control: Your GPCR Drug Discovery Power Lever

    Enhance your GPCR research with deeper assay insights for more effective results. Plus: new research on CaSR, leptin signaling, and inflammation-linked GPCRs — and curated roles in computational Become a Premium Member today. ➤ 🎓 Full GPCR University + 🔬 200+ expert talks 🗞️ Weekly research, networking, AMAs & matchmaking 💡 Support open resources for the global GPCR field 🧠 Designed for researchers

  • Adhesion GPCR Consortium Newsletter - May 2024

    Investigación y de Estudios Avanzados del IPN (Cinvestav) How did you become involved in adhesion GPCR research What challenges will researchers overcome in the next 10 years? AB: The next workshop will likely bring together some of the hottest adhesion GPCR research going on New Insights Members Torsten Schöneberg and Ines Liebscher present an interactive browser-based application

  • 📰 GPCR Weekly News, February 20 to 26, 2023

    Small-molecule targeting of GPCR-independent non-canonical G protein signaling inhibits cancer progression Methods & Updates in GPCR Research GPCRLigNet: rapid screening for GPCR active ligands using machine Bioinformatics/Data Science at Department of Drug Design and Pharmacology Scientist/Senior Scientist (Research

  • Mapping Motion: Intermediate States, Deorphanization & Discovery

    GPCR Symposia and dive into big ideas from top scientists, early-career researchers, and innovators shaping Explore this week’s research, tools, and biotech insights in one place.

  • Community guidelines for GPCR ligand bias: IUPHAR review 32

    Ligands eliciting biased signalling may constitute better drugs with higher efficacy and fewer adverse The guidelines will aid consistency and clarity, as the basic receptor research and drug discovery communities

  • 📰 GPCR Weekly News

    Non-canonical Golgi-compartmentalized Gβγ signaling: mechanisms, functions, and therapeutic targets Constitutive impairs growth of patient-derived xenografts of colorectal carcinoma in mice Methods & Updates in GPCR Research Interactions in the Serotonin 1A Receptor Microenvironment Industry News Addex and Indivior Extend Research

  • How Advanced GPCR Kinetics Sharpen Decision Making (and Save You Time)

    Exploring the Hidden Dynamics: How Kinetics Reveals What Equilibrium Conceals in GPCR Research. members get to rewatch the recording Subscribe to the Kenakin Brief and Join the Live AMA ➤ Celtarys Research master GPCR science — in one membership. 🎓 Full GPCR University + 🔬 200+ expert talks 🗞️ Weekly research networking, AMAs & matchmaking 💡 Support open resources for the global GPCR field 🧠 Designed for researchers

  • Mechanism vs. Assumption: A Model-First Path to Getting GPCR MoA Right

    Fluorescent probes illuminate the mysteries of GPCRs in cutting-edge research. God Molecule"; Novo Nordisk looks to next generation of obesity, diabetes drugs with $550M Replicate research Career opportunities:  Research Assistant; Postdoctoral Associate; Senior Scientist, Data Science—curated Join Terry's Corner Today ➤ Celtarys Research – Confocal Imaging That Preserves GPCR Function Confocal

  • OMass Therapeutics's founder, Carol Robinson, has been awarded the prestigious Louis-Jeantet ...

    by the Louis-Jeantet Foundation and the 2022 Benjamin Franklin Medal in Chemistry from The Franklin Institute by the Louis-Jeantet Foundation and the 2022 Benjamin Franklin Medal in Chemistry from The Franklin Institute

  • Why Kinetics Matter More Than Kd in GPCR Drug Discovery

    ahead without noise or delays: Industry insights:  Structure-Based Drug Design Summit; AI-Powered GPCR Research unconventional path—from patient to scientist—exemplifies why personal mission matters in translational research Redefine your playbook:  Why Serafini believes that pain research needs to start from clinical phenotype s Corner  digital pharmacology courses Priority access to insights from major conferences, emerging research

  • Irreversible Drugs, Real Control: Design for Durable Target Engagement

    Membership Gives You: Proven frameworks used in real discovery programs On-demand lessons built for tight research Become a Premium Member today. ➤ 🎓 Full GPCR University + 🔬 200+ expert talks 🗞️ Weekly research, networking, AMAs & matchmaking 💡 Support open resources for the global GPCR field 🧠 Designed for researchers

  • Unlock the Hidden Complexity Behind GPCRs—From Terry Kenakin’s Vault

    Join Terry’s Corner and stay updated on the latest in GPCR research—delivered in a format that’s as approachable

  • Understanding Orthosteric Binding: The Key to Drug Action

    This foundational knowledge guides researchers in the development of new therapeutics. By considering factors like the Langmuir adsorption isotherm and binding curves, researchers can better

  • 📰 GPCR Weekly News, December 18 to 31, 2023

    Receptor-Lipid Microenvironment Basal interaction of the orphan receptor GPR101 with arrestins leads to constitutive mediated neuroprotective mechanism through autophagy-mediated NLRP3 degradation Methods & Updates in GPCR Research Principal Investigator, In Vitro Biology NEW Associate Scientist Postdoctoral Scholar - O’Neill Lab Junior Research Scientist Postdoctoral Fellow Post-Doc Research Associate Assistant/Associate Professor Explore Dr.

  • 📰 GPCR Weekly News, May 22 to 28, 2023

    intertwining roles of caveolin, oxytocin receptor, and the associated signalling pathways in prostate cancer November 2 - 4, 2023) GPCR Jobs NEW Associate Director / Director, Clinical Operations Postdoctoral Research

  • 📰 GPCR Weekly News, January 23 to 29, 2023

    Keep up-to-date with the latest research and advancements in the field with our convenient, weekly news Methods & Updates in GPCR Research Development and Characterization of a Highly Selective Turn-On Fluorescent GPCR Jobs Scientist/Senior Scientist (Research Software Engineer) Senior Scientist – Native Mass Spectrometry Biochemistry) Speculative Applications (Mass Spectrometry) Speculative Applications (Chemistry) Post-Doctoral Research Assistant Research Fellow - School of Physics and Astronomy Postdoctoral Research Associate (Fixed Term

  • 📰 GPCR Buzz: August 5-11, 2024 | Top Highlights from DrGPCR University!

    excitability of human induced pluripotent stem cell-derived nociceptive-like neurons Methods & Updates in GPCR Research Clinical Pharmacology GPCR Jobs Postdoc in GPCR mechanosensing   Postdoctoral Position Postdoctoral research position Senior or Lead Researcher   Senior Scientist, Cryo-Electron Microscopy   Postdoctoral Research

  • Dynamic GPCR activation revealed through time-resolved Cryo-EM

    complex with the β2-adrenergic receptor (β2AR) at brief sequential intervals following GTP addition, the research This research not only deepens our understanding of a key biological process but also provides a valuable map for pharmaceutical researchers to design new therapies.

  • 📰 GPCR Weekly News, February 13 to 19, 2023

    Get ready to stay up-to-date with the latest research, advancements, and news in the field. Bioinformatics/Data Science at Department of Drug Design and Pharmacology Scientist/Senior Scientist (Research Biochemistry) Speculative Applications (Mass Spectrometry) Speculative Applications (Chemistry) Post-Doctoral Research Assistant Research Fellow - School of Physics and Astronomy Postdoctoral Research Associate (Fixed Term

  • PH-Binding Motif in PAR4 Oncogene: From Molecular Mechanism to Drug Design

    October 2022 "While the role of G-protein-coupled receptors (GPCR) in cancer is acknowledged, their underlying demonstrate identification of a pleckstrin-homology (PH)-binding motif within PAR4, critical for colon cancer EGFR/erbB is among the most prominent cancer targets. Overall, our studies are expected to allocate new targets for cancer therapy. Pc(4-4) may become a promising candidate for future therapeutic cancer treatment."

  • Knowing When to Walk, Knowing When to Run: Lessons from the Bench

    Running Too Hard, Too Fast In research, there’s always more to do. Grants. Experiments.

  • Trevena Announces Advancement of TRV045 Into Clinical Development for Diabetic Neuropathic Pain

    In addition, through a collaboration with the National Institutes of Health, the Company is also exploring

  • Understanding Enzyme Inhibition In GPCR Discovery Programs

    He argues that early-career researchers often fall into the trap of over-rationalizing too soon—missing Become a Premium Member today. ➤ 🎓 Full GPCR University + 🔬 200+ expert talks 🗞️ Weekly research, networking, AMAs & matchmaking 💡 Support open resources for the global GPCR field 🧠 Designed for researchers

  • Discover the Hottest GPCR News of the Week: Oct 7-13, 2024!

    Congress of Basic and Clinical Pharmacology GPCR Jobs HIGHLIGHT Senior Scientist, GPCR Pharmacology Research co-transmission sets the activity pattern in the C. elegans egg-laying circuit Methods & Updates in GPCR Research biosensors Structural and Molecular Insights into GPCR Function Structural insights into KSHV-GPCR constitutive

  • Using Live-cell High-Content Screening to Characterize CB2 Ligands: Insights From 16 Synthetic Cannabinoids

    receptor type 2 (CB2R) has emerged as a compelling target across inflammation, immune modulation, and pain research By quantifying ligand–receptor interactions directly in intact cells, HCS allows researchers to observe Providing full tracer information ensures that researchers can recalculate or align affinity values across For researchers working in cannabinoid pharmacology, inflammation, or GPCR-mediated analgesia, these

  • How a Failed Experiment Created a Powerful GPCR Imaging Tool

    relied on: Antibodies of inconsistent specificity Fixed tissue sections Indirect signaling readouts Researchers conversation is part of a three episode series produced in collaboration with our partners at Celtarys Research

  • From GPCR Data Chaos to Decisive Action

    Here’s what I bring: Biology-First Strategy I’ve designed GPCR assays, led collaborations across research Firms  – Looking to accelerate, troubleshoot, or validate GPCR assets in their portfolio. ✅ Contract Research

  • Emerging approaches for decoding neuropeptide transmission

    November 2022 "Neuropeptides produce robust effects on behavior across species, and recent research has Current research has focused on isolating when and how neuropeptide transmission occurs, as well as the

  • GRK2 in cardiovascular disease and its potential as a therapeutic target

    advances in the field of pharmacological CVD treatments, particularly in the field of heart failure (HF) research Thus, identifying novel molecular targets for developing HF therapeutics remains a key research focus These data support the premise that GRK2 should be at the forefront of a novel investigative drug search functions of GRK2 in cardiac function and maladaptive pathology, and summarizes the ongoing and future research

  • Dynamics of tumor-associated macrophages in a quantitative systems pharmacology model of...

    macrophages in a quantitative systems pharmacology model of immunotherapy in triple-negative breast cancer It has begun to play important roles in drug development for complex diseases such as cancer, including triple-negative breast cancer (TNBC). incorporated the dynamics of TAMs into our previously published QSP model to investigate their impact on cancer

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