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Axon regeneration in response to injury is determined by the interaction between the extracellular environment

The cytoskeletal protein filamin A (FLNA) directly interacts with both somatostatin receptor type 2 ( Finally, immunofluorescence data showed that SST2 and SST5 recruitment at the plasma membrane and internalization On the contrary, in M2 cells, octreotide failed to internalize both receptors whereas pasireotide promoted robust receptor internalization at shorter times than in A7 cells.

Canonical chemokine receptors – scavenging “decoys” Chemokine receptors coordinate cell migration upon interaction Then β-Arrestin recruitment takes place allowing receptor internalization through clathrin-mediated pits , which is surprising since internalization is known to be a consequence of β-arrestin recruitment. In addition, constitutive internalization of CCR2 was shown to be G protein-independent by a “prelabel β-arrestin2, and constitutively internalizes in a β-arrestin2–dependent manner (C.

The interaction between these two receptor types raises intriguing questions about how their signaling

drug for the specific treatment of pSS. β-arrestin2 is a key protein that mediates desensitization and internalization downregulated GRP78-ATF6-CHOP apoptosis signaling to alleviate cell apoptosis, and the effect depended on the interaction

-17, 2023) ASCEPT Annual Scientific Meeting (November 20 -23, 2023) Structure, Mechanism, and Drug Interactions

bind to the receptor’s primary active site—can now be optimised by targeting specific ligand-receptor interactions

drug leads is aided by molecular docking simulations that allow critical analysis of the potential interactions

The reality is dynamic—ligands arrive, depart, and interact in ways that standard assays often miss.

Structure, Mechanism, and Drug Interactions of GPCRs, Ion Channels, and Transport Proteins (March 24

These dimeric interactions may contribute to the phenomenon of biased agonism, where ligands produce ) has revealed that GLP-1R homodimerization occurs via transmembrane helix 4 (TM4), which forms the interface Guo, W., et al., Crosstalk in G protein-coupled receptors: Changes at the transmembrane homodimer interface

inhibit Ca2+ entry, or directly at SNARE complexes to inhibit Ca2+-dependent synaptotagmin-SNARE complex interactions

Structural Understanding of Peptide-Bound G Protein-Coupled Receptors: Peptide-Target Interactions. SLAS2023 International Conference and Exhibition (February 25 - March 1, 2023). 2nd ERNEST Training School

ARRB1 interacted with HBx, and the autophagic core protein MAP1LC3/LC3, a scaffolding protein, was essential

with Alzheimer disease revealed by genomic analysis restricted to variants impacting gene function Interaction Congress of Basic and Clinical Pharmacology 2026 GPCR Jobs NEW Research Technologist I Senior Scientist- Internal

GPCRs in Neuroscience GPCR interactions involving metabotropic glutamate receptors and their relevance

progress on the role of orphan receptor GPR139 in neuropsychiatric behaviours Rhodopsin orphan GPCR20 interacts Meetings, and Webinars January 16 - 19, 2024 | 23rd Annual PEP Talk February 3 - 7, 2024 | SLAS2024 International

-17, 2023) ASCEPT Annual Scientific Meeting (November 20 -23, 2023) Structure, Mechanism, and Drug Interactions

, 2023) NEW ASCEPT Annual Scientific Meeting (November 20 -23, 2023) Structure, Mechanism, and Drug Interactions

protein-coupled receptors: A target for microbial metabolites and a mechanistic link to microbiome-immune-brain interactions Conference November 20 - 23, 2023 | ASCEPT Annual Scientific Meeting February 3 - 7, 2024 | SLAS2024 International

Report of the 4th international symposium. GPCRs in Oncology and Immunology GPR176 Promotes Cancer Progression by Interacting with G Protein GNAS

basis of μ-opioid receptor targeting by a nanobody antagonist Probing the energy landscape of the lipid interactions

and Signaling Unraveling the crosstalk between renin-angiotensin system receptors Arrestin-centred interactions Clinical Pharmacology 2026 GPCR Jobs NEW Postdoctoral Associate Research Technologist I Senior Scientist- Internal

-17, 2023) ASCEPT Annual Scientific Meeting (November 20 -23, 2023) Structure, Mechanism, and Drug Interactions

Internal and external modulation factors of the orexin system (REVIEW). Multi-omics integration analysis of GPCRs in pan-cancer to uncover inter-omics relationships and potential Structure, Mechanism, and Drug Interactions of GPCRs, Ion Channels, and Transport Proteins (March 24

Immunology Molecular docking and dynamics simulation studies uncover the host-pathogen protein-protein interactions February 1 | GPCR Forum ECI February 3 - 7, 2024 | SLAS2024 International Conference and Exhibition February

the human chemokine receptor CXCR2 indicates G protein bias over β-arrestin recruitment and receptor internalization Insights into GPCR Function Segregation of nascent GPCRs in the ER-to-Golgi transport by CCHCR1 via direct interaction Meetings, and Webinars January 16 - 19, 2024 | 23rd Annual PEP Talk February 3 - 7, 2024 | SLAS2024 International

GPCR Activation and Signaling GPCR-dependent and -independent arrestin signaling Direct GPCR-EGFR interaction

ArreSTick motif controls β-arrestin-binding stability and extends phosphorylation-dependent β-arrestin interactions

Scribble scrambles parathyroid hormone receptor interactions to regulate phosphate and vitamin D homeostasis