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This week's highlight includes congrats to: Junyi Liang, Niña Caculitan, and Adam W Smith for their research

Nicola Smith, Molecular Pharmacologist, lab head, and senior lecturer at UNSW Sydney.

Although major advances in predictive tools have reduced PK-driven attrition, misconceptions about ADME Too often, fundamentals are undervalued: in vitro assays are treated as routine checkboxes, and ADME In This Session, You’ll Gain Clarity on how ADME governs translational success A deeper understanding The Independence of Drug Attributes Primary activity, ADME, and safety form three independent axes of ADME as the Engine of Translation True PK mastery reveals its value at the point of translation.

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W.; Wu, Y.; Zhao, S.; Shui, W.; Li, S.; Korde, A.; Laprairie, R. B.; Stahl, E. L.; Ho, J. W.; Iyer, M. R.; Cinar, R.; Coffey, N. Chem.   2019 , 62  (1), 276–287. https://doi.org/10.1021/acs.jmedchem.8b00368 . (9)         Adams, A.       Martín-Fontecha, M.; Angelina, A.; Rückert, B.; Rueda-Zubiaurre, A.; Martín-Cruz, L.; Van De Veen, W. J.; Guba, W.; Alker, A.; Rufer, A. C.; Kusznir, E. A.; Huber, S.; Raposo, C.; Zirwes, E.

W.; Santi, D. V. Long-Term Stabilization of Maleimide–Thiol Conjugates. W. Cu-Catalyzed Azide−Alkyne Cycloaddition. Chem.

Shen S, Zhao C, Wu C, Sun S, Li Z, Yan W, et al. Crilly SE, Ko W, Weinberg ZY,Puthenveedu MA. Truong ME, Bilekova S, Choksi SP, Li W, Bugaj LJ, Xu K, et al. Franzen MM, Alder ML, Dreyer F, Köpp W, Buchholz MB. Wilner W. Participatory experience: the participant observer paradox.

W.; Högl, B.; Bainbridge, J.; Buchfuhrer, M.; Hadjigeorgiou, G.; Inoue, Y.; Manconi, M.; Oertel, W.; Ondo, W.; Winkelmann, J.; Allen, R. . https://doi.org/10.1016/j.tips.2017.10.004 . (9)         Marheineke, K.; Grünewald, S.; Christie, W. Dordrecht, 2014; pp 55–74. https://doi.org/10.1007/978-94-007-7423-0_4 . (12)      Yung-Chi, C.; Prusoff, W.

.; Li, W.; Florin, N. C.; Scheiff, A. B.; Müller, C. , 2009; Vol. 193, pp 1–24. https://doi.org/10.1007/978-3-540-89615-9_1 . (8) Yung-Chi, C.; Prusoff, W.

Terry W. Moore, was most definitely a success.

vesicle-associated-membrane-protein-2-is-a-cargo-selective-v-snare-for-a-subset-of-gpcrs #GPCR #DrGPCR#Ecosystem Crilly, S.E., W. Wickner, W., and R. Schekman. 2008. Membrane fusion. Nat. Struct. Mol. Biol. 15:658–664.

H., Pautsch, A., Steyaert, J., Weis, W. I., & Kobilka, B. K. (2011). C., Gmeiner, P., Steyaert, J., Weis, W. I., Garcia, K. C., Wess, J., & Kobilka, B. K. (2013).

Jang W, Senarath K, Feinberg G, Lu S, Lambert NA.

Nature 630, 493–500 (2024). https://doi.org/10.1038/s41586-024-07487-w

Adapted from: Zhang Y, Tang H, Chen W, Zhang J.

Earl W. Earl W. Earl W. Sir James W. Sir James W.

Stallaert, W., et al., Purinergic Receptor Transactivation by the β(2)-Adrenergic Receptor Increases

Guo, W., et al., Crosstalk in G protein-coupled receptors: Changes at the transmembrane homodimer interface

W., & Skiniotis, G. (2023).

G., Coyote-Maestas, W., & Aashish Manglik. (2024).

For example, OR4M1 was proposed to interfere with aberrant tau hyperphosphorylation (Zhao W. et. al 2013

. * In addition to the W-54011, the unmodified pharmacophore 1 was used as internal control for further

contributes to inflammatory joint pain Luke A Pattison , Rebecca H Rickman , Graham Ladds , Ewan St John Smith

Extracellular signal-regulated kinases – a potential pathway for GPCR-targeted drug discovery Nicola J Smith

their imbalance is linked to pathological conditions, including cancer (Gros, R. et al. 2000, Sun, W.

Nichola J Smith's investigation: Gene expression of TAS1R taste receptors for cardiometabolic disease

the engagement of the receptor with a certain effector, thus enriching a specific signaling pathway (Smith

previously established chemical space, limiting their ability to identify truly novel chemotypes”(Thomas, Smith