Search Results

.- Jan Steyaert, scientific director of the VIB-VUB Center for Structural Biology, Vlaams Instituut Biotechnologie Jan Steyaert will be presented with the Gabbay Award at Brandeis University on October 27 when he will

Lukas Grätz , Jan Voss , and Gunnar Schulte , for their study on Class-Wide Analysis of Frizzled-Dishevelled

I’m happy to share that I’m starting a new position as Scientific co-founder LASEREDD Therapeutics" Ross

October 2022 Dual loss of regulator of G protein signaling 2 and 5 exacerbates ventricular myocyte arrhythmias

October 2022 N-terminal alterations turn the gut hormone GLP-2 into an antagonist with gradual loss of

GPCRs posses a seven-transmembrane domain architecture, which lets them transduce extracellular signals Chem Rev. 2017 Jan 11;117(1):139-155. Chem Rev. 2017 Jan 11;117(1):139-155. doi: 10.1021/acs.chemrev.6b00177 Alavi MS, Shamsizadeh A, Azhdari-Zarmehri

Approval of TAVNEOS® (avacopan) for the Treatment of ANCA-Associated Vasculitis "SAN CARLOS, Calif., Jan

emerges with $100M to spark 'second golden age' of prolific drug target GPCR with pioneer as co-founder "Jan

and commercialization milestones, as well as a 10% royalty on net sales in China CHESTERBROOK, Pa., Jan

ACS Med Chem Lett. 2022 Jan 10;13(2):243-249. doi: 10.1021/acsmedchemlett.1c00598.

. 📝 Manuscript summary deadline: 23 Sept 2025 📄 Submission deadline: 11 Jan 2026 Submit to Volume II

Biochim Biophys Acta. 2014 Jan;1838(1 Pt A):15-33. doi: 10.1016/j.bbamem.2013.09.005.

Biochem Biophys Res Commun. 2023 Jan 15;640:64-72. doi: 10.1016/j.bbrc.2022.11.098.

for the understanding of the cochlea development, hearing disorders, and the treatment for hearing loss In addition, hearing loss can be caused by mutations of certain GPCRs, such as Vlgr1, Gpr156, S1P2, and A1, A2A, and CB2 activation by agonists has protective functions on noise- or drug-induced hearing loss GPCR in the cochlea and discuss the role of GPCR in the cochlea, such as stem cell fate, PCP, hearing loss

I was up every night thinking about how to hire, how to lead, how to avoid the mistakes my bad bosses

How do we prevent lean muscle loss during weight loss?

It’s about finding purpose through loss, choosing academia when many peers walk away, and designing science That personal loss transforms complex receptor pharmacology into something immediate and human.

Novo Nordisk’s amycretin showed up to 24% weight loss, CagriSema delivered 22.7% in Phase 3, and semaglutide

Mark:  “Beth, why would someone want you as their boss?”

dysregulated membrane trafficking, stability and phototransduction processes that lead to progressive loss

Moreover, independent of glucose control or weight loss, the anti-inflammatory actions of GLP-1RAs require

the so-called metabolic surgery whose beneficial effects are beyond dietary restrictions and weight loss

Independent secondary losses of the adipokinetic hormone/corazonin-related peptide receptor (ACP) and

damage to healthy cells in the process, leading to side effects that can include pain, nausea, and hair loss

cholesterol-depleted cells (using statins) by fluorescence recovery after photobleaching (FRAP) and fluorescence loss

pro-inflammatory properties in colonic macrophages through enhancing NLRP3 inflammasome activation, while the loss

Our results show that a mutation in the K101 residue leads to loss in thermal stability of the serotonin1A

Though most of these variants exhibit a loss of function, the molecular defects caused by these underlying

protein coupling bias of two AVPR2 mutants (R68W and V162A) that cause nephrogenic diabetes insipidus "Loss-of-function

efficacy depends on which cells express the receptor Side effects are tied to where agonists bind Weight-loss