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The biological validation came from Jean-Philippe Pin’s group at the Genomic Functional Institute in

layered collaborations—with Durham University chemist David Parker on the probe chemistry, and with Jean-Philippe Pin’s team in Montpellier to validate biological performance.

→ Discovery of pH-sensitive dual response (brightness + lifetime) → Application to GPCR models with Jean-Philippe Pin’s lab → Breakthrough internalization data in endogenous cells expressing GLP-1R → Commercial launch

Kawthar Belkacemi, Philippe Rondard, Jean-Philippe Pin, and Laurent Prézeau, for their research on Heterodimers

But Sokhom Pin stayed loyal to GPCRs , even when big pharma turned its gaze to other targets like kinases

At Alkermes , Sokhom Pin wasn’t just leading GPCR programs; he was building culture from the ground up

That’s exactly what Sokhom Pin did. Takeaway If you’re navigating work, life, and scientific ambition, Sokhom Pin proves it’s possible to

Juan Jose Fung, Principal Scientist, at GPCR Therapeutics.

January 2022 "OXFORD, England--Professor Charlotte Deane, Ph.D., of the University of Oxford, has joined Professor Deane joins Exscientia’s technology leadership team, reporting to Chief Technology Officer, Professor Deane is one of the UK’s most accomplished bioinformaticians. Prior to this, Professor Deane was Deputy Executive Chair of the Engineering and Physical Sciences Research Professor Deane holds a B.A. in Chemistry from the University of Oxford and a Ph.D. in Biochemistry from

.- Jan Steyaert, scientific director of the VIB-VUB Center for Structural Biology, Vlaams Instituut Biotechnologie Jan Steyaert will be presented with the Gabbay Award at Brandeis University on October 27 when he will

Pina Cardarelli, CSO of GPCR Therapeutics.

Sokhom Pin delivers brutally honest insights.  

Comps-Agrar L, Brock C, Rives ML, Bourrier E, Ayoub MA, Bazin H, Tinel N, Durroux T, Prézeau L, Trinquet E, Pin

But precision isn’t just about clean data; it’s about interpreting what that data means. At Alkermes, Sokhom Pin built an in vitro pharmacology group from scratch—not just a lab, but a culture

implications Structural and Molecular Insights into GPCR Function LYCHOS is a human hybrid of a plant-like PIN

Values represent the mean ± SEM of triplicate determinations. Data represent the mean ± SEM (n = 5 in triplicates). ( a ) concentration/response curves obtained for Values represent the mean ±SEM of triplicate determinations. Data represent the mean ± SEM (n = 5 in triplicates). ( a ) concentration/response curves obtained for A.; Bazin, H.; Tinel, N.; Durroux, T.; Prézeau, L.; Trinquet, E.; Pin, J.-P.

Where once a well-run assay was the pinnacle, now it’s the foundation — a starting point for more ambitious

approach to this problem by predicting potential resistance mutations before they are clinically observed (Pines BioRxiv (Cold Spring Harbor Laboratory) . https://doi.org/10.1101/2024.04.17.590000 Pines, G., Fankhauser

By pinpointing the molecular determinants of ligand efficacy and potency in GPCR signalling, this research

This week's highlight includes congrats to: Inês Pinheiro, for her Dr.

The way it is served with swiftly chopped charred pineapple for garnish adds to the visuals.

Inês Pinheiro and Oliver Hartley from the Orion Biotechnology team on their recent study on Arylsulfatases

Pinpointing signaling pathways governed by β-arrestins, which exhibit increased or reduced activity within

Devki D Sukhtankar and Pina M Cardarelli's research: Burixafor Hydrobromide (GPC-100) effects on hematopoietic

Expectations, EPS Lags “As Precision Medicine is critical, we cannot think about one size fits all” Dr Pina

Intermediate-state-trapped mutants pinpoint G protein-coupled receptor conformational allostery.

Industry News Josephine (Pina) Cardarelli from GPCR Therapeutics on Beyond Biotech Podcast Crinetics

Ping, Y.-Q., et al., Structural basis for the tethered peptide activation of adhesion GPCRs.

Additionally, we detect a shortening of PC in PINK1-deficient human cellular and mouse models of familial

Identification and functional characterization of the sulfakinin and sulfakinin receptor in the Chinese white pine However, there is no report on the functional role of SK in the Chinese white pine beetle, Dendroctonus