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Juan Jose Fung, Principal Scientist, at GPCR Therapeutics.

I’m happy to share that I’m starting a new position as Scientific co-founder LASEREDD Therapeutics" Ross

Self-docking and cross-docking simulations of G protein-coupled receptor-ligand complexes: Impact of of 11 Class A GPCR crystallized in multiple activation states (giving rise to 37 self-docking and 68 cross Our results show that one specific subset of cross-docking simulations gave results of similar quality RMSD values for top-scored poses were 1.2 Å and 2.0 Å for self-docking and StateMatch/FunctionMatch cross-docking

The gross proceeds to Crinetics from the offering, before deducting the underwriting discounts and commissions

Company agreed to sell 3,752,202 shares in the form of 625,367 American Depositary Shares (“ADSs”) at a gross

investor, to sell 3,300,000 shares in the form of 550,000 American Depositary Shares (“ADSs”) at a gross

It highlights its journey from one receptor to a cross-family toolkit. Hear from Drs.

The cross-talk between growth factor receptors and GPCRs is an intriguing area of study. consequences of specific phosphorylation events provide a deeper understanding of the molecular basis for cross-talk

physiological and pathological relevance of these interactions, since this additional level of molecular cross-talk

We collaborate and cross-pollenate a lot.”

these receptors were also detected, highlighting the robustness of the assay and the potential for cross-validation

Helen Su , et al. for their fantastic work on Germline mutations in a G protein identify signaling cross-talk research position GPCR Activation and Signaling Germline mutations in a G protein identify signaling cross-talk

Heterodimerization when Expressed Heterologously in Saccharomyces cerevisiae The beta 2 adrenergic receptor cross-linked

They often form homo- and heterodimers with allosteric cross-talk between receptor entities, which contributes

Rafael Rivas-Santisteban , Ana Muñoz , Jaume Lillo , Iu Raïch , Ana Rodríguez-Pérez , Gemma Navarro , José

Once a ligand crosses into this intracellular space, it behaves differently, often much more favorably

Heterodimerization when Expressed Heterologously in Saccharomyces cerevisiae The beta 2 adrenergic receptor cross-linked

operational details, such as misaligned data from diverse GPCR assay types or communication gaps in cross-functional

GPCR Industry News Septerna Announces the Formation of a Cross-Functional Scientific and Drug Discovery

With rigor, transparency, and cross-disciplinary collaboration, they’re pushing GPCR science toward a

He also underscores the value of developing cross-functional skills — including communication, strategy

stable, are believed to influence the function and regulation of GPCRs—a process known as receptor cross-talk

Early cross-screening can flag biased phenotypes long before animal studies.

This is especially useful in GPCRs, where structural similarity happens often and thus cross-reactivity

through binding to ADGRL1 and activating cAMP/PKA/CREB/BCL2 signaling pathway Deciphering specificity and cross-reactivity

Ines Liebscher, Ross Cheloha and Silvio Gutkind.

Further difficulties arise from the existence of cross-reactivity with other GPCRs and differences in

EC₅₀ and Emax uncouple affinity and efficacy, making cross-agonist comparison unreliable. Dr.

Canonical chemokine receptors as scavenging “decoys” Shivani Sachdev, Brendan Creemer, Thomas Gardella, and Ross

Nayara Braga Emidio, Ross Cheloha, Laura M Wingler, et al. for their work on Nanobody-Mediated Dualsteric