Search Results
Results found for "Madelyn Moore"
- VAMP2: a crucial player in the delivery of MOR to the synapse
VAMP2 can interact with other GPCRs, such as the beta-2 adrenergic receptor and the mu-opioid receptor (MOR this technology, they evidenced the presence of VAMP2, specifically in recycling vesicles containing MOR These data are fascinating because in the case of MOR, which is a receptor with several splicing variants modulated by different opioids, either endogenous or exogenous, promoving a differential organization of MOR Since MOR receptor regulates pain perception and reward, the dysfunction in the MOR-SNARE complex interaction
- New role of β-arrestins in MOR signaling
EOPs): β-endorphin, enkephalins and dynorphins, and four opioid receptors (ORs): μ-opioid receptor (MOR Morphine is an agonist of Mu opioid receptor (MOPR) and one of the objectives in the development of new Therefore to understand better the functions of arrestins in MOR signaling, Shiraki et al., explored the function of β-arrestin 2 in MOR signaling using the SH-SY5Y cell line that endogenously expresses MOR and was modified through CRISPR/Cas9 to knock out β-arrestin 1 and 2 gene expression.
- GRK3 is a poor prognosticator and serves as a therapeutic target in advanced gastric adenocarcinoma
Our genomic analysis showed that GRK3 expression correlated with poor prognosis of gastric adenocarcinoma
- GPCR Signaling and mTORC1 Regulation
The mammalian target of rapamycin (mTOR) senses upstream stimuli to regulate numerous cellular functions The activation of mTOR complex 1 (mTORC1) is typically observed in human disease and continues to be
- Hop in the Time Machine with GPCR: Unraveling the Future of Research! ⦿ Nov 24 - Dec 1, 2024
Johannes Broichhagen Design of allosteric modulators that change GPCR G protein subtype selectivity Madelyn N Moore , Kelsey L Person , Abigail Alwin , Campbell Krusemark , Ezequiel Marron Fernandez de Velasco receptors that regulate the release of superoxide anions SSTR2 positively associates with EGFR and predicts poor
- Maria’s Travel Blogs: ACSMEDI-EFMC Medicinal Chemistry Frontiers 2025
Moore, was most definitely a success.
- How GPCR Spatial Signaling Sparked a Scientific Journey
But luck only works if you say yes when the door opens. By understanding how signaling is organized in time and space, her team is opening doors to next-generation
- Job Opportunity Spotlight #1: Principal Scientist, In Vitro Pharmacology
I keep an open door and you’ll find me among the team in the lab quite often.
- Case Report of a Juvenile Patient with Autism Spectrum Disorder with a Novel Combination of Copy...
Clinical features included aggressive behavior, mood instability, suicidal statements, repetitive and
- Profiling Immune Cell and Platelet Transcriptomes
The ability to profile GPCR expression in a highly sensitive manner also opens doors for exploring the
- In vitro assays for the functional characterization of (psychedelic) substances at the serotonin...
the serotonin receptor 5-HT2A R "Serotonergic psychedelics are substances that induce alterations in mood
- From Pipettes to Platforms: The Evolution of GPCR Research
Technical mastery opened doors, but what kept her moving was knowing when to say yes before everything
- Molecular creativity in drug discovery
. • The Power of Structure : How privileged scaffolds and rational design open the door to dual activity
- Differential binding of Δ9-tetrahydrocannabinol derivatives to type 1 cannabinoid receptors (CB1)
They regulate mood, memory, appetite and motor function.
- From Farm Fields to GPCR Discovery, GLP-1 and GIP
Johannes Broichhagen - aka JB — which, amusingly, began when Hodson opened the door wearing cleaning
- Innovative Data-Driven Solutions: The pHSense Revolution
start wide with chemistry, you narrow with biology, and at the end—if you did it right—you open new doors
- How Breakthroughs Happen: Eric Trinquet on Innovation, Serendipity & GPCRs
That opened the door to something rare in functional pharmacology: plate-based GPCR internalization tracking
- GPCR Drug Discovery at Discovery on Target: Why This Track Is About More Than Receptors
Whether you’re in early discovery or clinical development, the strategies here could open doors in your
- How to Use Statistical Methods to Strengthen Every GPCR Drug Discovery Decision
tools tracking receptor motion; obesity drug strategies shifting; antibody pharmacology opening fresh doors
- The Truth About GPCR Product Launches: Years in the Making
That opened the door to a 2D sensor—one that responded cleanly to endosomal acidification with unmatched
- How a Failed Med School Dream Sparked a GPCR Biotech Revolution
But for Ajay Yekkirala, that closed door lit the fuse for a career that would reimagine GPCR therapeutics
- Understanding the Journey: Catherine Demery's Path to Addiction Science
Catherine's decision to defer pharmacy school was a leap of faith that opened new doors.
- How Collaboration Drives GPCR Discoveries
They start with a chance email, an unexpected visitor at the door, or the moment a team realizes the
- Targeting GPCRs in the CNS: Advances in Drug Discovery Strategies
Most of these are essential processes, such as neurotransmission, synaptic plasticity, mood, cognition , motor control and sensory perception. The activation of these pathways regulates pain modulation, memory consolidation, motor coordination Some of these are GPR6, GPR37 and GPR139 , which participate in motor control, neuroprotection and metabolic
- Why Kinetics Matter More Than Kd in GPCR Drug Discovery
modulators of the A1 adenosine receptor; GPR171 is necessary for normal physiological functions and mood-related
- GPCR Collaboration: From Models to Medicine
GPCRs regulate essential functions from vision to mood to cardiovascular control.
- Beyond Clearance: The Strategic Power of Irreversible Drug Binding
For discovery teams, this means a shorter exposure can yield longer efficacy windows—opening doors to
- Advantages of Fluorescent Probes in GPCR Assays
However, over half of non-sensory GPCRs do not have drugs available in the clinic, opening the door to
- How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology
That breakthrough launched the first wave of GLP-1R visualization studies and opened the door to deeper
- Orthosteric vs Allosteric Interactions— and the pHSense Shift in Internalization
That subtle distinction opened the door to a brand-new assay format.






















