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Peri ,  Donna Matzov ,  Dominic R Huxley ,   Peter Gmeiner ,  Peter J McCormick ,  Dorothee Weikert ,  Masha Y Niv ,  Moran Shalev-Benami , et al.

.; Horiuchi, Y.; Onaivi, E. S. W.; Wu, Y.; Zhao, S.; Shui, W.; Li, S.; Korde, A.; Laprairie, R. B.; Stahl, E. L.; Ho, J. -H.; Wu, Y.; Wu, L.; Popov, P.; Benchama, O.; Zvonok, N.; Locke, K.; Qu, L.; Han, G. W.; Iyer, M. V.; Mostinski, Y.; Mach, L.; Wasinska-Kalwa, M.; Weise, M.; Hoare, B. -N.; Vincent, S.; Guérineau, V.; Mély, Y.; Michel, B. Y.; Burger, A.

Ping, Y.-Q., et al., Structural basis for the tethered peptide activation of adhesion GPCRs. Qian, Y., Ma, Z., Liu, C., Li, X., Zhu, X., Wang, N., Xu, Z., Xia, R., Liang, J., Duan, Y., Yin, H., Xiong, Y., Zhang, A., Guo, C., Chen, Z., Huang, Z., & He, Y. (2022).

AlphaFold2 predicted water-soluble QTY variants and uncovering the natural mutations of L->Q, I->T, F->Y and Q->L, T->I and Y->F Industry News Sosei Heptares Doses First Subject in Phase 1 Trial with HTL0033744

detection, receptor activation initiates conformational changes, exposing an intracellular cavity (Kang, Y. high-resolution protein structures, illuminating side chain orientations and overall conformational states (Kang, Y. β-arrestins, paving the way for capturing challenging protein complexes (Böttke, T., et al. 2020, Aydin, Y. -Y. et al 2018).

Gurevich, et al. 2018; Y. A. Berchiche et al. 2011). The ability to rapidly recycle, which was shown by a chemokine washout BRET assay (Y. CCR2 inhibition leads to inhibition of scavenging and elevated plasma levels of CCL2 (Y.

Goswami, Y. Zhang, A.J.M. Molina, T.C. Südhof, and R.C. Malenka. 2013. Mozhayeva, Y. Sara, T.C. Südhof, and ¨ E.T. Kavalali. 2001.

Zhou, Y., et al., Multiple GPCR Functional Assays Based on Resonance Energy Transfer Sensors.  Namkung, Y., et al., Monitoring G protein-coupled receptor and β-arrestin trafficking in live cells using

tail-suspension and forced-swim tests, and comparable learning and memory abilities in the Morris water maze, Y

Zhuang, Y., et al., Structural insights into the human D1 and D2 dopamine receptor signaling complexes Hu, Y., et al., Identification of a five-gene signature of the RGS gene family with prognostic value

isolated from Cannabis   sativa , Scientifi c Reports (2020) 10(1):20405. doi: 10.1038/s41598-020-77175-y

Adapted from: Zhang Y, Tang H, Chen W, Zhang J.

and more Isolation and functional identification of secretin family G-protein coupled receptor from Y-organ

M., Pérez-Hernández, G., Batebi, H., Gao, Y., Eskici, G., Seven, A.

ligand binding, receptor activation, desensitization and trafficking is the apelin receptor (APJ) (Y.

Pharmacological inhibition of neuropeptide Y receptors Y1 and Y5 reduces hypoxic breast cancer migration

B y integrating them into GPCR workflows, discovery teams can accelerate identification, characterization

mutant-as-the-basis-for-personalized-high-throughput-drug-screening References Grimes, J., Koszegi, Z., Lanoiselée, Y.

Member Profile Antony Boucard Professor Centro de Investigación y de Estudios Avanzados del IPN (Cinvestav

.; Inoue, Y.; Manconi, M.; Oertel, W.; Ondo, W.; Winkelmann, J.; Allen, R. P. Structure-Based Design of High-Affinity Fluorescent Probes for the Neuropeptide Y Y1 Receptor. J.

Nature communications, 8(1), 443. https://doi.org/10.1038/s41467-017-00357-2 Jong, Y.

Alzheimers Dement (N Y). 2017;3(4):651-657. 11.         Dowden H, Munro J. Manchanda Y, ElEid L, Oqua AI, Ramchunder Z, Choi J, Shchepinova MM, et al.

fully integrated PROcisionXᵀᴹ discovery platform Structure-based validation of Orion’s approach Zheng, Y.