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January 2022 "After securing FDA approval for Wegovy last year, Novo Nordisk is strengthening its position

tracking biased signaling in Class B GPCRs, the membrane-driven modulation of mGluR2, and a big headline, Novo Nordisk’s $2.2B deal with Septerna to develop GPCR-targeted obesity therapeutics. 

Novo Nordisk’s amycretin showed up to 24% weight loss, CagriSema delivered 22.7% in Phase 3, and semaglutide

On the industry side, Novo Nordisk, Septerna, and Deep Apple advance billion-dollar GPCR programs, while

and Clinical Pharmacology 2026 GPCR Jobs Senior Associate Scientist - Global Research Technologies Novo Nordisk Scientist I - Global Research Technologies Novo Nordisk Postdoctoral Associate Research Technologist

Biochemistry Post Doctoral Fellow Postdoc Position Senior Associate Scientist - Global Research Technologies Novo Nordisk Scientist I - Global Research Technologies Novo Nordisk Join Dr.

Principal Scientist, In vitro pharmacology Senior Associate Scientist - Global Research Technologies Novo Nordisk Scientist I - Global Research Technologies Novo Nordisk Postdoctoral Associate Research Technologist

Principal Scientist, In vitro pharmacology Senior Associate Scientist - Global Research Technologies Novo Nordisk Scientist I - Global Research Technologies Novo Nordisk Postdoctoral Associate Research Technologist

Biochemistry Post Doctoral Fellow Postdoc Position Senior Associate Scientist - Global Research Technologies Novo Nordisk Scientist I - Global Research Technologies Novo Nordisk Join Dr.

Principal Scientist, In vitro pharmacology Senior Associate Scientist - Global Research Technologies Novo Nordisk Scientist I - Global Research Technologies Novo Nordisk Postdoctoral Associate Research Technologist

Announces $103 Million Series A Financing Co-Led by MPM BioImpact and Novo Holdings Neurocrine Biosciences Principal Scientist, In vitro Pharmacology Senior Associate Scientist - Global Research Technologies Novo Nordisk Scientist I - Global Research Technologies Novo Nordisk Postdoctoral Associate Research Technologist

Breakthroughs this week: Lilly to build $5B manufacturing facility in Virginia; Novo Nordisk flags drug

Submit a logo design by Nov 1st on the Logo Contest page. relatedness Industry News Nobel Laureates Highlight Symposium Celebrating Lefkowitz’s 50 Years at Duke Novo Nordisk stops Ozempic kidney trial after early signs of success Sosei and PharmEnable extend neurological

Immunotherapy Drug HTL0039732 Exscientia Business Update for Second Quarter and First Half of 2023 Novo Nordisk to acquire Inversago Pharma to develop new therapies for people living with obesity, diabetes

Subject in TRV045 Proof-of-Concept Trial Evaluating S1PR Mechanism of Action and Target Engagement Novo Nordisk's GLP-1 for Type II diabetes approved for first-line treatment The Lundbeck Foundation is awarding

Submit your logo design by Nov 1st on the Logo Contest page. Company in Immuno-Oncology, Domain Therapeutics, Presents Groundbreaking Advancements at ESMO 2023 Novo Nordisk to Buy Hypertension Treatment from KBP Biosciences Exscientia to Present New Preclinical Data

Breakthroughs this week:  5-MeO-DMT: the "God Molecule"; Novo Nordisk looks to next generation of obesity

Breakthroughs this week: Novo Nordisk cuts Ozempic® cost; Nxera launches obesity pipeline; Superluminal–Lilly

and Provides Business Update Crinetics Pharmaceuticals: Paltusotine Phase 3 Data Presented At ENDO Novo Nordisk to Acquire Inversago Pharma GPCR Events, Meetings, and Webinars NEW Antiverse: Reimagining Therapeutic

Channel Drug Developer Maxion Therapeutics Appoints Eva-Lotta Allan as Chair of its Board of Directors Novo Nordisk and Evotec collaborate to launch LAB eN², a translational drug discovery accelerator, to address

enable the identification of selective antagonists Industry News Inside the FDA's Form 483 findings at Novo Nordisk's North Carolina semaglutide plant Excellerate Bioscience Announces Site Relocation AI can help

News Duke University Celebrates Nobel Prize Winner Robert Lefkowitz’s 50 Years of Scientific Discovery Novo Nordisk Foundation Grants Fuel Exciting GPCR and Signaling Protein Research Tools First-In-Class Drug

Indeed, incretin-based drugs like Novo Nordisk's Wegovy and Eli Lilly's Zepbound are advancing diabetes

Health (RHU) SPRINT consortium grant to progress its proprietary CCR8 antibody candidate to the clinic Novo Radioligand Therapy Production Plant Novartis’ Lutathera reduces disease progression risk in GEP-NET trial Novo Nordisk hits $500 billion in market value as it flags soaring demand for Wegovy, Ozempic Dr.

Raised To Discover And Advance Novel Oral Small Molecule Medicines Targeting G Protein-Coupled Receptors Novo Nordisk A/S: Semaglutide 2.4 mg reduces the risk of major adverse cardiovascular events by 20% in adults

Research Collaboration with Amgen to Discover Small Molecule Therapeutics using Artificial Intelligence Novo Nordisk Invests 42 Billion Danish Kroner in New Manufacturing Facilities Addex ADX71149 Epilepsy Phase

drugmaker Septerna amasses $288M in IPO Surrounded by AI bio giants, tiny startup Nabla Bio makes de novo

Hey there, curious minds! Want to know what’s buzzing in the world of GPCRs? Join us for this week’s update, where you’ll find all the latest breakthroughs and exciting developments in GPCR research. We can’t wait to share it with you! This Week’s Highlights: Harnessing Deep Mutational Scanning for Enhanced Drug Discovery Cam Sinh Lu GPCR-BSD: a database of binding sites of human G-protein coupled receptors under diverse states Fan Liu , Han Zhou , Xiaonong Li , Liangliang Zhou , Chungong Yu , Haicang Zhang , Dongbo Bu 🤩 Seriously, why would you want to miss out on all the awesomeness that comes with a DrGPCR Premium Membership ? 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Classified GPCR News  Let’s dive into the   Classified GPCR News from November 4th to 10th, 2024 Industry News Lexaria Updates Fast-Moving GLP-1 'Arm's Race' Developments Five protein-design questions that still challenge AI Prix Galien USA: Domain Therapeutics Nominated for the Prestigious Best Startup Award Tectonic Therapeutic Announces Positive Phase 1a Results in AHA 2024 Presentation for TX45, a Long-acting, Fc-Relaxin Fusion Protein Nxera Pharma and Antiverse partner on GPCRs Nxera Pharma’s Partner Centessa Initiates Phase 2 Trial with ORX750, a Novel Orexin Receptor 2 (OX2R) Agonist AI, Synthetic Biology and Drug Discovery- with Aikium's Dr Venkatesh Mysore Trevena teeters in dangerous territory, terminating CEO and other execs amid strategic review Trevena Reports Third Quarter 2024 Results and Provides Business Update GPCR Events, Meetings, and Webinars NEW November 18 - 20, 2024 | 7th CB1 & CB2 Targeting Drug Development Summit November 25 - 26, 2024 | 6th International Conference on Stem Cell, Tissue Engineering and Regenerat November 25 - 27, 2024 | 1st Virtual GPCR Forum Conference November 26 - 28, 2024 | GPCRs-Targeted Drug Discovery Summit Europe December 10 - 12, 2024 | Pharmacology 2024 January 13 - 16, 2025 | PepTalk 2025 January 25 - 29, 2025 | SLAS 2025 February 15 - 16, 2025 | Structural and Functional Approaches in GPCR Drug Discovery February 15 - 19, 2025 | BPS 2025 February 16 - 21, 2025 | Harnessing the Power of Advanced Multimodal Approaches to GPCR Drug Discovery March 12 - 14, 2025 | NextGen Biomed 2025 March 25 - 28, 2025 | 10th German Pharm-Tox Summit April 1 - 5, 2025 | XXIII GEM Meeting in 2025 April 3 - 6, 2025 | ASPET 2025 April 14 - 17, 2025 | 20th Drug Discovery Chemistry April 24 - 27, 2025 | American Physiology Summit 2025 April 25 - 30, 2025 | AACR Annual Meeting 2025 May 12 - 15, 2025 | PEGS 2025 May 20 - 22, 2025 | SLAS Europe 2025 June 16 - 19, 2025 | BIO International Convention 2025 July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology GPCR Jobs Scientist I Cell Biology - Tectonic Therapeutic NEW Senior Principal Scientist, Medicinal Chemistry PhD fellowship in GPCR mechanosensing Senior Scientist, GPCR Pharmacology Research Associate - Professor Graeme Milligan Postdoc in Molecular Pharmacology - The Hauser Group Postdoctoral Scholar – iPSC in cardiac and endothelial cell function Protein Biochemist/Structural Biologist Senior Scientist/Staff Scientist, Computational Chemistry GPCR Activation and Signaling Pathophysiological significance and modulation of the transient receptor potential canonical 3 ion channel Smad transcription factors as mediators of 7 transmembrane G protein-coupled receptor signalling The voltage sensitivity of G-protein coupled receptors: Unraveling molecular mechanisms and physiological implications Sphingosine-1-phosphate activates LRRC8 volume-regulated anion channels through Gβγ signalling GPCR Binders, Drugs, and more PGE2 Binding Affinity of Hemocyte Membrane Preparations of Manduca sexta and Identification of the Receptor-Associated G Proteins in Two Lepidopteran Species GPCRs in Neuroscience Role of the GRK2/3 N-terminus in discriminating the endocytic effects of opioid agonist drugs GPCRs in Oncology and Immunology GPR56: GPCR as a guardian against ferroptosis Methods & Updates in GPCR Research Memprot.GPCR-ModSim: Modelling and simulation of membrane proteins in a nutshell Ciliary length variations impact cilia-mediated signaling and biological responses Structural and Molecular Insights into GPCR Function GPCR-BSD: a database of binding sites of human G-protein coupled receptors under diverse states Become a Premium Member! 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Grab your flux capacitors, GPCR time travelers! We're zooming back to the future of GPCR discoveries. Buckle up as we time-hop through this week's GPCR escapade! 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Our Ecosystem provides an impressive array of platforms tailored for GPCR students and professionals in industry and academia, offering unparalleled connections and opportunities. To fully explore our Ecosystem, scroll to the footer and check out our Map! To truly maximize your experience, you MUST get our Premium Membership and begin taking advantage of our exceptional features: Dr. GPCR University 🎥 Recorded GPCR Courses and Symposia / Summit 💲 Special Pricing on GPCR courses GPCR Forum Start a lively chat or request help with your research! GPCR Events Mark your glittery calendar with dates in 2025 ! GPCR Jobs Seeking a job or the perfect employee? Book a date with our Chief Match Maker! Direct line to the Dr. GPCR community members Join the GPCR fan club and geek out with fellows! So much more to come! 🕵️‍♂️ Get ready to crack the code, folks! We're about to reveal our University CheatSheet —a sneaky peek at all our talks, presentations, and courses. It's like having a treasure map to academic success! Please don't say we didn't give you a heads-up! Starting in 2025, only Premium Members can access Classified GPCR News. This change is all about keeping our community strong and delivering top-notch content. It'll help us keep things running smoothly and grow our community. Thanks for understanding and supporting us! Classified GPCR News  Let’s dive into the   Classified GPCR News from November 25th to December 1st, 2024 Industry News Amgen says obesity drug caused up to 20% weight loss after a year, with no plateau INAUGURATION OF AELIS FARMA NEW LABORATORY at Institut Européen de Chimie et Biologie (IECB) in Pessac (Bordeaux) AI-Powered Drug Discovery and Antibody Innovation: DeciBio Q&A with Sean McClain, Founder & CEO, and Zach Jonasson, CFO & CBO at Absci Octant: A Next Generation Approach to Genetic Disease Antiverse, Nxera Pharma Teams to Unleash Machine Learning on Elusive Biological Keys to Medical Therapies From Structure to Solution: How Structural Biology Informs the Development of Drugs Targeting G Protein-Coupled Receptors ARTICA THERAPEUTICS ANNOUNCES ESTABLISHMENT OF SCIENTIFIC ADVISORY BOARD GPCR Events, Meetings, and Webinars December 10 - 12, 2024 | Pharmacology 2024 January 13 - 16, 2025 | PepTalk 2025 January 25 - 29, 2025 | SLAS 2025 February 15 - 16, 2025 | Structural and Functional Approaches in GPCR Drug Discovery February 15 - 19, 2025 | BPS 2025 February 16 - 21, 2025 | Harnessing the Power of Advanced Multimodal Approaches to GPCR Drug Discovery March 12 - 14, 2025 | NextGen Biomed 2025 March 25 - 28, 2025 | 10th German Pharm-Tox Summit April 1 - 5, 2025 | XXIII GEM Meeting in 2025 April 3 - 6, 2025 | ASPET 2025 April 14 - 17, 2025 | 20th Drug Discovery Chemistry April 24 - 27, 2025 | American Physiology Summit 2025 April 25 - 30, 2025 | AACR Annual Meeting 2025 May 12 - 15, 2025 | PEGS 2025 May 20 - 22, 2025 | SLAS Europe 2025 June 16 - 19, 2025 | BIO International Convention 2025 July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology GPCR Jobs NEW GPCR Molecular Pharmacologist Scientist - Biology Scientist I Cell Biology - Tectonic Therapeutic Senior Principal Scientist, Medicinal Chemistry PhD fellowship in GPCR mechanosensing Senior Scientist, GPCR Pharmacology Research Associate - Professor Graeme Milligan Postdoc in Molecular Pharmacology - The Hauser Group Postdoctoral Scholar – iPSC in cardiac and endothelial cell function Protein Biochemist/Structural Biologist GPCR Activation and Signaling Exploring Bias in GPCR Signaling and its Implication in Drug Development: A One-Sided Affair Agonist activation to open the Gα subunit of the GPCR-G protein precoupled complex defines functional agonist activation of TAS2R5 Biased activation of the vasopressin V2 receptor probed by molecular dynamics simulations, NMR and pharmacological studies High-affinity ELR+ chemokine ligands show G protein bias over β-arrestin recruitment and receptor internalization in CXCR1 signalling GPCR Binders, Drugs, and more G protein-coupled receptor (GPCR) pharmacogenomics Antibodies expand the scope of angiotensin receptor pharmacology Chimeric antigens displaying GPR65 extracellular loops on a soluble scaffold enabled the discovery of antibodies, which recognized native receptor Design of allosteric modulators that change GPCR G protein subtype selectivity GPCRs in Cardiology, Endocrinology, and Taste Integrated bioinformatics analysis reveals that CCBP2 and GPR87 are new GPCR-associated biomarkers for preeclampsia Metabolic control of Luteinizing Hormone-responsive ovarian steroidogenesis Cardiovascular Complications and Their Association With Short- and Long-Term Outcomes in Patients With Multiple Myeloma and Lymphoma Undergoing Chimeric Antigen Receptor T-Cell Therapy GPCRs in Neuroscience Innervation density governs crosstalk of GPCR-based norepinephrine and dopamine sensors Intranasal delivery of liposome encapsulated flavonoids ameliorates l-DOPA induced dyskinesia in hemiparkinsonian mice GPR88 impairs the signaling of kappa opioid receptors in a heterologous system and in primary striatal neurons GPCRs in Oncology and Immunology Protease-Activated Receptor-1 IgG Autoantibodies in Patients with COVID-19 Signaling by neutrophil G protein-coupled receptors that regulate the release of superoxide anions SSTR2 positively associates with EGFR and predicts poor prognosis in nasopharyngeal carcinoma RNAi library screening reveals Gβ1, Casein Kinase 2 and ICAP-1 as novel regulators of LFA-1-mediated T cell polarity and migration Methods & Updates in GPCR Research Calcineurin-fusion facilitates cryo-EM structure determination of a Family A GPCR Red and far-red cleavable fluorescent dyes for self-labelling enzyme protein tagging and interrogation of GPCR co-internalization AlloViz: A tool for the calculation and visualisation of protein allosteric communication networks GPTrans: A Biological Language Model-Based Approach for Predicting Disease-Associated Mutations in G Protein-Coupled Receptors Structural and Molecular Insights into GPCR Function Inhibitory effect of truncated isoforms on GPCR dimerization predicted by combinatorial computational strategy Uncovering conserved networks and global conformational changes in G protein-coupled receptor kinases The membrane domains of mammalian adenylyl cyclases are lipid receptors Structural insights into endogenous ligand selectivity and activation mechanisms of FFAR1 and FFAR2 Become a Premium Member! 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Hoist the sails, GPCR sailors! The GPCR ship is setting sail on a grand voyage across the vast ocean of research. Dive in and explore the depths in this week's GPCR update! This Week’s Highlights: SNX9 family mediates βarrestin-independent GPCR endocytosis Valeria Robleto , Ya Zhuo , Joseph Crecelius , Sara Benzow , Adriano Marchese Cannabinoid regulation of angiotensin II-induced calcium signaling in striatal neurons Rafael Rivas-Santisteban , Ana Muñoz , Jaume Lillo , Iu Raïch , Ana Rodríguez-Pérez , Gemma Navarro , José Labandeira-García , Rafael Franco Endomembrane GPCR signaling: 15 years on, the quest continues Davide Calebiro , Tamara Miljus , Shannon O'Brien Advances in the molecular understanding of GPCR-arrestin complexes Ivana Petrovic , Stephan Grzesiek , Polina Isaikina NMR spectroscopy reveals insights into mechanisms of GPCR signaling Larissa Silva , Anuradha Wijesekara , Matthew Eddy At Dr. GPCR, the journey is just beginning! 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Classified GPCR News  Let’s dive into the   Classified GPCR News from November 11th to 17th, 2024 Industry News Centessa Launches Phase 2 Trial of ORX750 for Narcolepsy and IH Crinetics Pharmaceuticals Reports Third Quarter 2024 Financial Results and Provides Business Update Aelis Farma announces the positive results of its clinical Phase 1/2 Study with AEF0217 in young adults with Down syndrome Novartis pays Schrödinger $150M, bets billions on the back end to form drug discovery pact Aequorin: superior choice for GPCR calcium signalling GPCR: Structural Insights and Role in Drug Discovery Orion Biotechnology has a new website GPCR Events, Meetings, and Webinars November 25 - 26, 2024 | 6th International Conference on Stem Cell, Tissue Engineering and Regenerat ion November 25 - 27, 2024 | 1st Virtual GPCR Forum Conference November 26 - 28, 2024 | GPCRs-Targeted Drug Discovery Summit Europe December 10 - 12, 2024 | Pharmacology 2024 January 13 - 16, 2025 | PepTalk 2025 January 25 - 29, 2025 | SLAS 2025 February 15 - 16, 2025 | Structural and Functional Approaches in GPCR Drug Discovery February 15 - 19, 2025 | BPS 2025 February 16 - 21, 2025 | Harnessing the Power of Advanced Multimodal Approaches to GPCR Drug Discovery March 12 - 14, 2025 | NextGen Biomed 2025 March 25 - 28, 2025 | 10th German Pharm-Tox Summit April 1 - 5, 2025 | XXIII GEM Meeting in 2025 April 3 - 6, 2025 | ASPET 2025 April 14 - 17, 2025 | 20th Drug Discovery Chemistry April 24 - 27, 2025 | American Physiology Summit 2025 April 25 - 30, 2025 | AACR Annual Meeting 2025 May 12 - 15, 2025 | PEGS 2025 May 20 - 22, 2025 | SLAS Europe 2025 June 16 - 19, 2025 | BIO International Convention 2025 July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology GPCR Jobs Scientist I Cell Biology - Tectonic Therapeutic Senior Principal Scientist, Medicinal Chemistry PhD fellowship in GPCR mechanosensing Senior Scientist, GPCR Pharmacology Research Associate - Professor Graeme Milligan Postdoc in Molecular Pharmacology - The Hauser Group Postdoctoral Scholar – iPSC in cardiac and endothelial cell function Protein Biochemist/Structural Biologist Senior Scientist/Staff Scientist, Computational Chemistry GPCR Activation and Signaling SNX9 family mediates βarrestin-independent GPCR endocytosis A non-canonical mechanism of GPCR activation cGMP-dependent pathway and a GPCR kinase are required for photoresponse in the nematode Pristionchus pacificus Visualization of endogenous G proteins on endosomes and other organelles Mechanical stress and anionic lipids synergistically stabilize an atypical structure of the angiotensin II type 1 receptor (AT1) Identification and functional analysis of six melanocortin-4-receptor-like (MC4R-like) mutations in goldfish (Carassius auratus) Identification of a vital transcription factor of the alanine aminotransferase in the brown planthopper and its upstream regulatory pathways Divergent roles of DRY and NPxxY motifs in selective activation of downstream signalling by the apelin receptor GPR68 supports AML cells through the calcium/calcineurin pro-survival pathway and confers chemoresistance by mediating glucose metabolic symbiosis GPCR Binders, Drugs, and more Kinetic Basis for the Design of Azobenzene-Based Photoswitchable A2a Adenosine Receptor Ligands GPCRs in Cardiology, Endocrinology, and Taste Mechanistic Insights Into Redox Damage of the Podocyte in Hypertension Endurance exercise attenuates Gαq-RNAi induced hereditary obesity and skeletal muscle dysfunction via improving skeletal muscle Srl/MRCC-I pathway in Drosophila Chemogenetic activation of hepatic G12 signaling ameliorates hepatic steatosis and obesity GPCRs in Neuroscience GNG5 is a novel regulator of Aβ42 production in Alzheimer's disease Cannabinoid regulation of angiotensin II-induced calcium signaling in striatal neurons Receptor-dependent influence of R7 RGS proteins on neuronal GIRK channel signaling dynamics GPCRs in Oncology and Immunology Gallein, G protein βγ subunits inhibitor, suppresses the TGF-α-induced migration of hepatocellular carcinoma cells via inhibition of the c-Jun N-terminal kinase Methods & Updates in GPCR Research Conserved pattern-based classification of human odorant receptor multigene family Reviews, GPCRs, and more Endomembrane GPCR signaling: 15 years on, the quest continues Bound by the love for cholesterol: A transporter meets a GPCR Advances in the molecular understanding of GPCR-arrestin complexes Cholesterol sensing goes vegetarian Structural and Molecular Insights into GPCR Function NMR spectroscopy reveals insights into mechanisms of GPCR signaling Structural plasticity of arrestin-G protein coupled receptor complexes as a molecular determinant of signaling Become a Premium Member! 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