Samuel Hoare / Pharmechanics. Get your ticket now!

Samuel Hoare on Advanced data analysis for GPCR pharmacology, which will be held on Thursdays between The workshop includes: Four x 2-hour Zoom sessions One-on-one meeting with Dr. Hoare Access to Dr. Hoare's workshop for individuals who live and work in developing countries.

Hoare's workshop for individuals who live and work in developing countries.  Samuel Hoare on Advanced data analysis for GPCR pharmacology, which will be held on Thursdays between The workshop includes: Four x 2-hour Zoom sessions One-on-one meeting with Dr. Hoare Access to Dr. Sam Hoare about this hands-on workshop HERE ⬇⬇⬇ Dr.

Hoare's workshop for individuals who live and work in developing countries.  Samuel Hoare on Advanced data analysis for GPCR pharmacology, which will be held on Thursdays between The workshop includes: Four x 2-hour Zoom sessions One-on-one meeting with Dr. Hoare Access to Dr.

Samuel Hoare on Advanced data analysis for GPCR pharmacology, which will be held on Thursdays between The workshop includes: Four x 2-hour Zoom sessions One-on-one meeting with Dr. Hoare Access to Dr. Hoare's workshop for individuals who live and work in developing countries. Sam Hoare about this hands-on workshop HERE ⬇⬇⬇ Dr.

Samuel Hoare on Advanced data analysis for GPCR pharmacology, which will be held on Thursdays between Hoare, according to his availability Access to the cohort’s Dr. Hoare and your classmates Access to the course materials and recordings once the course is completed Hoare and Dr. GPCR Complementary one-year Dr. Hoare's workshop for individuals who live and work in developing countries.

The research of GPCRs in the cochlea is essential for the understanding of the cochlea development, hearing disorders, and the treatment for hearing loss. In addition, hearing loss can be caused by mutations of certain GPCRs, such as Vlgr1, Gpr156, S1P2, and And A1, A2A, and CB2 activation by agonists has protective functions on noise- or drug-induced hearing loss, and hearing protection."

September 2022 "G-protein-coupled receptors (GPCRs) are involved in a wide array of physiological and disease functions, yet knowledge of their role in colon cancer stem cell maintenance is still lacking. In addition, the molecular mechanisms underlying GPCR-induced post-translational signaling regulation are poorly understood. Here, we find that protease-activated receptor 4 (PAR4) unexpectedly acts as a potent oncogene, inducing β-catenin stability and transcriptional activity. Both PAR4 and PAR2 are able to drive the association of methyltransferase EZH2 with β-catenin, culminating in β-catenin methylation. This methylation on a lysine residue at the N-terminal portion of β-catenin suppresses the ubiquitination of β-catenin, thereby promoting PAR-induced β-catenin stability and transcriptional activity. Indeed, EZH2 is found to be directly correlated with high PAR4-driven tumors, and is abundantly expressed in large tumors, whereas very little to almost none is expressed in small tumors. A truncated form of β-catenin, ∆N133β-catenin, devoid of lysine, as well as serine/threonine residues, exhibits low levels of β-catenin and a markedly reduced transcriptional activity following PAR4 activation, in contrast to wt β-catenin. Our study demonstrates the importance of β-catenin lysine methylation in terms of its sustained expression and function. Taken together, we reveal that PAR-induced post-transcriptional regulation of β-catenin is centrally involved in colon cancer." Read more at the source #DrGPCR #GPCR #IndustryNews

Sam Hoare as our instructor. Gain invaluable skills in data analysis under Dr. Hoare's expert guidance. More details are coming soon—stay tuned! Dr.

Sam Hoare as our instructor. Under Dr. Hoare's expert guidance, you will gain invaluable skills in data analysis.

Sam Hoare as our instructor. With Dr. Hoare, you’ll learn how to analyze your data like a pro.

Come join us from October 10 to 16 to hear about exciting #GPCR research from amazing speakers.

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Excited to hear Dr.

Excited to hear Dr.

Only 4 hours per month are required. disease progression risk in GEP-NET trial Novo Nordisk hits $500 billion in market value as it flags soaring

Hear the story from our colleagues in this video."

Hear the story from our colleagues in this video."

Give it a listen to hear from Dr. Thomas P.

Join us for another virtual cafe talk to hear about the amazing work that Dr.

Crinetics recently reported that administration of CRN04894 reduced both serum cortisol levels and 24-hour

Join us for the first virtual cafe talk to hear about the amazing work that Dr.

network with GPCR scientists at our events, and get a complimentary Premium Membership with only 4 hours

The cost is $299 and includes: All 4 live Zoom sessions ( 4x 1 hour lecture + 30 mins Q&A) 30-minute

The cost is $299 and includes: All 4 live Zoom sessions ( 4x 1 hour lecture + 30 mins Q&A) 30-minute

network with GPCR scientists at our events, and get a complimentary Premium Membership with only 4 hours

The cost is USD $299 and includes: Four live Zoom sessions (1 hour lecture + 30 mins Q&A each) A 30-minute

The cost is $299 and includes: All 4 live Zoom sessions ( 4x 1 hour lecture + 30 mins Q&A) Complimentary