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GPCR on the 24th of June! This time, the GPCRdb team ( Dr. David Gloriam , Dr. Reserve your spot for free at: https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe/ #GPCR #GPCRs #DrGPCR

Previously, we identified potent positive crosstalk between insulin/IGF-1 receptors and G protein-coupled (GPCR Here, we show that a combination of insulin and the GPCR agonist neurotensin induced rapid activation Read more at the source #DrGPCR #GPCR #IndustryNews

October 2022 "Visual phototransduction is the most extensively studied G protein-coupled receptor (GPCR Read more at the source #DrGPCR #GPCR #IndustryNews

August 2022 "Background: Activation of signaling effectors by G-protein coupled receptors (GPCRs) depends participate in a molecular mechanism to trigger β-arrestin recruitment. " Read more at the source #DrGPCR #GPCR

GPCR Virtual Cafe session with Dr. Matthew E. on Friday, October 7th at 1 PM ET. Don't miss the chance to listen to his latest research on the field.

September 2022 "Metabotropic γ-aminobutyric acid receptor (GABABR), a class C G protein-coupled receptor (GPCR However, little is known about the mechanism for GP coupling and activation for class C GPCRs. This mechanism provides fresh insights into the mechanistic details of class C GPCRs activation expected Read more at the source #DrGPCR #GPCR #IndustryNews

October 2022 "Alzheimer's disease (AD) is the most common dementia in the elderly and its increasing Emerging evidence suggests adenosine G protein-coupled receptors (GPCRs) are promising therapeutic targets Read more at the source #DrGPCR #GPCR #IndustryNews

Hello GPCR Community, Stay up-to-date with the latest GPCR research, including breakthrough studies, top researchers to explore the latest advances in designing precise GPCR-targeted drugs, including the Research Services Agreement with Pfizer on Targeted Protein Degradation Modalities A quick revision July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology GPCR Jobs HIGHLIGHT Research mechanosensing   Postdoctoral Position Postdoctoral research position Senior or Lead Researcher   GPCR

August 2022 "G-protein-coupled receptors (GPCRs) receive signals from ligands with different efficacies Previous studies revealed how ligands with different efficacies activate GPCRs. Here, we investigate how a GPCR activates G-proteins upon binding ligands with different efficacies. These data provide insights into the ligand efficacy in the activation of GPCRs and G-proteins." Read more at the source #DrGPCR #GPCR #IndustryNews

August 2022 "Alzheimer's disease (AD) is the most common dementia in the elderly and its increasing prevalence Emerging evidence suggests adenosine G protein-coupled receptors (GPCRs) are promising therapeutic targets Read more at the source #DrGPCR #GPCR #IndustryNews

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Transporting Protein-coupled receptors (GPCRs) to the synapse, where they are involved in neurotransmission From a general overview, after GPCRs synthesis in the endoplasmic reticulum, GPCRs are transported to In the context of GPCR recycling, this process is complex and highly regulated that involves multiple However, the selectivity of SNARE complex proteins to regulate the release of different types of GPCRs /vesicle-associated-membrane-protein-2-is-a-cargo-selective-v-snare-for-a-subset-of-gpcrs #GPCR #DrGPCR

hypercalcemia caused by biased allosteric CaSR autoantibodies "Biased agonism is a frontier field in GPCR research. Our observations with these prominent commonalities may provide new insights into the phenotype and characteristics of AHH and the mechanisms by which the biased agonism of GPCRs operate." Read more at the source #DrGPCR #GPCR #IndustryNews

In addition, as an intermediary of G protein-coupled receptor (GPCR) signaling, the functions of ROCK Read more at the source #DrGPCR #GPCR #IndustryNews

Although some G-protein coupled receptors (GPCRs) were reported to play roles in osteoblast function, GPR110 belongs to adhesion GPCR and was the functional receptor of N-docosahexaenoyl ethanolamine (also Read more at the source #DrGPCR #GPCR #IndustryNews

Dear GPCR Community, Before diving into this week's news, prepare for an incredible learning journey! This week's highlight includes congrats to: Madison Walker , Benjamin Myers , et al., for their research Research Probing PAC1 receptor activation across species with an engineered sensor A Multi-Angle Approach Jobs Postdoc in GPCR mechanosensing   Postdoctoral Position Postdoctoral research position Senior or Lead Researcher   Senior Scientist, Cryo-Electron Microscopy   Postdoctoral Research Associate Become

GPCR News.   Elevate your pharmacology expertise. Unlock "Pharmacologic Models" now

August 2022 "Psychedelic research across different disciplines and biological levels is growing at a Read more at the source #DrGPCR #GPCR #IndustryNews

Searching for antagonist activity, we performed systematic N-terminal truncations of human GLP-2(1-33 Read more at the source #DrGPCR #GPCR #IndustryNews

GPCR Ecosystem is under construction and dozens of your colleagues are enjoying its benefits! Catch up with the latest #GPCR news, start a discussion in the forum, and much more today! Join the #GPCR movement by becoming a site member for FREE! ➡️ https://www.ecosystem.drgpcr.com/ #gpcr #drgpcr

October 2022 "Recently determined structures of class C G protein-coupled receptors (GPCRs) revealed treatment of psychiatric and neurodegenerative diseases, and several allosteric modulators of this GPCR libraries have complementary advantages and illustrate how access to high-resolution structures of GPCRs Read more at the source #DrGPCR #GPCR #IndustryNews

March 2022 ERNEST has established an Emergency Fund for Ukrainian researchers. "General Eligibility Researchers affiliated to any legal entity in Ukraine (for example, schools and universities, research centers, governmental institutions, or private companies) Deadlines Start of the Our scientific perspective is broad, and we are happy to consider any research proposals from those in Read more at the source #DrGPCR #GPCR #IndustryNews

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October 2022 "The canonical model for G protein-coupled receptors (GPCRs) activation assumes that stimulation In this model, GPCR signaling is turned-off by receptor phosphorylation via GPCR kinases (GRKs) and subsequent However, over the last decade, this model has been extended by discovering that some internalized GPCRs Accumulative evidence shows that the location of signaling has an impact on the physiological effects of GPCR Read more at the source #DrGPCR #GPCR #IndustryNews

August 2022 "As important drug targets, G protein-coupled receptors (GPCRs) play pivotal roles in a wide Extensive efforts of structural biology have been made on the study of GPCRs. However, a large portion of GPCR structures remain unsolved due to structural instability. Herein we evaluated the accuracy of GPCR structure models predicted by AlphaFold2. Read more at the source #DrGPCR #GPCR #IndustryNews

Read more at the source #DrGPCR #GPCR #IndustryNews

August 2022 Addex and Indivior Extend GABAB Positive Allosteric Modulator Research Collaboration for US $900,000) of additional research funding. compounds for Charcot-Marie-Tooth type 1A neuropathy (CMT1A) and pain. " Read more at the source #DrGPCR #GPCR

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light on the distinct durations of signaling induced by PTH and PTHrP" Read more at the source #DrGPCR #GPCR

Confers Cholesterol-Induced Thermal Stability to the Serotonin 1A Receptor "G protein-coupled receptors (GPCRs The serotonin1A receptor is a crucial neurotransmitter receptor in the GPCR family involved in a multitude envision that our results could have potential implications in structural biological advancements of GPCRs Read more at the source #DrGPCR #GPCR #IndustryNews