Search Results
Results found for "Family B GPCRs"
- Pharmacophore-guided Virtual Screening to Identify New β 3 -adrenergic Receptor Agonists
Read more at the source #DrGPCR #GPCR #IndustryNews
- Increased Anxiety-like Behaviors in Adgra1-/- Male But Not Female Mice are Attributable to...
Pathways "Adhesion G protein-coupled receptor A1 (ADGRA1) belongs to the G protein-coupled receptor (GPCR ) family, and its physiological function remains largely unknown. Read more at the source #DrGPCR #GPCR #IndustryNews
- Primary cilia and SHH signaling impairments in human and mouse models of Parkinson’s disease
Additionally, we detect a shortening of PC in PINK1-deficient human cellular and mouse models of familial Read more at the source #DrGPCR #GPCR #IndustryNews
- Irreversible Drugs, Real Control: Design for Durable Target Engagement
Molecular innovation This Week’s GPCR Intelligence: The next edge in discovery isn’t louder exposure—it Breakthroughs this week: nanomedicines targeting PAR2 for sustained analgesia; Emerging Voices in GPCR GPCR Premium: Sneak Peek Industry insights: Confo VLAIO grant; Skye CB1 Ph2 miss; Chugai CT-388 in-license Upcoming events: Membrane-mimetic screening; GPCR Forum 2025; GPCR-TDD Summit Europe. GPCR scientists, translational pharmacologists, biotech discovery teams, and decision-makers who need
- Cholesterol-Dependent Dynamics of the Serotonin 1A Receptor Utilizing Single Particle Tracking....
September 2022 "G protein-coupled receptors (GPCRs) are signaling hubs in cell membranes that regulate Serotonin1A receptors are important members of the GPCR family and are implicated in neuropsychiatric To explore the role of cholesterol in lateral dynamics of GPCRs, we utilized single particle tracking results bring out the interdependence of cholesterol and actin cytoskeleton in regulating diffusion of GPCRs Read more at the source #DrGPCR #GPCR #IndustryNews
- Delineation of GPR15 receptor-mediated Gα protein signaling profile in recombinant mammalian cell
September 2022 "The GPR15 receptor is a G protein-coupled receptor (GPCR), which is activated by an endogenous Within the Gi/o family, the GPR15 receptor activates all the subtypes (Gi1 , Gi2 , Gi3 , GoA , GoB and Read more at the source #DrGPCR #GPCR #IndustryNews
- Orion and Peptilogics are pursuing AI-driven drug discovery to explore new functional chemical ...
and precision-engineer therapeutics with enhanced potency and tailored signaling against an undrugged GPCR #ai #drugdiscovery #gpcr" Read more at the source #DrGPCR #GPCR #IndustryNews
- GBCRdb for beginners
Join us for a fantastic introduction to GPCRdb with Dr. David Gloriam and Dr. Albert Kooistra. Register today: https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe/ #gpcr #drgpcr #virtualcafe
- Interacting binding insights and conformational consequences of the differential activity of...
is able to modulate different receptors in the endocannabinoid system, some of which belong to the family of G-protein-coupled receptors (GPCRs). Notably, while CBD is able to antagonize some GPCRs in the endocannabinoid system, it also seems to activate we investigate the interacting determinants of CBD in two closely related endocannabinoid-activated GPCRs Read more at the source #DrGPCR #GPCR #IndustryNews
- Biphasic activation of β-arrestin 1 upon interaction with a GPCR revealed by methyl-TROSY NMR
β-arrestins (βarrs) play multifaceted roles in the function of G protein-coupled receptors (GPCRs). βarrs typically interact with phosphorylated C-terminal tail (C tail) and transmembrane core (TM core) of GPCRs changes for βarr activation upon the C tail- and TM core-mediated interactions with a prototypical GPCR This plasticity of βarr conformation in complex with GPCRs engaged in different binding modes may explain
- All About Addgene: More Open and Reproducible Science with Materials Sharing
GPCR Virtual Cafe? Register today! Addgene's Dr. Joanne Kamens is our guest. research or you want to share your materials, this is the place to go. https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe / #gpcr #drgpcr #virtualcafe #addgene
- Location bias contributes to functionally selective responses of biased CXCR3 agonists
November 2022 "Some G protein-coupled receptor (GPCR) ligands act as "biased agonists" that preferentially Although GPCRs are primarily found at the plasma membrane, GPCRs can traffic to and signal from many subcellular signaling contributes to the biased signaling generated by three endogenous ligands of the GPCR observed at CXCR3, which has important implications for drugs targeting chemokine receptors and other GPCRs Read more at the source #DrGPCR #GPCR #IndustryNews Subscribe to the Dr. GPCR Newsletter HERE
- Molecular basis for variations in the sensitivity of pathogenic rhodopsin variants to 9-cis-retinal
Read more at the source #DrGPCR #GPCR #IndustryNews Subscribe to the Newsletter HERE
- G-protein-coupled receptors as therapeutic targets for glioblastoma
In this review, we focus on recent advances in G-protein-coupled receptor (GPCR) targets.
- High hedgehog signaling is transduced by a multikinase-dependent switch controlling the...
signaling is transduced by a multikinase-dependent switch controlling the apico-basal distribution of the GPCR smoothened "The oncogenic G-protein-coupled receptor (GPCR) Smoothened (SMO) is a key transducer of of HH to the apico-basal distribution of SMO and provide a novel mechanism for the regulation of a GPCR Read more at the source #DrGPCR #GPCR #IndustryNews
- Case Report of a Juvenile Patient with Autism Spectrum Disorder with a Novel Combination of Copy...
Read more at the source #DrGPCR #GPCR #IndustryNews
- Recurrent hypoglycemia increases hepatic gluconeogenesis without affecting glycogen metabolism or sy
hypoglycemia, we first checked expression of counterregulatory hormone G-protein coupled receptors (GPCRs regulators and downstream enzymes catalyzing glycogen metabolism, gluconeogenesis and lipolysis by qPCR Read more at the source #DrGPCR #GPCR #IndustryNews
- Production of human A2AAR in lipid nanodiscs for 19F-NMR and single-molecule fluorescence...
describe production of the human A2A adenosine receptor (A2AAR), a class A G protein-coupled receptor (GPCR Read more at the source #DrGPCR #GPCR #IndustryNews
- Use of CRISPR/Cas9-edited HEK293 cells reveals that both conventional and novel protein kinase C...
are involved in mGlu5a receptor internalization "The internalization of G protein-coupled receptors (GPCRs Additionally, using the Gαq/11 inhibitor YM-254890, GPCR kinase 2 and 3 (GRK2 and GRK3) KO cells, and Our PKC KO cell lines expand the repertoire of KO HEK293A cell lines available to research GPCR pharmacology Read more at the source #DrGPCR #GPCR #IndustryNews
- Function and structure of bradykinin receptor 2 for drug discovery
October 2022 "Type 2 bradykinin receptor (B2R) is an essential G protein-coupled receptor (GPCR) that Read more at the source #DrGPCR #GPCR #IndustryNews
- Specific Functions of Melanocortin 3 Receptor (MC3R)
October 2022 "Melanocortin 3 receptor (MC3R) is a G-protein coupled receptor (GPCR) that is defined Read more at the source #DrGPCR #GPCR #IndustryNews
- GPR15 expressed in T lymphocytes from RA patients is involved in leukocyte chemotaxis to the...
GPR15 is a G protein-coupled receptor (GPCR) located on chromosome 3 and has similarity in its sequence The expression of GPR15 and c10orf99/gpr15l mRNA was analyzed by RT-qPCR. Read more at the source #DrGPCR #GPCR #IndustryNews
- G protein-coupled receptor signaling: transducers and effectors
October 2022 "G protein-coupled receptors (GPCRs) are of considerable interest due to their importance dynamic structures, and physiological relevance in the cardiovascular system of the three most important GPCR signaling effectors: heterotrimeric G proteins, GPCR kinases (GRKs), and β-arrestins. As new technologies are developed and applied to studying GPCR structure and their downstream effectors Read more at the source #DrGPCR #GPCR #IndustryNews
- Pharmacological targeting of cGAS/STING-YAP axis suppresses pathological angiogenesis and...
STING-YAP signaling by both a small-molecule STING agonist, SR-717, and a G protein-coupled receptor (GPCR Read more at the source #DrGPCR #GPCR #IndustryNews
- Protein Uncoupling as an Innovative Practice in Diabetes Mellitus Treatment: A Metabolic Disorder
Read more at the source #DrGPCR #GPCR #IndustryNews
- Although the cannabinoid type-2 receptor (CB2) is highly expressed in the immune system, emerging...
Read more at the source #DrGPCR #GPCR #IndustryNews
- Synthesis and characterization of an orally bioavailable small molecule agonist of the apelin recept
pentan-3-yl)-1-cyclopentyl-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxamide hydrochloride) of this GPCR Read more at the source #DrGPCR #GPCR #IndustryNews
- Fluorescent Ligands Targeting Intracellular Allosteric Binding Site of the Chemokine Receptor CCR2
"Fluorescently labeled ligands are versatile molecular tools to study G protein-coupled receptors (GPCRs targeting the intracellular allosteric binding site (IABS) of the CC chemokine receptor 2 (CCR2), a class A GPCR Read more at the source #DrGPCR #GPCR #IndustryNews
- Exploring pharmacological inhibition of G q/11 as an analgesic strategy
Read more at the source #DrGPCR #GPCR #IndustryNews
- RGS7-ATF3-Tip60 Complex Promotes Hepatic Steatosis and Fibrosis by Directly Inducing TNFα
Signaling 7 (RGS7) in hyperlipidemia-dependent hepatic dysfunction. " Read more at the source #DrGPCR #GPCR
