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Results found for "John R Hepler"
- Nanobodies: New Dimensions in GPCR Signaling Research
S., Schnapp, A., Konetzki, I., Sunahara, R. K., Gellman, S. H., Pautsch, A., Steyaert, J., Weis, W. R., Venkatakrishnan, A. J., Jude, K. M., Dukkipati, A., Feinberg, E. N., Angelini, A., Waghray, D., Dror, R. O., Ploegh, H. L., & Garcia, K. C. (2015).
- New Tools, Smart Signals, and The Kenakin Brief
Get a sneak peek and sign up for The Kenakin Brief—his free weekly newslette r.
- GPCR Weekly Whirlwind: Top Receptor Highlights from Sep 30 - Oct 6, 2024!
Take action immediately to join our esteemed learning community! from September 30th to October 6th, 2024 Industry News Nxera Pharma appoints experienced commercial R& Molecular Insights into GPCR Function LYCHOS is a human hybrid of a plant-like PIN transporter and a GPC R
- How to Design GPCR Drugs That Work in Vivo: Strategy, Tools, and Insights
Career opportunities: Senior Scientist, Phage Display | Manager, CMC Management | Translational R&D Join Premium for access to expert tools, translational strategy, classified updates, and curated jobs—trusted by scientists, teams, and biotech decision-makers. 🚀 Join Premium Today & Enjoy ➤ 🎓 Full GPCR University
- Decoding β-Arrestins: from Structure to function
conformation-selective probes for monitoring activation-induced changes in cellular environments (Irannejad, R. A., et al. 1997, Bohn, L. M. et al. 1999), while dual knockout is lethal (Schmid, C. L., & Bohn, L. conformational changes for the binding to the same GPCR to mediate differential regulatory effects (Haider, R. various processes, and their imbalance is linked to pathological conditions, including cancer (Gros, R.
- 📰 GPCR Weekly News
Multi-target Collaboration and License Agreement in Diabetes and Metabolic Diseases Sosei Heptares Enters R& Treating Type 2 Diabetes and Obesity Special report 2022: Meet 20 women blazing trails in biopharma R&
- Molecular creativity in drug discovery
. 🟢 Premium Members get 50%+ discount when they join Terry’s Corner. 👉 Access this week’s key insight Highlights: • The Foundry Arrives : R&D meets biotech with real-world acceleration, strategic consulting
- Identification of hub genes in the subacute spinal cord injury in rats
differentially expressed genes (DEGs) and weighted correlation network analysis (WGCNA) were performed using R
- Ode to GPCRs
A. & Kyle, R. A. Sir Bernard Katz--winner of Nobel Prize in physiology or medicine. C. & Bond, R. A. Sir James Whyte Black OM. 14 June 192422 March 2010. Eric R. Chemistry, R. S. of. R. B. & Irannejad, R.
- A Note from Yamina: Building the Next Chapter of Dr. GPCR
GPCR Foundry — our R&D and biotech hub designed to bridge GPCR science with execution. The Dr. Learners can study at their own pace, shape the curriculum, and join live monthly AMA sessions with Dr Anyone who joins Premium before these changes go live will be grandfathered at their current rate , as
- 📰 GPCR Weekly News, June 10 to 16, 2024
John Teye Azietaku for his contributor article on Unveiling GPCR Priming: The Hidden Synergy in Cellular Join us in vibrant Mexico City from October 23 to 25, 2024, for this key event in adhesion GPCR Biology Science Post-Doctoral Fellow—Pharmacology/Cell Biology/Biochemistry Post Doctoral Fellow Postdoc Position Join
- Sosei Heptares Confirms Senior Leadership Changes to Drive the Company Through the Next Stage ...
Matt Barnes appointed President of Heptares Therapeutics Ltd., and Head of UK R&D Tokyo, Japan and Cambridge
- Sosei Heptares recently hosted their annual Scientific Advisory Board (SAB)
It was great to bring everyone together and also welcome new member John Parkinson."
- From Technician to Trailblazer: How Sokhom Pin Designed His Own PhD Program While Working in Industry
As a lab technician at Johns Hopkins, he was fascinated by science but also grounded in real-life responsibilities
- 📰 GPCR Weekly News, June 24 to 30, 2024
Methods for the Optimization of Candidate Selection Dates: October 3rd to 31st, 2024 GPCR Event Highlight Join Receives US$10 Million from AbbVie as Collaboration Targeting Neurological Diseases Achieves First R& Pharmacology (FDE) Research Assistant Senior Scientist - Receptor Pharmacology Postdoctoral Scientist Join
- When Pain Becomes a Catalyst: How Personal Experience Redefined One Scientist’s Mission
His new obsession led him to Johns Hopkins, where he worked in the lab of Dr.
- Accelerating GPCR Drug Discovery: What 40 Years of Pharmacology Reveal
to do: bring four decades of frontline discovery insight straight to discovery-phase scientists and R& How better CRO communication prevents costly errors. 👉 Join Terry’s Corner & Secure Your Spot for the
- Unlocking Cell's Secrets: Spontaneous β-Arrestin-Membrane Preassociation Drives Receptor-Activation
M., Medel-Lacruz, B., Baidya, M., Makarova, M., Mistry, R., Goulding, J., Drube, J., Hoffmann, C., Owen Cell, 186(10), 2238–2255.e20. https://doi.org/10.1016/j.cell.2023.04.018 Janetzko, J., Kise, R., Barsi-Rhyne
- Orthosteric vs. Allosteric Interactions: The Silent Decider of Safety and Success
Every R&D team is under the same pressure: deliver validated targets, clean pharmacology, and translatable 👉 Explore Trailers & Join Today Why Terry’s Corner The reality is dynamic—ligands compete, cooperate
- 📰 GPCR Weekly News, April 10 to 16, 2023
Join us for the upcoming Dr. GPCR Symposium on GPCR Activation and Signaling on May 19th, 2023. GPCR Binders, Drugs, and more Discovery of SYD5115, a novel orally active small molecule TSH-R antagonist
- Feeder or trigger – CCR2 as a scavenger and regulator of cell migration
responsiveness of canonical G protein–coupled chemokine receptors that bind to the same ligand(s) (R. Wang et al. 2009; R. J.
- Embark on a GPCR Adventure: Your Weekly Research Expedition! | Oct 21-27, 2024
This Week’s Highlights: Congrats to: John Teye Azietaku , our great contributor, for his article Class
- 📰 GPCR Weekly News, January 8 to 14, 2024
GPCR University February 8 - 29: Join Dr. GPCR University's live course with Dr. Terry Kenakin. April 22 - 23, 2024 | Endocrine Metabolic GPCRs Join us at the Endocrine Metabolic GPCRs event on April MolFlux: Empowering the ML Community in Molecular Predictive Modelling NanoImaging Services Appoints John
- Targeted Drug Design through GPCR Mutagenesis: Insights from β2AR
R., ... & Manglik, A. (2024).
- Chemical Drug Matter : Rethinking the Molecules We Choose to Develop In Drug Discovery
is strategic, method-proven insight for discovery teams, pharmacologists refining core skills, and R&
- Your GPCR Program Decisions Depend on Good Data Interpretation
and startup environments Read Maria Majellaro's Full Recap ➤ Lab Leadership Without Ego: A Model for R&
- Optimizing HTRF Assays with Fluorescent Ligands: Time-Resolved Fluorescence in GPCR Research
unspecific binding measurement (specific binding measured using CP55490 at 10 μM concentration ) (b) CB 2 R
- 🎄 Have Yourself a Merry Little GPCRmas! ❄ Dec 9 - 15, 2024
contributes to inflammatory joint pain Luke A Pattison , Rebecca H Rickman , Graham Ladds , Ewan St John
- Advantages of Fluorescent Probes in GPCR Assays
Sridharan R, Zuber J, Connelly SM, Mathew E, Dumont ME.
- VAMP2: a crucial player in the delivery of MOR to the synapse
Wickner, W., and R. Schekman. 2008. Membrane fusion. Nat. Struct. Mol. Biol. 15:658–664.


















