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This week's Premium content offers a curated look at what's moving the industry and scientific community GPCR Podcast : The Future of GPCR Drug Discovery with Molecular Modeling The field of GPCR research is This is a critical opportunity for the scientific community to come together and share new findings on Connect with experts:  Join a community of like-minded field-experts dedicated to improving our collective Kenakin) teaming up with the best GPCR community platform to help train and inspire the next generation

Exploring the intracellular allosteric site GPCRs represent one of the largest and most vital families For this reason, GPCRs have been a focus of drug development for decades due to their role in regulating GPCR activity, enabling greater specificity and fewer side effects. Recent advances in structural biology have allowed researchers to visualize the binding of allosteric allosteric site common in class A and class B GPCRs, particularly in chemokine receptors.

research from descriptive science into predictive decision-making. GPCR Modeling in Context: Then and Now When Carlsson entered the GPCR field in the early 2000s, structural Why Predictive GPCR Modeling Matters Now The convergence of machine learning, improved GPCR structures But success depends on researchers who can manage expectations, build trust, and integrate across disciplines Want to go deeper into GPCR modeling? Dr.

moments that changed everything. 👉 Discover the pHSense™ Reagents + Listen to the podcast ➤ Celtarys Research A new contributor article from our friends at Celtrays Research outlines how dual-labeled fluorescent GPCR innovation is accelerating. University + 🔬 200+ expert talks 🗞️ Weekly research, careers & event intelligence 🤝 Members-only networking, AMAs & matchmaking 💡 Support open resources for the global GPCR field 🧠 Designed for researchers

Welcome back GPCR fans, If your drug discovery strategy still relies on static GPCR models, you’re already Upcoming events:  GPCR-UK Network Meeting, neuroGPCR symposium, and Transatlantic ECI GPCR event—where Position your research for maximum visibility.   Register for Discovery On Target ➤ What our community is saying “I enjoy the breadth of questioning that GPCR Podcast Listener Why Dr.

2026 GPCR Pharmacology AMA: Receptor Theory, Biased Signaling & Assay Interpretation The first GPCR Pharmacology interpretation, biased signaling, and practical drug discovery challenges — driven by questions from the community objective is straightforward: Make mechanistic pharmacology easier to access, revisit, and apply across research as new videos are released: ▶️ https://www.youtube.com/@TerryPharmacologyCorner New White Paper on GPCR School of Medicine, has authored a new white paper in collaboration with Eurofins DiscoverX: Assess GPCR

GPCR Forum Start a lively chat or request help with your research! GPCR community members Join the GPCR fan club and geek out with fellows! So much more to come! This change is all about keeping our community strong and delivering top-notch content. It'll help us keep things running smoothly and grow our community. AlloViz: A tool for the calculation and visualisation of protein allosteric communication networks GPTrans

The GPCR ship is setting sail on a grand voyage across the vast ocean of research. We are dedicated to enhancing our community and delivering exceptional services to achieve our goal GPCR courses GPCR Forum Start an engaging discussion or request help in your research. GPCR community members Build connections with other GPCR fans :) So much more to come! mechanosensing Senior Scientist, GPCR Pharmacology Research Associate - Professor Graeme Milligan Postdoc

Introduction Dopamine receptors are G-protein-coupled receptors (GPCRs), which have 5 subtypes -D1-5. Thus, developing assays for commercially available probes such as CELT-419 would facilitate research Fluorescence anisotropy (FA) assay has been used to study the ligand binding kinetics of many GPCRs.[ For example, a Cy5-labelled fluorescent ligand with the same pharmacophore is available from Celtarys Research methods can increase the quality and quantity of both fundamental receptor research and high-throughput

In GPCR drug discovery, a single mistaken assumption can derail an entire program. Why Misreading Antagonism Delays GPCR Drug Discovery If a dose-response curve shifts to the right, you Common misconceptions  arise when irreversible binding, receptor reserve, or allosteric effects mimic Why now:  GPCR research is accelerating—and the projects that succeed will be those built on clear, accurate

GPCR research requires turning data into insights for drug discovery Hi GPCR Friends, Every week, critical decisions in GPCR research hinge on subtle shifts in data. GPCR Podcast – Ajay Yekkirala on GPCR Innovation In this episode, Dr. Be part of the nonprofit mission to unite the GPCR community. The pace of GPCR innovation is accelerating.

By combining fiber photometry with FRET-based biosensors, we were able to track GPCR-dependent signaling Hence, it has wide applicability across a spectrum of neuroscience research, ranging from the study of Read more at the source #DrGPCR #GPCR #IndustryNews

GPCR podcast is now available! Our guest is Mark Schmeizl! Listen where you get your podcasts https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ #drgpcr #gpcr #podcast

G protein-coupled receptors (GPCRs) are integral membrane proteins crucial for sensing extracellular Despite their immense potential, utilizing FRET and BRET sensors in GPCR research comes with challenges In conclusion, FRET and BRET-based sensors have transformed the landscape of GPCR research, offering unprecedented insights into the intricacies of GPCR signaling. Nature Communications, 2016. 7(1): p. 12178. 11.    Strungs, E.G., L.M. Luttrell, and M.H.

GPCR podcast is now available! Our guest is Dr. Adriano Marchese! Learn about his remarkable career and research in #GPCR signaling and trafficking. Listen where you get your podcasts https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ #drgpcr #gpcr #podcast

What emerged wasn’t just another pharmacology group — it became a collaborative engine for GPCR discovery Why This Matters GPCR research demands integration — pharmacology, structural biology, signaling pathways This ecosystem outlasted individual PIs  and became a GPCR innovation hub  with global reach. GPCR science thrives in complexity — meaning no single lab or company can do it alone. GPCR Premium  for deep dives, strategic tools, and behind-the-scenes conversations shaping the GPCR field

GPCR Ecosystem paid membership with extra benefits? 🔬Join the #GPCR movement today! ➡️ https://www.ecosystem.drgpcr.com/plans-pricing #gpcr #drgpcr

May 2022 "Seoul, South Korea, 28 April 2022 – GPCR therapeutics, Inc., a venture-backed clinical stage company with an innovative approach to drug discovery based on targeting G Protein Coupled Receptors (GPCR Jon Wigginton will provide scientific expertise to support the company’s research and clinical development GPCR just had a very successful first meeting including all the Scientific Advisory Board." Read more at the source #DrGPCR #GPCR #IndustryNews

of GPCR research and drug discovery. Must-read publications:  Stay updated on cutting-edge research, including the potentiation of GPCR signaling Catherine’s research, blending GPCR signaling studies with public health data, offers critical insights Why contribute: Join a global, like-minded GPCR community. community platform to help train and inspire the next generation of scientists.” — Dr.

GPCR activation typically occurs through the binding of agonists which stabilize receptor conformations GPCR targeting drugs: orthosteric vs allosteric sites Most of the drugs targeting GPCRs bind to the orthosteric GPCRs functional selectivity Recent research has revealed a more intricate understanding of GPCR behavior Agonist binding to GPCRs doesn't always trigger all associated events sequentially. selectively activate specific cellular outcomes linked to that GPCR.

Join us and learn how to quantify your kinetic GPCR signaling from the expert himself: Dr. https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe/ #gpcr #drgpcr #virtualcafe

Hello GPCR Trailblazers, This week, we’re spotlighting Celtarys Research, our newest partner, featured GPCR will help researchers move faster with custom fluorescent ligands, translational insight, and tool-enabled Introducing Celtarys - Probe Development via Conjugation Strategies   Celtarys Research's first article Explore this week’s research, tools, and biotech insights in one place. The insights are ready. GPCR Team

August 2022 "The common mechanisms by which members of the G protein-coupled receptor (GPCR) family respond However, it is becoming increasingly clear that GPCRs show great diversity in their intracellular location Here we will discuss recent studies on the diversity of location, effectors, and signaling of GPCRs, and how these could interact to generate specific spatiotemporal patterns of GPCR signaling in cells. Read more at the source #DrGPCR #GPCR #IndustryNews

Rho1 signaling is activated by G-protein-coupled receptor (GPCR) signaling at the cell surface. During Drosophila embryonic salivary gland (SG) invagination, the GPCR ligand Folded gastrulation (Fog Here, we reveal that the Smog GPCR transduces Fog signal to regulate Rho kinase accumulation and myosin Read more at the source #DrGPCR #GPCR #IndustryNews

of how residence time—not potency—predicts therapeutic coverage ✅ Insight into cryptic intracellular GPCR evaluating scaffold permeability using modern, cost-effective pharmacokinetic assays   Why Intracellular GPCR Drugs Change the Game For decades, drug design has treated GPCRs as surface targets. GPCRs now have validated intracellular  allosteric sites. Subscribe to The Kenakin Brief today  ➤ #GPCRs #IntracellularDrugs #DiffusionBarriers #DrugResidenceTime

β-arrestin1 and 2 exhibit distinct phosphorylation-dependent conformations when coupling to the same GPCR cells "β-arrestins mediate regulatory processes for over 800 different G protein-coupled receptors (GPCRs ) by adopting specific conformations that result from the geometry of the GPCR-β-arrestin complex. However, whether β-arrestin1 and 2 respond differently for binding to the same GPCR is still unknown. Read more at the source #DrGPCR #GPCR #IndustryNews Subscribe to the Dr. GPCR Newsletter

GPCR podcast is now available! Our guest is Dr. Mark Connor! Learn more about #GPCRs and life as an academic wearing different hats. Listen nowhere you get your podcasts. https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ #gpcr #drgpcr

GPCR Ecosystem with a paid membership for extra benefits. Catch up with the latest #GPCR news, our monthly Virtual Cafe, and much more! Join the #GPCR movement today! ➡️ https://bit.ly/3SUkB8D

GPCR Podcast, we have none other than Dr. Marta Filizola! https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ #gpcr #drgpcr #podcast

Rho1 signaling is activated by G-protein-coupled receptor (GPCR) signaling at the cell surface. During Drosophila embryonic salivary gland (SG) invagination, the GPCR ligand Folded gastrulation (Fog Here, we reveal that the Smog GPCR transduces Fog signal to regulate Rho kinase accumulation and myosin Read more at the source #DrGPCR #GPCR #IndustryNews