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  • Understanding Enzyme Inhibition In GPCR Discovery Programs

    Plus: top tracks to watch at GPCR Forum 2025, fresh postdoc openings at the ADME/signaling interface Mastering inhibition isn’t just about avoiding drug–drug interactions. Kenakin Trusted insights across biotech, pharma, and academia 💎 $2,999/year — one conference cost = embracing serendipity, Eric shares the mindset (and messy origin stories) that shaped tools now used across biotech GPCR scientists, translational pharmacologists, biotech discovery teams, and decision-makers who need

  • Inverse Agonists, Lymphatic Fixes & β-arrestin Tricks

    GPCR tools and key moves in the biotech world. Dr. Explore this week’s research, tools, and biotech insights in one place.

  • Mapping Motion: Intermediate States, Deorphanization & Discovery

    Meanwhile, the industry is moving fast with AI-powered platforms, bold leadership moves, and strategic biotech Explore this week’s research, tools, and biotech insights in one place.

  • Immunomodulatory Role of Neuropeptides in the Cornea

    with its dense sensory innervation and resident leukocyte populations make it an ideal tissue to study interactions of neuropeptide signaling and how it contributes to pathophysiology, which is likely due to complex interactions

  • Dr. GPCR and Celtarys Research Join Forces to Expand Access to Innovative GPCR Tools

    “These tools can dramatically improve how scientists measure ligand-receptor interactions, visualize About Celtarys Research Celtarys Research is a biotech company based in Spain that specializes in the

  • GPCR Drug Discovery at Discovery on Target: Why This Track Is About More Than Receptors

    Discovery at Discovery on Target 2025 — The Track You Can’t Miss If you work in drug discovery  or biotech Over the years, we’ve built a global network of researchers, biotech leaders, and pharma innovators who together. 🚨 Mark your calendar for the GPCR Happy Hour Join us at GPCR Happy Hour , where scientists, biotech

  • How to Use Statistical Methods to Strengthen Every GPCR Drug Discovery Decision

    Ajay Yekkirala shares the journey from academic pharmacologist to biotech entrepreneur—bridging curiosity When the global biotech crowd lands in Boston for Discovery on Target. GPCR scientists, translational pharmacologists, biotech discovery teams, and decision-makers who need

  • Terry’s Corner, Celtarys' Leap, and the $7B GPCR Horizon

    Tools The Story Behind Celtarys – From Chemistry to Company   How does a medicinal chemist become a biotech Explore this week’s research, tools, and biotech insights in one place.

  • 📰 GPCR Weekly News, March 20 to 26, 2023

    receptor against polycystic kidney disease GPCRs in Oncology and Immunology Purinergic GPCR-integrin interactions Industry News Domain Therapeutics was one of the 4 Biotech Trophy nominees at 2023 HealthTech awards. The delisting dilemma: Why do so many biotechs face being kicked off the Nasdaq?. (April 20 - 21, 2023) Swiss Biotech Day (April 24 - 25, 2023) SLAS Europe 2023 Conference and Exhibition

  • Use of CRISPR/Cas9-edited HEK293 cells reveals that both conventional and novel protein kinase C...

    reveals that both conventional and novel protein kinase C isozymes are involved in mGlu5a receptor internalization "The internalization of G protein-coupled receptors (GPCRs) can be regulated by PKC. isozymes (ΔcPKC and ΔnPKC) and employ these to investigate the contribution of PKC isozymes in the internalization Nonetheless, we determined that mGlu5a internalization was not altered upon the loss of cPKCs or nPKCs motif, we demonstrate that internalization of rat mGlu5a is mediated by Gαq/11 proteins (77% of the

  • A Note from Yamina: Building the Next Chapter of Dr. GPCR

    GPCR Foundry  — our R&D and biotech hub designed to bridge GPCR science with execution. The Dr. GPCR Foundry: Science Meets Execution The Foundry is where we bring together biotech innovators, Venture , he shares decades of expertise in an accessible, on-demand format for scientists across academia, biotech

  • Dr. GPCR Updates

    Dive into this week’s research, tools, and biotech updates all in one place.

  • Beyond Clearance: The Strategic Power of Irreversible Drug Binding

    When a drug outlives its exposure , toxic interactions can be just as persistent as therapeutic ones. Such interactions can disrupt metabolic detoxification and lead to delayed, systemic toxicity. Kenakin Content trusted by biotech, pharma, and academia 💎 $2999/year — one conference cost = a full Irreversible binding can turn enzyme interactions into make-or-break kinetic events. Kenakin with your own enzyme or GPCR interaction puzzles.

  • From Lab Bench to Boardroom: The Unexpected Path of a Medicinal Chemist

    Watch Episode 168 What does it take for a scientist to become a startup leader in biotech? For Dr.

  • Molecular creativity in drug discovery

    Highlights: • The Foundry Arrives : R&D meets biotech with real-world acceleration, strategic consulting GPCR scientists, translational pharmacologists, biotech drug discovery teams, and decision-makers who

  • Lab Leadership Without Ego: How Sokhom Pin Built the Happiest Team at Alkermes

    His team was known internally as the “happiest group at Alkermes.” work at Alkermes didn’t just improve drug screening outcomes, it redefined what great leadership in biotech

  • How System-Level GPCR Thinking Prevents Discovery Failures

    next-generation fluorescent probes—designed with precise synthetic logic—enable deeper insight into GPCR internalization GPCR Premium Membership Gives You an Edge Premium gives GPCR scientists and biotech teams a single, trusted Researchers, pharmacologists, biotech teams, and decision-makers who rely on accurate, efficient, interpretation-first

  • How GPCR Collaboration Built an Innovation Engine

    signaling platforms launched Year 4  — Pooled grants fund expansion and training programs Year 7  — International Biotech teams, CRO alliances, and academic consortia face the same challenge: how to align incentives This ecosystem design blueprint applies to biotech teams and academic consortia alike.

  • 📰 GPCR Weekly News, January 1 to 7, 2024

    Inês Pinheiro and Oliver Hartley from the Orion Biotechnology team on their recent study on Arylsulfatases Enter Agreement for Rhythm to Acquire Global Rights to Oral MC4R Agonist LB54640 Addex to Present at Biotech Showcase™ 2024 Establishing our first international translational research project - Institute for Protein Conference Isomorphic Labs Announces Strategic Multi-Target Research Collaboration With Novartis Salipro Biotech Meetings, and Webinars January 16 - 19, 2024 | 23rd Annual PEP Talk February 3 - 7, 2024 | SLAS2024 International

  • Irreversible Drugs, Real Control: Design for Durable Target Engagement

    Kenakin Trusted insights from biotech, pharma, and academia 🎬 Plus New: Lesson Trailers   Curious about GPCR scientists, translational pharmacologists, biotech discovery teams, and decision-makers who need

  • From Technician to Trailblazer: How Sokhom Pin Designed His Own PhD Program While Working in Industry

    His hybrid path is a model of possibility for professionals in the biotech industry who still dream of

  • Predicting GPCR Function: Inside the Carlsson Lab’s Modeling Toolbox

    Can we leverage structural and computational insights not just to explain receptor–ligand interactions The “Predict, Not Explain” Ethos What sets the Carlsson lab apart is its internal rule : results must It struggles with ligand-bound conformations, GPCR–G protein complexes, and receptor–peptide interactions Translational Impact for Drug Discovery While the Carlsson lab is rooted in academia, its impact extends into biotech

  • Subscribe to Dr. GPCR Newsletter Today!

    Did you know that each month we collect the most recent #GPCR publications and the newest Biotech/Pharma

  • Are You Guessing or Forecasting? Master GPCR Pharmacologic Models Before It’s Too Late

    🔹 Spot the opportunity → Why Catalio is betting big when others pull back Amid biotech slowdowns

  • New Podcast, Sweet Structures & $2.2B GPCR Moves

    Explore this week’s research, tools, and biotech insights in one place.

  • Inversago Pharma appoints Glenn S. Vraniak as Chief Financial Officer

    (“Inversago”), a clinical stage biotech company with a unique portfolio of CB1 inverse agonists, today Vraniak served as Chief Financial Officer of Evaxion Biotech A/S, an AI enabled immuno-oncology company

  • Embark on a GPCR Adventure: Your Weekly Research Expedition! | Oct 21-27, 2024

    School of Medicine to Receive $3-Million Award from ARPA-H’s Sprint for Women’s Health Nxera Pharma Wins Biotech Year and Financing Deal of the Year at the Citeline Japan Awards 2024 GPCR therapies: Eight promising biotechs

  • Your GPCR Program Decisions Depend on Good Data Interpretation

    At this international meeting, leaders shared next-gen strategies shaping modern drug discovery: Prof productive lab—it accelerated outcomes and laid the cultural foundation for the next generation of biotech insights from major conferences, emerging research, and expert commentary Whether you’re a pharmacologist, biotech

  • How Advanced GPCR Kinetics Sharpen Decision Making (and Save You Time)

    ); selectivity frameworks for β₂ vs β₁ adrenergic receptors tp structural insights into cholesterol interactions binding to functional sites, live-cell compatibility, and higher specificity enable real-time tracking of interactions , internalization, and biased signaling—without fixation or permeabilization. GPCR scientists, translational pharmacologists, biotech discovery teams, and decision-makers who need

  • Signals in Motion: Pain, Metabolism & Terry’s Corner

    Explore this week’s research, tools, and biotech insights in one place.

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