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Shampo, M. A. & Kyle, R. A. Sir Bernard Katz--winner of Nobel Prize in physiology or medicine. Ekaterini Tiligada, C., Tiligada, E. & Ennis, M.

various cellular processes such as cell proliferation, migration, apoptosis, and transcription via canonical

Aaron Sato, Chief Scientific Officer at Twist Bioscience, elaborates.

All CKRs studied show the canonical active conformation, except CX3CR1 which displays a significantly As a result of the unique active conformation, the residues in the microswitch network show non-canonical The Non-canonical Toggle Switch 6.48 - CCR6 as a model CKR The structure of CCR6 bound to CCL20 reveals the "toggle switch" position 6.48 and the disruption of a hydrogen-bond network surrounding this non-canonical

7TM-independent functions of Latrophilins are essential for neuronal physiology, possibly complementing canonical

highly-conserved GPCR-autoproteolysis-inducing (GAIN) domain, the latter of which is located immediately before a canonical

Targeting GRK2 and GRK5 for treating chronic degenerative diseases: Advances and future perspectives Non-canonical

Aaron McGrath from Takeda   🎥 Interview with Kris Borzilleri & Alison Heick Varghese from Pfizer 🎥

Must-read publications:  A structural modeling study revealing non-canonical mechanisms of chemokine-driven

effectors along the Gαq/Phospholipase C (PLC) pathway, which results in an IkB kinases (IKK)-mediated canonical

non-cognate G proteins can enhance the coupling efficiency of cognate G proteins to GPCRs, thereby amplifying canonical

genes unveiled via RNA polymerase II degradation Growth factor-dependent phosphorylation of Gαi shapes canonical

Activation and Signaling Pathophysiological significance and modulation of the transient receptor potential canonical

pharmacology' Yao Lu and colleagues work on 'Molecular insights into orphan GPCRs relevant to schizophrenia' Carole

Industry News Professor Dame Carol Robinson Received 2023 ASMS John.B.Fenn Award Exscientia Announces

Carbon dioxide-induced decrease in extracellular pH enhances the production of extracellular matrix components

Small-molecule targeting of GPCR-independent non-canonical G protein signaling inhibits cancer progression

We’ve also highlighted the latest research on non-canonical internalization mechanisms of mGlu receptors

Leukotriene B4 receptor 2 governs macrophage migration during tissue inflammation From odor to oncology: non-canonical

Chemistry GPCR Activation and Signaling SNX9 family mediates βarrestin-independent GPCR endocytosis A non-canonical

Library-based screening methodology for engineering small protein GPCR ligands Paolini-Bertrand, M.

spatially selective GPCR signaling GRK5 promoted renal fibrosis via HDAC5/Smad3 signaling pathway Non-canonical

Non-canonical Golgi-compartmentalized Gβγ signaling: mechanisms, functions, and therapeutic targets.