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Experimental approach: We used a series of behavioural assays to evaluate the acute responses of mice

In a LPS-induced lung inflammation model in mice, ACT-660602 led to significantly reduced recruitment

mouse expressing a non-cleavable GPR116 mutant phenocopies the pulmonary phenotype of GPR116 knock-out mice

GPCR Activation and Signaling Cornichon protein CNIH4 is not essential for mice gametogenesis and fertility Cannabinoid tolerance in S426A/S430A x beta-arrestin 2 knock-out double mutant mice.

Finally, inhibition of Gq-GPCR coupling in mice enhanced the antinociceptive effects of morphine.

TRPM3's best understood function is its role as a peripheral noxious heat sensor in mice.

effect of CCL25 on the development of SACC in vivo was examined by a xenograft tumor model in nude mice

to E2837.39 by A4 of CCL3; c) Route 3 - characterized by steric effects between TM2 and Y3 of CCL5; d)

In adult mice, intraperitoneal ketanserin injection increased basal TrkB phosphorylation in the frontal

He has led teams that have filed more than 10 Investigational New Drug Applications (IND), as well as

protein (YAP) signaling in endothelial cells, which was evidenced by the attenuation of organ fibrosis in mice

inhibition of cell proliferation, colony formation, migration, invasion and xenograft tumor growth in nude mice

formation by PDAC cells and suppessed the growth of MiaPaCa-2 cells xenografted into the flank of nude mice

A few familiar failure points: Fragmented Data: GPCR programs spew data across files, folders, and inboxes

ARRB1 alleviates tauopathy and rescues impaired synaptic plasticity and cognitive impairments in PS19 mice

MDA-MB-231 cells are metastatic when implanted in mice while BT-20 are not and remain epithelial-like

characterized by decreased levels of proinflammatory cytokines, glial activation, and cognitive impairment in mice

have characterized the molecular mechanisms underpinning 7α,25-OHC/GPR183-induced hypersensitivity in mice

collagen-induced arthritis (CIA) were investigated to provide an explanation of why only B cells from arthritic mice

mesenchymal stromal cell secretory factor SDF-1-mediated improvement of islet function in non-obese diabetic mice

(OGR1) deficiency exacerbates crystal deposition and kidney injury in oxalate nephropathy in female mice

current experiments focus on outcomes such as respiratory rate, tidal volume, and oxygen saturation in mice

Your work belongs in the core conversation—not buried in supplementary files.

, activates mas-related G protein-coupled receptor C11 (MrgprC11) to induce scratching behaviors in mice

recordings were performed in hypoglossal MNs (HMNs) obtained from adult and neonatal rats, neonatal knockout mice

Her current work examines how these substances, when used alone or together, impair breathing in mice

RNA-seq screening and gene function analysis uncover GPR183 as a key mediator for methionine to stimulate milk

We demonstrate in male and female rats that GABAB receptors receptors alter Pr, whereas 5-HT1B receptors

In the context of MCMV latency, spleen explants from M33ΔC38-infected mice were markedly attenuated for

Oncology and Immunology A GPCR checkpoint drives CD8+ T cell dysfunction and immunotherapy failure in mice