strategy is the so-called metabolic surgery whose beneficial effects are beyond dietary restrictions and weight

Moreover, independent of glucose control or weight loss, the anti-inflammatory actions of GLP-1RAs require

If you want to share your work with our community, please don’t hesitate to fill out this form. You'll share your contributor articles with the community, stay updated with GPCR literature, join a Fragment-Based Design, Synthesis, and Characterization of Aminoisoindole-Derived Furin Inhibitors A Bright

A clear, strategic pitch doesn’t just share information. It communicates that you know who you’re building for, why now is the right time, and how your solution

affinity metrics alone, often overlooking how kinetic profiles  (onset and offset rates) fundamentally shape and how long it stays bound (k₂)  can alter therapeutic profiles dramatically, even if two candidates share Kenakin’s lecture guides you through key questions that should shape your decision-making process: Are Don’t Let Outdated Models Slow Your Next Program The analytical tools that shaped traditional affinity

That's right, you're about to level up your knowledge game! keep you on your toes  Direct line to all the cool cats in the GPCR community - Networking is key, right

Bright illumination triggered Gαt1 translocation from the rod outer to inner segments in all three transgenic

Explore discussion ➤ This Week’s Scientific Highlight GPR61, implicated in appetite and body weight regulation

Right panel, the fluorescent signal is displaced when, after incubating with CELT-327, cells are incubated

translational strategy, this is where 40 years of pharmacological insight meets the questions you’re asking right

weekly lesson help you apply key concepts like binding, signaling, and kinetics in practical, decision-shaping Maria Majellaro shares her journey to founding Celtarys in "From Lab to Leadership".

New generations of fluorophores with improved photostability and brightness will enhance assay sensitivity

But HCS only works when assays are built with rigor and powered by the right fluorescent ligands.

in Boston, the GPCR Drug Discovery track will deliver breakthroughs, bold ideas, and the strategies shaping GPCR , our mission is simple: connect the GPCR community, share knowledge, and accelerate innovation We’re helping shape the conversation. 🚀 Why GPCRs Are Still the Hottest Target Class in Drug Discovery

Chemokines are low molecular weight proteins that their functional activities are achieved by binding

Chemistry Frontiers 2025 , a conference organized by both the EFMC and the ACSMEDI, in an effort to share She has a lot of experience working for bigger businesses which she now shares as an advisor for startups Sharing the round table discussion with these excellent scientists felt like a dream come true, and Maria This Chemistry Tools session was more industry focused than those before, and Maria shared the floor This was a very enriching experience for Maria, not only did she have a chance to share Celtarys’ technology

Kenakin uses a lever analogy where: Efficacy is the weight applied.

More details will be shared soon, and registration will open in July 2024. Dr. GPCR Event Highlight We are thrilled to share the news of our in-person event in partnership with the binding genes unveiled via RNA polymerase II degradation Growth factor-dependent phosphorylation of Gαi shapes

Heptares to receive US$2.5 million milestone payment from Formosa Pharmaceuticals Are GLP-1s finding the right

Without a reversal agent for xylazine, the best defense right now is mechanistic understanding .

Rodriguez, P.J., et al., Semaglutide vs Tirzepatide for Weight Loss in Adults With Overweight or Obesity

examining GPCR science past the equilibrium snapshots, where and when receptors signal, how kinetics shape Sam Hoare  — How Signaling Kinetics Shapes GPCR Drug Action. May 14.

Our scientific team can guide you choose or design the right fluorescent ligand for your research.  

Bioscience Announces Site Relocation AI can help to speed up drug discovery — but only if we give it the right

Officer Rhythm Pharmaceuticals and LG Chem Life Sciences Enter Agreement for Rhythm to Acquire Global Rights

Let’s keep fostering a collaborative environment for sharing ideas and expanding knowledge! The presentations and discussions sparked new ideas and collaborations, shaping the future of the field

Earlier decades relied on Scatchard, Hanes, and other linear transforms to “clean” nonlinear data. Stoichiometry: The Quiet Driver of Curve Shape Two-stage systems expose how easily stoichiometry distorts When a tracer binds two sites with different affinities, curve shape reflects the ratio of affinities may see: Early stopping → potency distortions Different stopping times → incomparable datasets Curve shape Those who invest now shape the breakthroughs that follow.

focuses on how GPCR binding affinity experiments  are interpreted—and how those interpretations quietly shape This growth reflects something deeper than metrics: a shared demand for clearer interpretation, stronger

They shaped how questions were asked. Leadership, Luck, and the Lab The episode isn’t just about technology — it’s also about how careers are shaped And those who understand both the legacy and the future of GPCR work are the ones shaping the next era

Each external interaction becomes reactive, shaped more by incoming questions than by strategic intent This puts the burden of synthesis on the listener , who may not share the same context or priorities. The positioning creates a shared frame before details enter the discussion .