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July 2022 "Not even a PIPE financing could save X4 Pharmaceuticals from enacting layoffs and trimming

GPCR University We're thrilled to share that all spots for the Applying Pharmacology to Drug Discovery Exhibition February 11 - 14, 2024 | 2024 BPS Annual Meeting NEW February 20, 2024 | Career Opportunities in Pharmacology and Drug Discovery March 13 - 15 | 9th German Pharm-Tox Summit March 23 - 24, 2024 | Ligand Recognition , 2024 | 11th Adhesion GPCR Workshop July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology

GPCR University course, Applying Pharmacology to Drug Discovery, led by Dr. The course covers basic pharmacology in four weekly segments and is open to all with a free site membership Conference and Exhibition February 11 - 14, 2024 | 2024 BPS Annual Meeting NEW March 13 - 15 | 9th German Pharm-Tox , 2024 | 11th Adhesion GPCR Workshop July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology

June 2022 "CRN04894 Selected for Oral Presentation SAN DIEGO, June 8, 2022 — Crinetics Pharmaceuticals

GPCR University This week marks the beginning of our first Dr.GPCR University course, 'Applying Pharmacology Webinars February 11 - 14, 2024 | 2024 BPS Annual Meeting February 20, 2024 | Career Opportunities in Pharmacology and Drug Discovery March 13 - 15 | 9th German Pharm-Tox Summit March 23 - 24, 2024 | Ligand Recognition , 2024 | 11th Adhesion GPCR Workshop July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology

Trevena Announces Submission of New Drug Application in China for OLINVYK® by its Partner Jiangsu Nhwa Pharmaceutical The NDA was submitted by Trevena’s partner, Jiangsu Nhwa Pharmaceutical, and follows completion by Nhwa

Pharmacological chaperones are cell-permeant small molecules that engage nascent mutant GPCRs in the Therefore, CAN1404 acts as a pharmacological chaperone and can rescue cell surface expression and function effects of genetic mutations on GPCR function and provide a proof of therapeutic principle for FSHR pharmacological

GPCRs Are Optimal Regulators of Complex Biological Systems and Orchestrate the Interface between Health and Disease GPCRs arguably represent the most effective current therapeutic targets for a plethora of diseases. GPCRs also possess a pivotal role in the regulation of the physiological balance between healthy and pathological conditions; thus, their importance in systems biology cannot be underestimated. The molecular diversity of GPCR signaling systems is likely to be closely associated with disease-associated changes in organismal tissue complexity and compartmentalization, thus enabling a nuanced GPCR-based capacity to interdict multiple disease pathomechanisms at a systemic level. GPCRs have been long considered as controllers of communication between tissues and cells. This communication involves the ligand-mediated control of cell surface receptors that then direct their stimuli to impact cell physiology. Given the tremendous success of GPCRs as therapeutic targets, considerable focus has been placed on the ability of these therapeutics to modulate diseases by acting at cell surface receptors. In the past decade, however, attention has focused upon how stable multiprotein GPCR superstructures, termed receptorsomes, both at the cell surface membrane and in the intracellular domain dictate and condition long-term GPCR activities associated with the regulation of protein expression patterns, cellular stress responses and DNA integrity management. The ability of these receptorsomes (often in the absence of typical cell surface ligands) to control complex cellular activities implicates them as key controllers of the functional balance between health and disease. A greater understanding of this function of GPCRs is likely to significantly augment our ability to further employ these proteins in a multitude of diseases. Read full article

This innovation emerged from years of foundational work in photophysics and GPCR pharmacology.

Allosteric GPCR Binding Sites and Their Ligandability Potential Today, we started the Principles of Pharmacology Emerging Voices in GPCR Biology in Special Issue of Molecular Pharmacology GPCR Events, Meetings, and GPCRs-Targeted Drug Discovery Summit Europe July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology GPCR Jobs Scientist I Cell Biology - Tectonic Therapeutic Senior Scientist, GPCR Pharmacology Research Associate - Professor Graeme Milligan Postdoc in Molecular Pharmacology - The Hauser Group Postdoctoral

yes—but also a deep partnership with GPCR legend Terry Kenakin to bridge industry credibility with pharmacological That opened the door to something rare in functional pharmacology: plate-based GPCR internalization tracking internalization of endogenous GLP-1 receptors in rat beta cells—with no overexpression, no imaging, and no pharmacological

FRET-based technologies by providing high-performance fluorescent ligands designed specifically for pharmacological

Biomed Pharmacother. 2018 Feb;98:222-232. doi: 10.1016/j.biopha.2017.12.056 Azam S, Haque ME, Jakaria

This Week’s GPCR Intelligence: From Set-Point Pharmacology to No-Wash Internalization Assays This week structure-encoded location-biased signaling, GPCR signaling in metabolism, and future directions in biased ligand pharmacology GPCR scientists, translational pharmacologists, biotech discovery teams, and decision-makers who need

Career opportunities:  Snapshot of roles spanning PhD entry points to senior translational pharmacology—Protein Expression, Drug Discovery Scientist, and Staff Scientist in Molecular Pharmacology—curated with notes GPCR scientists, translational pharmacologists, biotech discovery teams, and decision-makers who need

Nordisk looks to next generation of obesity, diabetes drugs with $550M Replicate research deal; Rhythm Pharmaceuticals Associate; Senior Scientist, Data Science—curated roles aligned to GPCR discovery and translational pharmacology GPCR scientists, translational pharmacologists, biotech discovery teams, platform company leaders, and Access this week’s full Premium Edition here ➤ What our members say 🗣️ "The best pharmacology teacher Also super-valuable for those of us learning how to teach pharmacology." — DrGPCR University Attendee

. -            Biased signaling detection Biased pharmacophores may be used in conjunction with fluorescent Flow Cytometry validation performed in the Oncological Pharmacology Laboratory of the University of Turin

By the end, you’ll know how to use pharmacological models to separate lookalikes, explain puzzling outcomes When Two Mechanisms Look the Same Some of the most difficult calls in pharmacology happen when two different Built for discovery-phase teams, pharmacologists refining fundamentals, scientists challenging legacy

His work spans deep academic research, startup life, and the application of machine learning and pharmacology Superluminal Medicines: AI/ML Meets GPCR Pharmacology As Ajay continued to explore how GPCR signaling Despite decades of progress in structural biology and pharmacology, predicting how  a GPCR will respond

for proteins: Tracking the motions of cell receptors; A Better Way to Treat Obesity; Unlocking the pharmacological climbing the spotlight; new tools tracking receptor motion; obesity drug strategies shifting; antibody pharmacology Ajay Yekkirala shares the journey from academic pharmacologist to biotech entrepreneur—bridging curiosity GPCR scientists, translational pharmacologists, biotech discovery teams, and decision-makers who need

This is why fluorescent tags, both attached to the protein or to pharmacophores, are so interesting. In the case of fluorescent ligands , where a fluorescent tag is attached to a pharmacophore , the receptor studies, it facilitates the structural context necessary to map receptor localization in defined states (pharmacological Br J Pharmacol. 2023 Dec 12. doi: 10.1111/bph.16297. 

Terry's Corner - The Truth About Allosteric Displacement Allosteric binding isn’t just a twist in the pharmacology GPCR scientists, translational pharmacologists, biotech discovery teams, and decision-makers who need

Understand the synergistic mechanisms driving the escalating opioid crisis and the crucial role of GPCR pharmacology Problem Solved:  Gain a deeper understanding of the pharmacological underpinnings of opioid overdose, Listen now to understand how two mechanisms intersect—and why pharmacologists are critical in addressing GPCR scientists, translational pharmacologists, biotech discovery teams, and decision-makers who need Access this week’s full Premium Edition here ➤ What our members say 🗣️ “The best pharmacology teacher

They provide rapid and scalable assessment of pharmacological parameters.

Fluorescent Probes in GPCR assays over other methods Fluorescent ligands are made by choosing an adequate pharmacophore They can also further pharmacological and structural studies, as they can be used to determine receptor Our portfolio also includes all kinds of dyes, such as pharmacophores conjugated to near-infrared fluorophores Biomed Pharmacother. 2022 Sep;153:113408. doi: 10.1016/j.biopha.2022.113408. Br J Pharmacol. 2020 Mar;177(5):978-991. doi: 10.1111/bph.14953.

This new learning hub is your go-to space to revisit core pharmacology concepts, master new ones, and Explore Terry's Corner Better decisions start with better pharmacology.

binding pockets —sites that only exist briefly in certain receptor states—can drastically alter the pharmacokinetics Terry’s Pharmacology Corner  delivers trusted, razor-sharp insight to help drug discovery professionals Unlock “GPCRs as Allosteric Machines” Now Only in Terry’s Corner Why Terry’s Corner Terry’s Pharmacology growing, curated on-demand library Opportunities to shape future topics Built for discovery-phase teams, pharmacologists

understanding why intracellular drug access changes everything: from target residence time to diffusion-driven pharmacodynamics accessible from inside the cell ✅ Tools for evaluating scaffold permeability using modern, cost-effective pharmacokinetic In this protected environment, pharmacokinetics can decouple from plasma clearance. This opens up a new pharmacological space—and a reason to revisit “failed” targets with fresh eyes. Persistent binding isn’t just about longer half-lives—it’s about smarter pharmacology.

Born near Venice and trained as a pharmaceutical chemist, Alessandro never imagined himself working at The Early Days: Molecules and Mentors Alessandro began his academic life studying pharmaceutical chemistry

In this eye-opening module, Terry Kenakin explores a concept that could change how you interpret pharmacological