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a starting point for more ambitious questions about GPCR networks, biased signaling, and functional selectivity

And that matter shapes everything: selectivity, safety, efficacy, and innovation.

targets Constitutive activity of the dopamine receptor D5R, highly expressed in CA1 hippocampal neurons, selectively

Cannabinoid 1 (CB1 ) receptor arrestin subtype-selectivity and phosphorylation dependence. GPCR Binders, Drugs, and more Ligands selectively tune the local and global motions of neurotensin receptor

Yamina’s Corner reveals how fragmented data, undefined workflows, and ambiguous decision gates silently

If your project involves GPCRs , functional selectivity , or non-traditional ligands , this session is

Individual cancer types were enriched for highly impactful, recurrent mutations at selected cognate positions

GPCR Binders, Drugs, and more Rational design of highly stabilized and selective adrenomedullin analogs

determined by NMR via Methyl Relaxation Structural determinants of sphingosine-1-phosphate receptor selectivity

from β-arrestin interaction and demonstrates altered regulatory outcomes downstream of this functional selectivity

The impact of ACEA is inhibited by the selective CB1 receptor antagonist, rimonabant.

The potent BECN2-ATG14 coiled-coil interaction is selectively critical for endolysosomal degradation

From t-test, ANOVA, F-test selection to power analysis  that prevents underpowered studies, this module

Synthetic signaling platforms permitting precise and selective Ca2+ signal transduction can improve dissection

. 📝 Manuscript summary deadline: 23 Sept 2025 📄 Submission deadline: 11 Jan 2026 Submit to Volume II Join the conversation on computational targeting and next-gen selectivity.

GPCRs in Neuroscience Conformationally Selective 2-Aminotetralin Ligands Targeting the alpha2A- and alpha2C-Adrenergic

Submit your abstracts for poster presentation using this form - short talks will be selected from these

Industry News Arcoscreen selected by START Lausanne to pitch at the START Global summit on the 23-24th

A ligand-based peptide probe could, offer the consistency and surface selectivity GPCR imaging demands

In contrast, when the GPR55 receptor is simulated in complex with the selective agonist ML186, agonist-like

, you’ll learn how dialing receptor expression/coupling up or down reveals hidden partial agonism, “silent

In July 2025, Superluminal Medicines announced advancing a selective, biased, MC4R agonist small molecule

Traditionally, it was believed that GPCRs selectively activate only their cognate G protein subtypes,

dimerization of GLP-1R results in decreased high-affinity binding to its natural ligand, GLP-1, while selectively

analysis restricted to variants impacting gene function Interaction modes of human orexin 2 receptor with selective

Methods & Updates in GPCR Research Development and Characterization of a Highly Selective Turn-On Fluorescent

Screening technologies, structure-informed design, and AI are accelerating target selection.

While some receptors selectively activate specific G protein families, others are more versatile, yielding resonance energy transfer (BRET), and multi-color fluorescence microscopy assays employ conformation-selective

fluorescence chemistry, Celtarys custom-developed ligands offer both high affinity and exceptional selectivity

Chem Rev. 2017 Jan 11;117(1):139-155. Greater specificity : allows for selective tracking of receptor subtypes in complex brain tissues. Chem Rev. 2017 Jan 11;117(1):139-155. doi: 10.1021/acs.chemrev.6b00177 Alavi MS, Shamsizadeh A, Azhdari-Zarmehri