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A., et al. 1997, Bohn, L. M. et al. 1999), while dual knockout is lethal (Schmid, C. L., & Bohn, L.

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.; Bohn, L. M.; Makriyannis, A.; Stevens, R. C.; Liu, Z.-J. J.; Wang, J.; Wu, M.; Katritch, V.; Zhao, S.; Kunos, G.; Bohn, L. M.; Makriyannis, A.; Stevens, R.

composed of seven membrane-spanning α-helices, comprising the transmembrane (TM) domain of the receptor, joined

Later on, Kobilka joined in with Lefkowitz to identify the shared architecture of the β-adrenergic receptor