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postdoctoral training at Boston Children’s Hospital and Harvard Medical School, he joined the lab of Dr Lessons From the Front Lines of Biotech Ajay’s experience in both early-stage biotech and academic science

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postdoctoral training, I joined one of the labs that participated in Latrophilins’ discovery, the lab of Dr

Antonella Di Pizio’s lab , there was almost nothing—no team, no culture, not even proper desks. Over the years you see the lab establishing, and for both of us, of course, growing.”  

New scaffolds modulating the CBRs in both the orthosteric and allosteric sites have been developed, supported Their binding affinity was assessed through radioligand binding, showing a nanomolar affinity for both , both agonists and antagonists. Indeed, the difference is lower than 1pKi value between both experiments. L.; Miljuš, T.; Mexi, M.; Roth, N.; Koers, E. J.; Guba, W.; Alker, A.; Rufer, A. C.; Kusznir, E.

When executed as a unified pipeline, these phases ensure an HCS assay capable of supporting both exploratory Their ability to visualize ligand–receptor interactions directly in living cells produces data that are both Visual + Quantitative Data Fluorescent ligand assays generate both numerical values (IC₅₀, Kᵢ) and spatial Lin S, Schorpp K, Rothenaigner I, Hadian K. Image-based high-content screening in drug discovery.

Studying their dynamics in both a spatial and temporal manner is key to understanding how they work in fluorescent probes must have high specificity, minimal phototoxicity and preferably be compatible with both This is why fluorescent tags, both attached to the protein or to pharmacophores, are so interesting. image stacks, facilitating the reconstruction of GPCR distribution in tissue-like environment , in both

Dr. previously developed to bind Gαs in complex with active GPCRs, enabled detection of GLP-1R activation both

C GPCRs, are obligate dimers, either as homodimers or heterodimers, with distinct conformations in both Recent studies suggest that class B1 GPCRs can form both homodimers and heterodimers, which may play that GLP-1R homodimerization occurs via transmembrane helix 4 (TM4), which forms the interface for both result, dimerized SecR receptors exhibit higher rates of G protein activation and release, improving both

October 2022 "The activity of dopamine neurons is dependent on both intrinsic properties and afferent applications of sub-saturating concentrations of agonists where the co-application of one agonist resulted in both results suggest that the cooperative interaction between G βγ subunits and GIRK channels determines both Coincident activation of D2 and GABAB receptors leads to facilitation of GIRK channel currents, augmenting both

Measuring emission at both donor (usually 620nm) and acceptor (typically 665nm) wavelengths allows for Terbium is compatible with both red and green acceptors. expertise in GPCR biology with advanced fluorescence chemistry, Celtarys custom-developed ligands offer both