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Hi GPCR Fanatics,   This week’s insights will help you avoid wasted time, poor forecasts, and stalled 🔹 Elevate your strategy → Building clarity in GPCR drug discovery Even the strongest GPCR programs GPCR University Learner Dr. GPCR Podcast - Surviving Discovery’s Gauntlet Dr. Listen Now – Real Lessons from a GPCR Expert ➤ The future of GPCR isn’t waiting. GPCR Team Read Full Edition ➤

Keep up-to-date with the latest research and advancements in the field with our convenient, weekly news Methods & Updates in GPCR Research Deep-Learning-Enhanced Diffusion Imaging Assay for Resolving Local-Density Bioinformatics/Data Science at Department of Drug Design and Pharmacology Scientist/Senior Scientist (Research Biochemistry) Speculative Applications (Mass Spectrometry) Speculative Applications (Chemistry) Post-Doctoral Research Assistant Research Fellow - School of Physics and Astronomy Postdoctoral Research Associate (Fixed Term

August 2022 "WELCOME 4GPCRnet meeting bringing together four of the biggest GPCR networks in Europe for Four of the biggest European networks on GPCR research (COST Actions Adher’n Rise and ERNEST plus DFG-funded Read more at the source #DrGPCR #GPCR #IndustryNews

resurgence in recent times for exploratory analyses to identify previously unknown regions critical to GPCR Additionally, deep mutational scanning can generate large-scale datasets, allowing researchers to determine In summary, mutagenesis can be a critical tool in drug discovery, particularly for studying GPCRs. The directed evolution of ligand specificity in a GPCR and the unequal contributions of efficacy and Molecular determinants of ligand efficacy and potency in GPCR signaling.

Matthew T Eddy and his team's research on A2A adenosine receptor activation by G protein and mutations Research Modulating signalling lifetime to optimise a prototypical animal opsin for optogenetic applications drug research Tectonic Therapeutic Announces Start of First Clinical Program for GPCR-Targeted Biologic biomarker expert NEW Postdoctoral Fellow NEW Scientific Assistant Scientist Lead Researcher Post-Doctoral GPCR Ecosystem

GPCR Podcast, we have Dr. Pina Cardarelli, CSO of GPCR Therapeutics. ecosystem.drgpcr.com/dr-gpcr-podcast/ #gpcr#drgpcr #podcast

Hello, hello GPCR Buddies! It's starting to look a lot like Christmas at Dr. GPCR! Dive into a world of knowledge where you can search by topics and events . Classified GPCR News  Let’s dive into the   Classified GPCR News from December 2nd to 8th, 2024 Industry , GPCR Pharmacology Research Associate - Professor Graeme Milligan Postdoc in Molecular Pharmacology Research Structure-guided design of a peripherally restricted chemogenetic system Structural and Molecular

Tom Sakmar didn’t set out to map GPCR-RAMP interactions across hundreds of receptors. , multiplexed platform to investigate GPCR-RAMP biology  like never before. and an online platform to query GPCR-RAMP interaction data and antibody validations. interactions , Family B GPCRs , GPCR scientist network , GPCR data platform , Dr. GPCR ecosystem

October 2022 "G protein-coupled receptors (GPCRs) play critical roles in human physiology and are one endogenous ligands (orthosteric site), allosteric modulators offer new avenues for the regulation of GPCR Recent advances in the structure determination of GPCRs bound to different types of allosteric modulators In this review, we provide a systematic analysis of the currently available GPCR structures in complex Read more at the source #DrGPCR #GPCR #IndustryNews

Watch Episode 167 Today’s GPCR scientists don’t want to study one interaction, they want to model the Compatible with multiple readouts: proximity, immuno assays, pulldowns Validated antibodies + digital search protein interactions  (e.g., 14-3-3) Heterodimerization Endogenous vs. overexpressed systems Orphan GPCR Listen to the complete episode to learn more. _________________ Keyword Cloud : GPCR scientist network , GPCR online course , GPCR data platform , multiplex assays , GPCR drug discovery

research community. Celtarys Research, now partnering with Dr. GPCR, is helping researchers worldwide gain access to customized, reliable assay tools without the delays drug discovery , GPCR research community , medicinal chemistry , Dr. GPCR ecosystem , GPCR online course , GPCR scientist network

September 2022 "Background and purpose: The interaction of arrestins with G-protein coupled receptors (GPCRs GPCRs that internalize without arrestin have been classified as "class A" GPCRs whereas "class B" GPCRs The interaction of arrestins with GPCRs requires both agonist activation and receptor phosphorylation Read more at the source #DrGPCR #GPCR #IndustryNews

Among the different families of G-protein-coupled receptors (GPCRs), adhesion GPCRs (aGPCRs) represent As occurs with other GPCRs in an active state, in aGPCRs the rearrangements induced by the interaction knowing the factors that determine the selectivity of coupling represents a very interesting area of research Barros-Álvarez, X., et al., The tethered peptide activation mechanism of adhesion GPCRs. -Q., et al., Structural basis for the tethered peptide activation of adhesion GPCRs.

This week's highlight includes congrats to: David A Cooper, David Minh, et al., for their research on If you have any research you would like to showcase to our community, you can submit a poster presentation Research Technologies Novo Nordisk Scientist I - Global Research Technologies Novo Nordisk Postdoctoral Associate Research Technologist I Senior Scientist- Internal Medicine Research Unit Postdoctoral Scholar – Synaptic physiology, optical imaging, substance use disorder, pharmacology Research Fellow Postdoctoral

Brian Arey is doing. https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe/ #gpcr #drgpcr #virtualcafe

At Alkermes , Sokhom Pin wasn’t just leading GPCR programs; he was building culture from the ground up When Sokhom joined Alkermes, the company had a strong development arm, but a relatively underdeveloped research In a field like GPCR research (where data complexity and failure rates are high), scientific rigor thrives GPCR ecosystem , GPCR research community , GPCR podcast , GPCR data platform , GPCR training program

regulating the dynamics of the serotonin1A receptor, a crucial neurotransmitter G protein-coupled receptor (GPCR in understanding the modulatory role of the membrane environment on the organization and dynamics of GPCRs Read more at the source #DrGPCR #GPCR #IndustryNews

April 22 - 23, 2024 | Endocrine Metabolic GPCRs Join Dr. GPCR founder Dr. Heptares Operational Highlights and Consolidated Results for 12 Months ended 31 December 2023 Pioneering Research World Congress of Basic and Clinical Pharmacology 2026 GPCR Jobs NEW Research Fellow NEW  Postdoctoral - Single-molecule Imaging Center Scientific Assistant Postdoctoral Fellowship- Mechanistic Biology Research GPCR Ecosystem

and 2 GPCR events! GPCR Partnered Events 3rd GPCRs - Targeted Drug Discovery Summit  Join us at the 3rd GPCRs Targeted Drug Hemicyanine as a "Turn-On" Fluorescence Probe Industry News Domain Therapeutics awarded Hospital-University Research World Congress of Basic and Clinical Pharmacology 2026 GPCR Jobs Post-Doc position Lead Researcher Senior Researcher in Structural Biology Post-Doctoral Fellow Postdoctoral Fellow Research Laboratory Specialist

We’ve curated 10 GPCR papers, seven industry news, and two GPCR job ads! This week's highlight: Dr. GPCR University February 8 - 29: Join Dr. GPCR University's live course with Dr. Terry Kenakin. World Congress of Basic and Clinical Pharmacology 2026 GPCR Jobs NEW Senior Researcher in Structural Biology NEW Post-Doctoral Fellow Postdoctoral Fellow Research Laboratory Specialist Associate Postdoctoral GPCR Ecosystem

While GPCRs can exist as monomers, some types, like class C GPCRs, are obligate dimers, either as homodimers Class B1 GPCRs are an important subclass of GPCRs that include 15 receptors involved in regulating body Research using techniques like bioluminescence resonance energy transfer (BRET) and fluorescence resonance In summary, dimerization in class B1 GPCRs is an emerging area of research that has far-reaching implications for our understanding of GPCR function and signal transduction.

November 2022 "Adhesion G-protein-coupled receptors (aGPCRs) play key roles in a diversity of physiologies A hallmark of aGPCR activation is the removal of the inhibitory GAIN domain and the dipping of the cleaved The structures also reveal the uncharted structural information of GPCR/G12 coupling. Taken together, our study lays the groundwork for understanding aGPCR activation and G-protein-coupling Read more at the source #DrGPCR #GPCR #IndustryNews Subscribe to the Dr. GPCR Newsletter HERE

We will be back next week with our regular weekly GPCR news digest. In the meantime, you can always check the  Classified GPCR News from the last weeks. GPCR Podcast. GPCR. Today is also the first session of our hands-on workshop with Dr. Sam Hoare. GPCR University content coming soon.

Read more at the source #DrGPCR #GPCR #IndustryNews Subscribe to the Newsletter HERE

GPCR podcast with Dr. Nicole (Nicki) Perry-Hauser is now available What a fun chat! GPCR Ecosystem paid membership to enjoy everything Dr. GPCR has! ➡️https://bit.ly/3TCJVQQ #gpcr #drgpcr

Human cells express over 800 G-protein-coupled receptors (GPCRs) to facilitate communication with the complex with the β2-adrenergic receptor (β2AR) at brief sequential intervals following GTP addition, the research This research not only deepens our understanding of a key biological process but also provides a valuable map for pharmaceutical researchers to design new therapies. Time-resolved cryo-EM of G-protein activation by a GPCR. Nature (2024).

network located on intracellular loop 2 that is subject to RNA editing, which differentially affects GPCR Read more at the source #DrGPCR #GPCR #IndustryNews

February 2022 Septerna emerges with $100M to spark 'second golden age' of prolific drug target GPCR with Better known as GPCR, the fruitful research space has led to more than 700 approved drugs over previous The company's co-founder, GPCR pioneer and Nobel laureate Robert Lefkowitz, M.D., has 50 years of experience with the target and analogizes the search for new drugs to oil drilling around the world." Read more at the source #DrGPCR #GPCR #IndustryNews

that the affinity of Fzd for Dvl was not affected by Wnt ligands, in contrast to other members of the GPCR Read more at the source #DrGPCR #GPCR #IndustryNews

GPCR Newsletter! Half Year And Second Quarter Financial Results And Provides Corporate Update Sosei Heptares and Cancer Research , Ion Channels, and Transport Proteins (March 24 - 29, 2024) GPCR Jobs NEW Postdoctoral Fellow NEW Research Laboratory Specialist Associate NEW Postdoc Research Associate Director, Regulatory Affairs Research GPCR Ecosystem