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👉 Most founders look back at the end of the year and try to make sense of the results. The quality of your results is decided early. Why Results Appear Too Late to Change the Outcome 👉 Most teams focus on results because results feel By the time results show up, direction has already been set. Timing shapes results. Early decisions set the direction long before outcomes appear.

(Nasdaq: CRNX), announced that results from the company’s Phase 1 study of CRN04894, the company’s investigational

September 2022 GASP1 enhances malignant phenotypes of breast cancer cells and decreases their response a potential correlation between G-protein-coupled receptor-associated sorting protein 1 (GASP1) and breast However, its biological function and underlying molecular mechanism in breast cancer have not been clearly Here, we demonstrated that GASP1 was highly expressed in breast cancers, and patients harboring altered Functional studies showed that GASP1 knockout significantly suppressed malignant properties of breast

novel medicines for patients with central nervous system (CNS) disorders, today reported its financial results

September 2022 High GPER expression in triple-negative breast cancer is linked to pro-metastatic pathways and predicts poor patient outcomes "Triple-negative breast cancer (TNBC) is a particularly aggressive It is generally considered that TNBC is an estrogen-independent breast cancer, while a new estrogen receptor These results may supply new insights into GPER-mediated estrogen carcinogenesis in TNBC, thus providing

September 2022 Lack of Oestrogen Receptor Expression in Breast Cancer Cells Does Not Correlate with Kisspeptin However, controversy remains regarding its role in breast cancer since both pro- and anti-metastatic In KISS1R overexpressing triple-negative breast cancer (TNBC) cells, stimulation has been associated further investigation and may enable further stratification of the ability of kisspeptin to influence breast

modulation-based drug discovery and development, today reported its half-year and second quarter financial results

August 2022 Karuna Therapeutics Announces Positive Results from Phase 3 EMERGENT-2 Trial of KarXT in medicines for people living with psychiatric and neurological conditions, today announced positive topline results

February 2022 Read more at the source #DrGPCR #GPCR #IndustryNews

modulation-based drug discovery and development, announced today that it will issue its full-year 2021 financial results

The result? You walk out of the meeting thinking it went well. to guess why it matters, what the application is, and whether it fits. ✅ Start with relevance, not results They’ll smile. Nod. Then pass. 4️⃣ Forgetting to frame the next steps One of the most common gaps?

tumor-associated macrophages in a quantitative systems pharmacology model of immunotherapy in triple-negative breast important roles in drug development for complex diseases such as cancer, including triple-negative breast macrophage heterogeneity in the tumor microenvironment while maintaining its predictive power of the trial results

This week's highlight includes congrats to: Miles Thompson ,   Alexander Hauser ,   Caroline Gorvin , potential as therapeutic agents Industry News Nxera Pharma Operational Highlights and Consolidated Results

Daiichi Sankyo to Discover Novel Medicines for CNS Diseases Addex Reports Full Year 2022 Financial Results Financial Year ended 31 December 2022 Addex Raises $5.0 Million in Equity Financing Testing the limits of SMILES-based deep reinforcement learning Structure Therapeutics Reports Fourth Quarter and Full Year 2022 Financial Results

of GPCRs in autism spectrum disorders GPCRs in Oncology and Immunology Molecular characterization of breast skeletal development and disease Industry News Addex Reports 2023 Half Year And Second Quarter Financial Results diabetes and other serious metabolic diseases X4 Pharmaceuticals Reports Second-Quarter 2023 Financial Results from Chronic Neutropenia Clinical Program Structure Therapeutics Reports Second Quarter 2023 Financial Results

This week's highlight includes congrats to: Miles Thompson , Alexander Hauser , Caroline Gorvin ,   et

which involves alveolar differentiation of mammary epithelial cells (MECs), which is essential for breast Our results demonstrated that THC and CBD reduced cellular viability at concentrations above 30μM and

end, you’ll know how to choose the right test, design experiments with power built in, and validate results right statistical test for means, curves, or linear responses ✅ A framework for validating whether your results mean truly overlaps with accepted values Verify if binding and functional assays deliver consistent results correct statistical test for your data structure Compare curves and lines without guesswork Validate your results With the right methods, you’ll know (not hope) that your results are real, reproducible, and actionable

Watch Episode 169 Leadership in science isn't just about results, it's about people. curiosity without burnout He supported work-life balance while maintaining scientific excellence The result

Miles Thompson, Alexander Hauser, Caroline Gorvin et al. for their research on GPCR gene variants and

Recordings in brain slices have shown that co-activation using saturating concentrations of agonists results The results indicate that a low tonic level of G βγ results in facilitation of GIRK current and a high level of G βγ results in occlusion. The results suggest that the cooperative interaction between G βγ subunits and GIRK channels determines Results demonstrate that the activity of either G protein-coupled receptor system must be considered

scheduled fortnightly meetings where I was required to share an article I had read, present my experimental results Whether positive or negative, controls ensure that your results are reliable and not the product of artifacts One of the best pieces of advice I can give is to analyze your results as you progress.

Non-competitive antagonism  results from slow offset kinetics . competitive antagonism  considered reversible and surmountable, while non-competitive antagonism  often results Misinterpreted mechanisms delay decision-making and weaken downstream results.

The result? Misinterpreted potency. Missed opportunities.

When Binding Increases Instead of Decreases Another trap: paradoxical results. Models as Experimental Guides Models don’t just interpret results. They design experiments. The question was: could crude gp120 supernatant be used instead, without corrupting results? Reliable results at a fraction of the cost.

chemistry and biology How to interpret drug behavior across tissues The truth behind those “confusing” lab results

September 2022 "Activation of the complement pathway results in the production of bioactive C3a, a product In light of these new results, it is imperative that we revisit previous studies regarding the role of C3aR in controlling bacterial infections and analyze these results in the context of both extracellular

What if that result wasn’t telling you the whole story?

By systematically mutating every amino acid in the protein and assessing the resulting phenotype, researchers The result suggested that, in contrast to other proton-sensitive channels and receptors, GPR68 did not the study revealed that the protonation of key residues surrounding an extracellular facing cavity resulted scanning encounters several constraints that affect its broad applicability and the interpretation of its results

Our results show that the short-term diffusion coefficient of the receptor decreases upon cholesterol These results are supported by our recent work and present observations that show polymerization of G-actin Taken together, our results bring out the interdependence of cholesterol and actin cytoskeleton in regulating