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Results found for "Brian K Shoichet"
- Maria’s Travel Blogs: ACSMEDI-EFMC Medicinal Chemistry Frontiers 2025
Brian K. Shoichet, Dr. Luc Van Hijfte and Dr. Wendy Young.
- 🤯Mind-blowing GPCR Scoops! Discover the Latest Breakthroughs! ⦿ Nov 18 - 24, 2024
agonists reveal recognition motifs for the MRGPRD GPCR Chunyu Wang , Yongfeng Liu , Marion Lanier , Brian K Shoichet , Esther Martinborough , Jonathan F Fay , Can Cao , Bryan L Roth , et al. adenocarcinoma, β-blockers and antihistamines: A clinical trial is needed Jillian G Baker , Erica K
- Decoding GPCR Function: The Role of Mutagenesis in Rational Drug Discovery
J., Shoichet, B. K., & Jacobson, K. A. (2010). K., Bouvier, M., & Babu, M. M. (2023). L., Gregory, K. J., White, P. J., Sexton, P. M., Christopoulos, A., & May, L. T. (2016).
- Angiotensin-(1-7) improves cognitive function and reduces inflammation in mice following mild trauma
Angiotensin-(1-7) improves cognitive function and reduces inflammation in mice following mild traumatic brain injury "Traumatic brain injury (TBI) is a leading cause of disability in the US.
- Nanobodies: New Dimensions in GPCR Signaling Research
K., Gellman, S. H., Pautsch, A., Steyaert, J., Weis, W. I., & Kobilka, B. K. (2011). M., Manglik, A., Hu, J., Hu, K., Eitel, K., Hübner, H., Pardon, E., Valant, C., Sexton, P. I., Garcia, K. C., Wess, J., & Kobilka, B. K. (2013). D., Tworak, A., Watanabe, K., Pardon, E., Steyaert, J., Kandori, H., Katayama, K., Kiser, P. D., & Palczewski, K. (2023).
- 📰 GPCR Weekly News, May 13 to 19, 2024
CUB domain of the adhesion GPCR ADGRG6/GPR126 is a key regulator of receptor signaling Jiankun Lyu, Brian Shoichet, Bryan Roth, et al. for their research on AlphaFold2 structures guide prospective ligand discovery
- 📰 GPCR Weekly News, March 11 to 17, 2024
This week's highlight includes congrats to: Makaía M Papasergi-Scott, Peter Gmeiner, Brian K Kobilka, in a High Fat Diet-induced Mouse Model of Obesity GPCRs in Neuroscience Xanthurenic acid: A role in brain
- Hop in the Time Machine with GPCR: Unraveling the Future of Research! ⦿ Nov 24 - Dec 1, 2024
receptor (GPCR) pharmacogenomics Miles D Thompson , David Reiner-Link , Alessandro Berghella , Brinda K a Family A GPCR Jun Xu , Geng Chen , Haoqing Wang , Sheng Cao , Jie Heng , Xavier Deupi , Yang Du , Brian K Kobilka Red and far-red cleavable fluorescent dyes for self-labelling enzyme protein tagging and interrogation
- 📰 GPCR Weekly News, April 8 to 14, 2024
Katharina Grotsch, Bryan L Roth, Valery V Fokin et al. for their research on Virtual Screening of a Frizzleds act as dynamic pharmacological entities Marina Casiraghi, Robert J Lefkowitz, Peter Gmeiner, Brian K Kobilka et al. for their investigation on Molecular insights into G protein coupling specificity at
- From Failed Experiments to Predictive GPCR Models
It wasn’t until his postdoctoral years at UCSF—under Brian Shoichet—that GPCRs entered his scientific
- A robust and Efficient FRET-Based Assay for Cannabinoid Receptor Ligands Discovery.
.; Vemuri, K.; Pu, M.; Qu, L.; Han, G. (3), 750-762.e14. https://doi.org/10.1016/j.cell.2016.10.004 . (5) Li, X.; Hua, T.; Vemuri, K. -H.; Wu, Y.; Wu, L.; Popov, P.; Benchama, O.; Zvonok, N.; Locke, K.; Qu, L.; Han, G. W.; Iyer, M. 382–389. https://doi.org/10.1021/acs.bioconjchem.7b00680 . (13) Gazzi, T.; Brennecke, B.; Atz, K. .; Van Der Wel, T.; Mandhair, H.; Honer, M.; Fingerle, J.; Scheffel, J.; Broichhagen, J.; Gawrisch, K.
- Fluorescence based HTS compatible ligand binding assays for dopamine D3 receptors in baculovirus preparations and live cells
To validate that the developed assay is suitable for measuring the K i of different ligands, competition The Log(IC50) change in time was fitted with equation 3 and k given is the weighted average from 3 D.; Hanada, K.; Pagano, R. E.; Miller, L. J. -J.; Veiksina, S.; Kõlvart, K. R.; Min, M.; Kopanchuk, S.; Rinken, A. C.; Chen, K. H.; Bates, M.; Zhuang, X.
- Conjugation Strategies for Probe Development
K., Das, A. K., Eds.; Elsevier, 2023; Vol. 103, pp 59–103. https://doi.org/10.1016/bs.coac.2023.02.005 .
- How Fast Does a Drug Work?
and mastering drug binding kinetics is essential for pipeline efficiency: How fast a ligand binds (k₁ ) and how long it stays bound (k₂) can alter therapeutic profiles dramatically, even if two candidates
- An overview of the compartmentalized GPCR Signaling: Relevance and Implications
Pharmaceuticals (Basel, Switzerland), 14(5), 439. https://doi.org/10.3390/ph14050439 Chen, K. K., Karnik, S. S., Hunyady, L., Luttrell, L. M., & Lefkowitz, R. J. (2003). C., Götz, K., Sungkaworn, T., Lohse, M. J., & Calebiro, D. (2016). I., & O'Malley, K. L. (2017). A., Sriram, K., Wiley, S.
- Unlocking Cell's Secrets: Spontaneous β-Arrestin-Membrane Preassociation Drives Receptor-Activation
K., Selent, J., Hill, S. J., & Calebiro, D. (2023). M., Kawakami, K., Masureel, M., Maeda, S., Garcia, K. C., von Zastrow, M., Inoue, A., & Kobilka, B. K. (2022). Membrane phosphoinositides regulate GPCR-β-arrestin complex assembly and dynamics.
- Fluorescence Polarization in GPCR Research
assays): Displacement of specific radiolabeled ligands in CHO, HeLa, or HEK-293 cells, expressed as K References Kumar V, Chunchagatta Lakshman PK, Prasad TK, Manjunath K, Bairy S, Vasu AS, Ganavi B, Jasti
- Targeted Drug Design through GPCR Mutagenesis: Insights from β2AR
K., Bouvier, M., & Babu, M. M. (2023). K., Hoppe, N., Huang, X. P., Macdonald, C. B., Mehrota, E., Grimes, P.
- Identification of GPCRs Modulating Flow-induced Signaling Pathways in Vascular Endothelial Cells
Brian Arey is doing. https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe/ #gpcr #drgpcr #virtualcafe
- Embark on a GPCR Adventure: Your Weekly Research Expedition! | Oct 21-27, 2024
article Class B1 GPCR Dimerization: Unveiling Its Role in Receptor Function and Signaling Sonja Peter , Brian
- From DNA day to GPCR genomics
K., Strader, D. J., Benovic, J. L., Dohlman, H. G., Frielle, T., Bolanowski, M. A., Bennett, C. K., Hildebrand, P. W., & Skiniotis, G. (2023).
- 📰 GPCR Weekly News, June 24 to 30, 2024
Bryan Roth and Brian Krumm for their study on Molecular glues as potential GPCR therapeutics Drs.
- GPCR News Flash! Top Updates You Can't-Miss! + University CheatSheet is finally available! ❄ Dec 2 - 8, 2024
Structure-guided design of a peripherally restricted chemogenetic system Hye Jin Kang , Brian E Krumm , Adrien Tassou , Bryan L Roth , et al. 🕶 University CheatSheet is here!
- Ode to GPCRs
won the prize for his discovery that dopamine is a neurotransmitter produced in the basal ganglia, a brain prize awarded for work relevant to GPCR-mediated signaling was the 2012 Nobel Prize in Chemistry to Brian Novak, K. Skepticism surrounds triple Nobel winners. Brian K.
- The Perils and Guardrails of Modifying Signalling Proteins in Bioassays
Practical approaches to evaluating and optimizing brain exposure in early drug discovery. Schlander M, Hernandez-Villafuerte K, Cheng CY, Mestre-Ferrandiz J, Baumann M. Dave K, Gelman H, Thu CT, Guin D, Gruebele M. Kim K, Che T, Panova O, DiBerto JF, Lyu J, Krumm BE, et al. Truong ME, Bilekova S, Choksi SP, Li W, Bugaj LJ, Xu K, et al.
- 📰 GPCR Weekly News, December 4 to 10, 2023
Bryan L Roth study on Illuminating the understudied GPCR-ome Save the dates: February 8 - 29: Dr. Research Transcriptome analysis of Schizothorax oconnori (Cypriniformes: Cyprinidae) oocytes: The role of K+
- 📰 GPCR Weekly News, November 13 to 19, 2023
Brian Krumm and Bryan Roth studied CryoEM structures of adhesion in GPCR CD97, filling gaps.
- VAMP2: a crucial player in the delivery of MOR to the synapse
essential for developing new treatments for these disorders and advancing our understanding of the brain K ´ onigstorfer, M. Mozhayeva, Y. Sara, T.C. Südhof, and ¨ E.T. Kavalali. 2001.
- GPCR/endocytosis/ERK signaling/S2R is involved in the regulation of the internalization...
extracellular signal-regulated kinases 1/2 (ERK1/2) signaling, p38 signaling, mitochondrial respiration and Na+/K+
- GPCR Weekly Whirlwind: Top Receptor Highlights from Sep 30 - Oct 6, 2024!
fantastic paper on Development of Putative Bivalent Dicovalent Ligands for the Adenosine A1 Receptor Bryan Roth and Brian Krumm for their excellent study on Molecular glues as potential GPCR therapeutics Sabrina



















