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December 2021 OMass Therapeutics's founder, Carol Robinson, has been awarded the prestigious Louis-Jeantet Benjamin Franklin Medal in Chemistry from The Franklin Institute "Huge congratulations to our founder, Carol

Kathleen M Caron and her team studied the GPER/GPR30 complex with β1-adrenergic receptor and AKAP5 in

Canonical chemokine receptors – scavenging “decoys” Chemokine receptors coordinate cell migration upon The chemokine receptor family comprises 19 canonical chemokine receptors together with 4 atypical chemokine Although less characterized, canonical chemokine receptor systems have been also shown to not only directly CCR2 canonical signaling requires the activation of Gαiβγ, followed by phosphorylation of the receptor But why do canonical chemokine receptors have this dual role in physiology?

More specifically, this review covers assays to monitor the canonical G protein signaling pathway (e.g recruitment/activation, inositol phosphate accumulation, or Ca2+ mobilization), assays to monitor non-canonical

GPCRs, Ion Channels, and Transport Proteins (March 24 - 29, 2024) GPCR Jobs NEW Postdoctoral Fellow, Caron

October 2022 "G protein-coupled receptors (GPCRs) are important drug targets characterized by a canonical

Senior Scientist- Membrane Technologies NEW Computational Protein Design (GPCR) Postdoctoral Fellow, Caron

December 2021 "Dame Carol Robinson DBE, FRS, FRSC, FMedSci, Oxford University’s first female Professor

Surgery Senior Scientist- Membrane Technologies Computational Protein Design (GPCR) Postdoctoral Fellow, Caron

October 2022 "The canonical model for G protein-coupled receptors (GPCRs) activation assumes that stimulation

Here, we determine that GRKs phosphorylate a non-canonical substrate, anterior pharynx-defective 1A (

., Caron, M. G., Lefkowitz, R. J., & Strader, C. D. (1986).

various cellular processes such as cell proliferation, migration, apoptosis, and transcription via canonical

Aaron Sato, Chief Scientific Officer at Twist Bioscience, elaborates.

various cellular processes such as cell proliferation, migration, apoptosis, and transcription via canonical

7TM-independent functions of Latrophilins are essential for neuronal physiology, possibly complementing canonical

All CKRs studied show the canonical active conformation, except CX3CR1 which displays a significantly As a result of the unique active conformation, the residues in the microswitch network show non-canonical The Non-canonical Toggle Switch 6.48 - CCR6 as a model CKR The structure of CCR6 bound to CCL20 reveals the "toggle switch" position 6.48 and the disruption of a hydrogen-bond network surrounding this non-canonical

highly-conserved GPCR-autoproteolysis-inducing (GAIN) domain, the latter of which is located immediately before a canonical

Targeting GRK2 and GRK5 for treating chronic degenerative diseases: Advances and future perspectives Non-canonical

effectors along the Gαq/Phospholipase C (PLC) pathway, which results in an IkB kinases (IKK)-mediated canonical

pharmacology' Yao Lu and colleagues work on 'Molecular insights into orphan GPCRs relevant to schizophrenia' Carole

Industry News Professor Dame Carol Robinson Received 2023 ASMS John.B.Fenn Award Exscientia Announces

Carbon dioxide-induced decrease in extracellular pH enhances the production of extracellular matrix components

Small-molecule targeting of GPCR-independent non-canonical G protein signaling inhibits cancer progression

Leukotriene B4 receptor 2 governs macrophage migration during tissue inflammation From odor to oncology: non-canonical