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Numerous intracellular mediators are activated by these G protein-coupled receptors based on several

August 2022 "Emerging evidence suggests that G protein-coupled receptor (GPCR) kinases (GRKs) are associated

Rho1 signaling is activated by G-protein-coupled receptor (GPCR) signaling at the cell surface.

Therapeutics, a biopharmaceutical company specializing in the discovery and development of new drugs targeting G

Rho1 signaling is activated by G-protein-coupled receptor (GPCR) signaling at the cell surface.

September 2022 "Given the promising clinical value of allosteric modulators of G protein-coupled-receptors

September 2022 "Class A (rhodopsin-like) G protein-coupled receptors (GPCRs) are constitutive phospholipid

PTH-related peptide (PTHrP) bind to the parathyroid hormone receptor 1 (PTH1R) and activate the stimulatory G-protein

They are G-protein-coupled receptors and bind as ligand retinal, which is bound covalently to a lysine

Cannabinoid CB1 Receptor Bound to a Negative Allosteric Modulator, ORG27569, and Analogs "A growing number of G-protein-coupled

Gq Signaling Cryo-EM structures of Gq-bound PTH1R uncover glycan and loop-based mechanisms shaping G-protein

. 30, 2021 -- Orion Biotechnology, a clinical stage company unlocking the therapeutic potential of G

August 2022 "Fluorescently labeled ligands are versatile molecular tools to study G protein-coupled receptors

August 2022 "G-protein-coupled receptors (GPCR) are present at the cell surface in different conformational

Biotechnology Canada Ltd, a drug discovery and development company unlocking the therapeutic potential of G

A major pan-receptor focus has been to identify GPCR-selective ligands that have bias in G protein-dependent

The targets, including G protein-coupled receptors (GPCRs), intracellular protein complexes and solute

gives me great pleasure to announce the fourth hybrid symposium on regulatory autoantibodies targeting G-protein-coupled

Hexahydroquinoline Derivatives are Selective Agonists for the Adhesion G Protein-Coupled Receptor ADGRG1 The G protein-coupled receptor neuropeptide receptor-15 modulates larval development via the transforming

platform, which uses conformationally selective VHH antibodies – ConfoBodies® – to stabilize GPCRs (G

to 20, 2023 Adhesion GPCRs Amelioration of non-alcoholic fatty liver disease by targeting adhesion G that a glucagon-bound extracellular domain of the glucagon receptor is dynamic Ligand recognition and G

Enabling the Design of Nucleoside Functional Switches for the A2A Adenosine Receptor "Modulators of the G

regulation of gluconeogenic gene transcription is endocytosis-dependent in primary hepatocytes "A number of G

Here, we discovered that the epithelial-cell-derived antimicrobial peptides defensins activated orphan G-protein-coupled

meningitidis and identified 30 N-acyl amides with representative members serving as agonists of the G-protein

October 2022 "The very large G protein-coupled receptor (VLGR1, ADGRV1) is the largest member of the

recruitment, activation, and scaffolding of numerous cytoplasmic signaling complexes and assist in G-protein

coupling to the same GPCR in living cells "β-arrestins mediate regulatory processes for over 800 different G

Opioid receptors are G-protein-coupled receptors (GPCRs) part of cell signaling paths of direct interest

non-nutritive sweetener sucralose increases β-arrestin signaling at the constitutively active orphan G complex neuroendocrine regulatory networks mediated by spinal cord injury-induced immunodeficiency G