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A GPCR Internalization Tool Designed for Real Research Needs Built on more than two decade A GPCR Internalization Tool Designed for Real Research Needs s of GPCR assay innovation , pHSense™  was developed to overcome

Fluorescence Polarization (FP) is especially useful since it allows real time detection and there is no need This means no washing steps are needed to reduce background signal. Figure 1. Unlike other techniques (FRET-based), only one fluorophore is needed.

week: high-impact insight into GPCR allostery, crafted for pharmacologists and biotech scientists who need Why you need to be there: Learn how kinetic nuance shapes ligand design.   GPCR scientists, translational pharmacologists, biotech drug discovery teams, and decision-makers who need

The excitement I felt when I first attended back in Boston is the same one I feel now that I am the organizer historically excluded demographics are finally included, this represents a building block to reinforce the need Mariachi song: I typically do not sing to these since they are dear to Mexican childhood memories, and I feel

technical overview, this is a story of curiosity, persistence, and using science to meet unmet clinical needs publish or patent; it was to bring a novel, safer class of pain therapeutics to patients — an urgent need Whether it's chronic pain, addiction, or another unmet need, keeping the real-world impact in focus can

First responders describe revivals that don’t feel like revivals, as if the body is still trapped in those pathways, her research gives scientists, first responders, and policymakers the knowledge they need

Traditional roles rarely gave me the freedom to implement these changes at the scale needed. conversations keep me on the front lines, sharpening my understanding of the common bottlenecks and evolving needs

Other times, you’ll need to sprint. Knowing the difference is survival.

, and system sensitivity to surface mechanism—before you lock in a screen that hides the signal you need translational pharmacologists, biotech discovery teams, platform company leaders, and decision-makers who need ’s breakthroughs—and avoid delays others won’t see coming. 👉 Don’t Fall Behind—Access the Edge You Need

incorporating kinetic modeling early in your pipeline, ensuring your candidates have the persistence needed GPCR scientists, translational pharmacologists, biotech discovery teams, and decision-makers who need ’s breakthroughs—and avoid delays others won’t see coming. 👉 Don’t Fall Behind—Access the Edge You Need

Building for the Future The Sakmar lab built a system to meet that need: Dual-epitope tagged constructs

GPCR scientists, translational pharmacologists, biotech drug discovery teams, and decision-makers who need Don’t Fall Behind—Access the Edge You Need 👉 Access all the news and upcoming events ➤ 👉 Already a To succeed, you need to move beyond standard approaches and adopt the frameworks that are driving real

a disease where novel interventions that move beyond dopamine receptor antagonists are desperately needed While more work is needed to further elucidate the translational value of selectively targeting CB2 receptors

This emphasis may have caused other signaling pathways to be overlooked due to a need for adequate assay aberrant ERK activity can lead to uncontrolled cell proliferation and survival​, highlighting the pressing need This further underscores the need for advanced assay technologies and a deep understanding of cellular

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continuously migrate by remaining responsive to chemokines, it dampens the inflammatory response when needed implications of its inhibition, an in-depth understanding of the underlying regulatory mechanisms is needed

GPCR scientists, translational pharmacologists, biotech discovery teams, and decision-makers who need ’s breakthroughs—and avoid delays others won’t see coming. 👉 Don’t Fall Behind—Access the Edge You Need

classic models of Schild and Gaddum  continue to inform modern analysis, while also highlighting the need topics Who it’s for:  drug discovery teams, pharmacologists refining their toolkit, and scientists who need

phosphorylation barcodes shape arrestin engagement, a biased NTSR1 modulator targets pain without the need

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It’s a system-aware resource built for researchers who need clarity fast—reinforcing system-level GPCR Don’t Fall Behind—Access the Edge You Need Already a Premium Member?

GPCR scientists, translational pharmacologists, biotech discovery teams, and decision-makers who need Kenakin… sorely needed in the field." — DrGPCR University Attendee 🚀 Join now — and learn to design

GPCR the best for the sake of promoting more educational opportunities that are sorely needed in the

November 2021 "Target class-specific libraries mean you need to screen less to identify high-quality protein-coupled receptors (GPCRs), more libraries, including better and more targeted libraries, are needed

GPCR scientists, translational pharmacologists, discovery teams, and decision-makers who need fast, curated GPCR the best for the sake of promoting more educational opportunities that are sorely needed in the

It’s a story of leadership, scientific rigor, and tools built for the needs of modern discovery teams

first-in-class small molecule agonists for a challenging orphan GPCR for a highly relevant therapeutic need

To understand how incretin receptors behave in intact tissue, Hodson needed people who saw problems differently You need genetics teams for variant interpretation, metabolic phenotyping facilities for in vivo work

scientific perspective is broad, and we are happy to consider any research proposals from those in need

GLP-2 system in the gut and the bones, potent and selective GLP-2 receptor (GLP-2R) antagonists are needed