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University courses in the next 12 months -  Only applicable to individual registrations This course will take Take advantage of the early bird registration until April 18th, 2024, to save 25%! Please complete this form to take advantage of this opportunity. If you want to showcase your research, you can submit a poster presentation to our community, take advantage Preassembly of specific Gβγ subunits at GABAB receptors through auxiliary KCTD proteins accelerates channel gating

Attrition rates in early pharmacology remain painfully high. And the rate of attrition in these steps is still atrocious.” A smart program doesn’t wait until late stages to validate its assumptions.

In liposomes, opsin scrambles lipids at a unitary rate of >100,000 per second. Expected final online publication date for the Annual Review of Biophysics, Volume 51 is May 2022.

Onset and offset rates (not just “final numbers”) decide which drugs succeed in patients and which ones , using rapid calcium assays Potency Is a Ratio of Rates Two ligands compete for the same receptor. You calculate an equilibrium value that requires a physically impossible onset rate. it around, and you’ve got a shortcut: use depression of max in calcium assays to rapidly rank offset rates truly equilibrated Detect hidden activities before they waste resources Classify antagonists by offset rate

But because the program is run on duct tape and heroics instead of precision. Ambiguous Decision Gates: Molecules advance or stall based on vibes, not criteria.

Announcements Please save the date for the 2024 aGPCR workshop hosted by Antony Boucard! This exciting conference will take place from October 23-25th. We'll see you in Mexico City! Also, seeing the expanding diversity among the aGPCR community, added to the fact that this will all take experience: The Day of the Dead celebrations: This happens over the weekend during the end of October and takes of your lungs while executing your best perreo or Luis Enrique’s “Yo no sé mañana” while a stranger takes

You’re stating your purpose without hedging, signaling awareness of the other person’s expertise, and Building a Scientific Career Through Asking Better Questions in Science Late in the conversation, JB

Bryan L Roth study on Illuminating the understudied GPCR-ome Save the dates: February 8 - 29: Dr. | 3rd GPCRs - Targeted Drug Discovery Summit March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 1 - 4, 2024 |

Instead of dreading lab time, she found herself chasing questions late into the night. Not from polished plans—but from patterns of curiosity, risk-taking, and mentorship loops.

Save the dates: September 7 - 8: Join the 3rd ECI GPCR Symposium, an event by and for early career investigators International Conference and Exhibition NEW March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar NEW March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference NEW April 5 - 10

Save the date: TOMORROW - November 17: Don't miss out on our final Dr. | 3rd GPCRs - Targeted Drug Discovery Summit March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference NEW April 1 - 4, 2024

protein activation in cells occurs in less than a second, reflecting the transient nature of these active states affinity for GTP, allowing a detailed observation of its interaction with the Gs protein in its activated state The activation process begins with the α-helical domain (AHD) of the G protein in an open state, which This detailed process provided by the cryo-EM study offers a clear view of these dynamic states, from an inactive state (open AHD and GTP unbound) to an active state (closed AHD and GTP bound) and ultimately

Save the dates: November 2 - 4: We are excited to announce that we are sponsors of the GPCR Retreat and SLAS2024 International Conference and Exhibition March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 5 - 10, 2024

Please take a look at the weekly Classified GPCR News from September 11th to 17th, 2023. SLAS2024 International Conference and Exhibition March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 5 - 10, 2024

Save these dates: September 22: Join us for the Dr. SLAS2024 International Conference and Exhibition March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 5 - 10, 2024

Mark your calendars for these important events: September 22: Save the date for the Dr. SLAS2024 International Conference and Exhibition March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 5 - 10, 2024

complex Deep Learning Dynamic Allostery of G-Protein-Coupled Receptors Industry News Sosei Heptares to take | 3rd GPCRs - Targeted Drug Discovery Summit March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 1 - 4, 2024 |

Take a few minutes, and dive into our GPCR coverage! We welcome GPCR paper suggestions! | 3rd GPCRs - Targeted Drug Discovery Summit March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 1 - 4, 2024 |

The Quiet Drift You Don’t Feel Until It’s Too Late 👉 Every early-stage biotech reaches a moment where They’re cadence gaps. 👉 A strong cadence is simple: Monthly CEO strategic alignment note Quarterly “state

responses by forming complex with Neurokinin-1 receptor NTR-1's Essential Contribution to Asymmetric Mating | 3rd GPCRs - Targeted Drug Discovery Summit March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 1 - 4, 2024 |

Instead of just staying up to date, dive in, broaden your knowledge, and pave the way in the fantastic Take Action Now and Join our Community of Learners! Let's take your brand to the next level together!

  — A tale of detergent tails: GPCR activation beyond ligands .   A structural cautionary tale for all of us.  Want the full breakdown?

Enzyme Behavior: The Nonlinear Gatekeeper In GPCR programs, CYP interactions often appear late—usually too late. Interrogate agonists across multiple receptor-expression states.

Kenakin from Terry's Corner shows how to tame irreversible drugs so their kinetic power works for you Designing for penetration —balance on/off rates to reach inner tissue, not just peripheries.

Take 2 minutes to fill out this survey and let us know what you liked, what you didn’t, and what we can March 13 - 15 | 9th German Pharm-Tox Summit March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 1 - 4, 2024 |

It was the first time late nights in the lab weren’t a burden but a sign of genuine engagement. s Next in Her Opioid Research Catherine’s current experiments focus on outcomes such as respiratory rate

their team's work on Molecular determinants of ligand efficacy and potency in GPCR signaling Save the date | 3rd GPCRs - Targeted Drug Discovery Summit March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 1 - 4, 2024 |

Docking 490 million molecules against the σ2 receptor's AF2 model yielded a 54% hit rate, comparable to the 51% hit rate using the crystal structure. models showed some variations at key residues, and docking 1.6 billion molecules resulted in high hit rates Of 161 molecules tested, 42 substituted more than 50% of [³H]-LSD at 10 μM, achieving a 26% hit rate.

👋 Take a look at the latest and greatest in GPCR research. Save the date! Dr. GPCR Symposium on GPCR Activation and Signaling, May 19th, 2023.

Tagged for arrest: 'Barcode' determines receptor's fate. Our next Dr. We would also like to take a moment to thank the organizers for inviting Dr. Therapeutics to Present at Jefferies Healthcare Conference Tagged for arrest: “Barcode” determines receptor’s fate