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stem cell loss Activation of Polycystin-1 Signaling by Binding of Stalk-derived Peptide Agonists GPCR Binders

ATP via P2X4 receptor] Osmotic stress studies of G-protein-coupled receptor rhodopsin activation GPCR Binders

Role of protease activated receptor 4 (PAR4) in mouse models of acute and chronic kidney injury GPCR Binders

linked to X-linked acrogigantism The mechanism of Gαq regulation of PLCβ3-catalyzed PIP2 hydrolysis GPCR Binders

Mutations in target proteins can lead to decreased drug affinity and/or potency, rendering treatments

GPCR Binders, Drugs, and more Allosteric modulation of a human odorant receptor.

agonist-driven regulation of the neurokinin 1 receptor using a GPCR phosphorylation immunoassay GPCR Binders

Signaling Subcellular activation of β-adrenergic receptors using a spatially restricted antagonist GPCR Binders

Impact of membrane lipid polyunsaturation on dopamine D2 receptor ligand binding and signaling GPCR Binders

allostery, can effectively measure the strength of an allosteric effect as agonist's efficacy GPCR Binders

families in human and Drosophila Functional diversification of cell signaling by GPCR localization GPCR Binders

anaphylatoxins: unveiling the molecular mechanisms of complement receptor activation and signaling GPCR Binders

sense noxious heat via Gαq signaling Exploring the Activation Mechanism of the GPR183 Receptor GPCR Binders

Extremely strong binders can fail in structured tissues because they saturate the periphery and never

Snapshot of the cannabinoid receptor 1-arrestin complex unravels the biased signaling mechanism GPCR Binders

calcineurin pro-survival pathway and confers chemoresistance by mediating glucose metabolic symbiosis GPCR Binders

Bryan Roth's work on "Built-in functional selectivity in neurons is mediated by the neuronal protein,

GPCR Binders, Drugs, and more Engineered Human Antibody with Improved Endothelin Receptor Type A Binding

Read the complete article here: https://www.ecosystem.drgpcr.com/gpcr-binders-drugs-and-more/in-depth-molecular-profiling-of-an-intronic-gnao1

responses to GPCR agonists for exploration of GLP-1R ligand effects in pancreatic β-cells and neurons GPCR Binders

GPCR Binders, Drugs, and more Predicting allosteric sites using fast conformational sampling as guided

protein-coupled receptors supports the independent expansion of bilaterian and cnidarian peptidergic systems GPCR Binders

essential for developing new treatments for these disorders and advancing our understanding of the brain

History and function of the lactate receptor GPR81/HCAR1 in the brain: a putative therapeutic target

GPCRs in Neuroscience Physiological Condition Dependent Changes in Ciliary GPCR Localization in the Brain

members of the RGS family are selective for certain GPCRs, as a proof RGS4 which is expressed in the brain

Opioid Receptor-Mediated Regulation of Neurotransmission in the Brain.

Subtype specificity:  selectively track receptor subtypes in complex brain tissue.

protein intake setpoint in Drosophila Kappa Opioid Receptor Activation Induces Epigenetic Silencing of Brain-Derived

Practical approaches to evaluating and optimizing brain exposure in early drug discovery. serotonin 5-HT2A receptor inverse agonism for Gαi1- and neutral antagonism for Gαq/11-proteins in human brain