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Results found for "Umut Onur Özcan"
- 📰 GPCR Weekly News, October 16 to 22, 2023
November 17: Join our last Dr. GPCR Symposium of the year on GPCRs in Immunology and Oncology! Our confirmed speakers are Dr. Xavier Leroy, Dr. Brian Arey, and Dr. J. Silvio Gutkind.
- Multifunctional role of GPCR signaling in epithelial tube formation
Our data support a model wherein Smog regulates distinct myosin pools and actin cytoskeleton in a ligand-dependent
- Molecular mechanism of allosteric modulation for the cannabinoid receptor CB1
Our findings fill a gap in the understanding of CB1 allosteric regulation and could guide the rational
- Location bias contributes to functionally selective responses of biased CXCR3 agonists
Our work demonstrates that differential subcellular signaling is critical to the overall biased response
- The Gluopsins: Opsins without the Retinal Binding Lysine
Our final opsin phylogeny is the largest to date with 4956 opsins.
- Allosteric modulation of GPCRs: From structural insights to in silico drug discovery
allosteric modulators have led to the identification of multiple allosteric sites and significantly enhanced our
- Membrane Lipids Are an Integral Part of Transmembrane Allosteric Sites in GPCRs: A Case Study of...
Our results demonstrate the significance of incorporating membrane lipids as an integral component of
- Chronic itch: emerging treatments following new research concepts
Current progress in our knowledge of the itch processing, the numerous mediators and receptors involved
- Fluorescent Ligands Targeting Intracellular Allosteric Binding Site of the Chemokine Receptor CCR2
Thus, our small-molecule-based fluorescent CCR2 ligand 14 represents a promising tool for future studies
- Tracking receptor motions at the plasma membrane reveals distinct effects of ligands on CCR5...
Applied to HIV-1 envelope glycoproteins gp120, our quantitative analysis revealed agonist-like properties
- 📰 GPCR Weekly News, January 23 to 29, 2023
Hello Readers👋, We're excited to share our weekly newsletter with you. Keep up-to-date with the latest research and advancements in the field with our convenient, weekly news
- 📰 GPCR Weekly News, January 16 to 22, 2023
Hello Readers👋, We're excited to share our weekly newsletter with you. Keep up-to-date with the latest research and advancements in the field with our convenient, weekly news
- Decoding GPCR Function: The Role of Mutagenesis in Rational Drug Discovery
bioinformatics and machine learning will play a pivotal role in addressing these obstacles, enhancing our structural biology techniques like X-ray crystallography and cryo-electron microscopy have deepened our
- 📰 GPCR Weekly News - January 9 to 15, 2023
Hello Readers👋, We're excited to share our weekly newsletter with you. Keep up-to-date with the latest research and advancements in the field with our convenient, weekly news
- 📰 GPCR Weekly News, August 14 to 20, 2023
Our poster session is now a discussion on Kumospace. The GPCR Retreat is coming up November 2-4! Stay updated with our monthly Dr. GPCR Newsletter!
- Structural perspectives on the mechanism of signal activation, ligand selectivity and allosteric...
and allosteric modulation in angiotensin receptors: IUPHAR Review 34 "Functional advances have guided our
- The Adhesion GPCR VLGR1/ADGRV1 Regulates the Ca2+ Homeostasis at Mitochondria-Associated ER Membrane
Our data demonstrate the molecular and functional interaction of VLGR1 with components in MAMs and point
- Dr. GPCR Spotlights Revvity’s pHSense™ Internalization Tools
Through our podcast, training programs, and partner content, we help scientists connect, collaborate,
- 📰 GPCR Weekly News, July 24 to July 30, 2023
Then, join us on September 22nd for our discussion session, formerly known as The poster session, on We'll be sharing the list of our confirmed speakers soon!
- Unlocking the Future of Medicine: Advancements in GPCR Research
We are pleased to announce the scheduled dates for our highly anticipated courses led by Dr. As of July 31st, early-bird registration for our premium Ecosystem members will begin, allowing you to
- Functional modulation of PTH1R activation and signaling by RAMP2
Employing homology modeling, we describe the putative structural molecular basis underlying our functional
- Dynamics of tumor-associated macrophages in a quantitative systems pharmacology model of...
contributors to the immuno-suppressive tumor microenvironment, we incorporated the dynamics of TAMs into our
- 📰 GPCR Weekly News, September 11 to 17, 2023
Check out our GPCR roundup now, and be the first to read! This week's highlights: Celebrating Dr. Kevin Wright on his new position as Director of Targeted and Immuno-oncology at GPCR Therapeutics, our
- Case Report of a Juvenile Patient with Autism Spectrum Disorder with a Novel Combination of Copy...
To our knowledge, this is the first report of a CNV in the ADGRL3 gene and its first association with
- 📰 GPCR Weekly News, September 4 to 10, 2023
Welcome to our latest GPCR updates. This week's highlights: Dr. Our partner, Domain Therapeutics, will attend the SACHS 23rd annual biotech event in Europe. Dr.
- 📰 GPCR Weekly News, August 28 to September 3, 2023
Stay informed with our GPCR roundup. Our poster session is now an engaging Kumospace discussion.
- In vivo detection of GPCR-dependent signaling using fiber photometry and FRET-based biosensors
Our approach, described in detail here, uses adeno-associated viruses infused intracerebrally in order
- 📰 GPCR Weekly News, January 8 to 14, 2024
Dive into our GPCR coverage for this week! GPCR Ecosystem contents and perks, including our forums, private groups, and all Ecosystem members Only
- 📰 GPCR Weekly News, January 1 to 7, 2024
GPCR Ecosystem contents and perks, including our forums, private groups, and all Ecosystem members Go Global Rights to Oral MC4R Agonist LB54640 Addex to Present at Biotech Showcase™ 2024 Establishing our
- Structural basis for receptor selectivity and inverse agonism in S1P5 receptors
Together with previously published S1PR structures in complex with antagonists and agonists, our structure



