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Hello GPCR Community, Stay up-to-date with the latest GPCR research, including breakthrough studies, top researchers to explore the latest advances in designing precise GPCR-targeted drugs, including the Research Services Agreement with Pfizer on Targeted Protein Degradation Modalities A quick revision July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology GPCR Jobs HIGHLIGHT Research mechanosensing   Postdoctoral Position Postdoctoral research position Senior or Lead Researcher   GPCR

Hello GPCR Trailblazers, This week, we’re spotlighting Celtarys Research, our newest partner, featured GPCR will help researchers move faster with custom fluorescent ligands, translational insight, and tool-enabled Introducing Celtarys - Probe Development via Conjugation Strategies   Celtarys Research's first article Explore this week’s research, tools, and biotech insights in one place. The insights are ready. GPCR Team

GPCR signaling almost never follows a straight path. This article is about one big idea: GPCRs don’t act in isolation—they respond to the system they’re in In this session, you’ll gain: ✅ A mental model you can trust  for predicting how GPCR ligands behave Internalized Signaling: Same Receptor, Different Story A GPCR response isn’t always over when the receptor Constitutive Activity: When Doing Nothing Still Does Something Some GPCRs simply refuse to stay quiet

GPCR Summit 2022 held between Oct. 10 - 16, it's FREE! Join the #GPCR movement by signing up now! ➡️ https://bit.ly/3cKMXlw #gpcr #drgpcr

Hey there, fellow GPCR enthusiasts! Let's gather 'round for our weekly dose of GPCR News. Methods & Updates in GPCR Research GPCRana: A web server for quantitative analysis of GPCR structures - 29, 2024) GPCR Jobs NEW Research Scientist/Senior Scientist I - Molecular Pharmacology NEW Vice President Scientist II DOE (Native Mass Spectrometry) Senior Vice President of Global Medical Affairs Postdoctoral Research GPCR Ecosystem

October 2022 Regulation of pulmonary surfactant by the adhesion GPCR GPR116/ADGRF5 requires a tethered activation mechanism "The mechanistic details of the tethered agonist mode of activation for the adhesion GPCR Read more at the source #DrGPCR #GPCR #IndustryNews

But what are the conformation changes that drive GPCR dimerization? How dynamic are GPCRs dimer interfaces? GPCRs constantly bind to form dimers and dissociate to form monomers. But how can we target GPCR dimers? via%3Dihub #GPCR #DrGPCR#Ecosystem

Hey there, GPCR Enthusiasts! Are you geared up for your GPCR fix of the day? pharmacology for practical application in both academic and industrial research settings. HIGHLIGHT Research Associate - Professor Graeme Milligan HIGHLIGHT Postdoc in Molecular Pharmacology mechanosensing   Postdoctoral Position Postdoctoral research position GPCR Activation and Signaling Research Protocol for detecting endogenous GPCR activity in primary cell cultures using ONE-GO biosensors

GPCR news content, make sure to subscribe to our monthly newsletter for Dr. GPCR News. Methods & Updates in GPCR Research GPCRLigNet: rapid screening for GPCR active ligands using machine Papers GPCRs: Signal Transduction. Bioinformatics/Data Science at Department of Drug Design and Pharmacology Scientist/Senior Scientist (Research GPCR Ecosystem

Hello GPCR Enthusiasts, Dive into this week's exciting updates on cutting-edge GPCR research, new learning Receptors for New Therapeutic Options 📍  Boston, MA 📅 October 2 -3, 2024 Join top researchers to explore Papers Emerging Voices in GPCR Biology in Special Issue of Molecular Pharmacology GPCR Events, Meetings Congress of Basic and Clinical Pharmacology GPCR Jobs HIGHLIGHT Research Associate - Professor Graeme mechanosensing   Postdoctoral Position Postdoctoral research position Adhesion GPCRs The N terminus-only

GPCR Summit is totally FREE for our Ecosystem site members? ➡️ https://www.ecosystem.drgpcr.com/ #gpcr #drgpcr

We found that some agonist-induced GPCR/14-3-3 signal intensities can rapidly decrease. could also be paralleled with GPCR/β-arrestin-2 signals, indicating diminished levels of GPCR/signal Furthermore, we found that certain GPCR ligands can regulate GPCR/14-3-3 signals temporally, suggesting a new approach for GPCR drug development by modulating GPCR/14-3-3 signals temporally." Read more at the source #DrGPCR #GPCR #IndustryNews

DrGPCR Ecosystem membership or listen wherever you get your podcast for free ➡️https://bit.ly/3UdxgnR #gpcr

Traditionally, GPCR signaling was believed to primarily occur at the plasma membrane. GPCRs have also been identified within the mitochondria. Compartmentalized GPCR Signaling from Intracellular Membranes. Functional selectivity of GPCR-directed drug action through location bias. Neurochemical research, 42(1), 166–172. https://doi.org/10.1007/s11064-016-2026-6 Mendizabal-Zubiaga,

His work spans deep academic research, startup life, and the application of machine learning and pharmacology There, Ajay expanded his understanding of neurobiology and translational research models, further refining He emphasizes that building a startup is not simply a continuation of research — it requires a mindset Advice for Young Scientists For early-career researchers, Ajay’s journey offers a powerful blueprint. addiction, or another unmet need, keeping the real-world impact in focus can clarify career decisions and research

In 2007 he formed IndiPharm which was a full-service Contract Research Organization whose operational #biotech #lifesciences #appointment #GPCR #Oncology" Read more at the source #DrGPCR #GPCR #IndustryNews

Biosensors for monitoring G protein-coupled receptors (GPCRs), the most drugged class of proteins in Read more at the source #DrGPCR #GPCR #IndustryNews Subscribe to the Newsletter HERE

Hello Readers👋, GPCR weekly newsletter is here! GPCR Symposium event held on March 24th. GPCRs in Neuroscience Physiological Condition Dependent Changes in Ciliary GPCR Localization in the Brain Methods & Updates in GPCR Research Time- and cost-efficient bacterial expression and purification of GPCR Ecosystem

in Sapap3 knockout mice Methods & Updates in GPCR Research Genome-wide identification of 769 G protein-coupled Project Ambrosia lands $16m to ‘improve on existing GLP-1 drugs’ Opening Ceremony of Xuzhou Zhongshu Research July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology GPCR Jobs NEW Research Associate Postdoc in GPCR mechanosensing   Postdoctoral Position Postdoctoral research position Senior or Lead Researcher   Become a Premium Member!

G protein-coupled receptors (GPCRs) are a vast family of membrane-bound proteins crucial for transmitting 'unproductive coupling'[1] and a fascinating phenomenon known as GPCR priming [2]. The enhanced signalling observed in GPCR priming is attributed to the formation of temporal non-cognate-GPCR GPCR priming opens new avenues for understanding the nuanced regulatory mechanisms governing GPCR signalling In conclusion, GPCR priming represents a compelling area of research that promises to deepen our understanding

Hi GPCR Enthusiasts (and Arrestin Aficionados!)   This week at Dr. GPCR, we’re decoding arrestin-driven signaling and spotlighting the tools to match.   of GPCR-RAMP discovery. GPCR Updates   Advanced Methods for the Optimization of Candidate Selection  – Master GPCR behavior beyond Explore this week’s research, tools, and biotech insights in one place.

cooperative interaction between G βγ subunits and GIRK channels determines both the amplitude and kinetics of GPCR-dependent Read more at the source #DrGPCR #GPCR #IndustryNews

2022 "The very large G protein-coupled receptor (VLGR1, ADGRV1) is the largest member of the adhesion GPCR Read more at the source #DrGPCR #GPCR #IndustryNews

September 2022 Biased GPCR signaling by the native parathyroid hormone-related protein 1 to 141 relative understanding on how endogenous PTHrP transduces signals through its cognate G-protein coupled receptor (GPCR understanding of the biased signaling process of a native protein hormone acting in conjunction with a GPCR Read more at the source #DrGPCR #GPCR #IndustryNews

The cross-talk between growth factor receptors and GPCRs is an intriguing area of study. The primary research question addressed in this study was: How do growth factors, specifically through The researchers focused on the phosphorylation of the G protein subunit Gαi at specific residues within , leading to segregation of RTK-to-Gαi pathways from canonical GPCR-to-Gαi pathways. In conclusion, this research elucidates the molecular mechanisms by which growth factors influence G

the regulation of mTORC1 by upstream stimuli, with a specific focus on G-protein coupled receptor (GPCR

The GPCR Opportunity GPCRs are the largest and most diverse group of membrane receptors. A New Wave of GPCR Drug Discovery GPCRs are considered highly druggable, with GPCR-targeting therapeutics Small Protein GPCRs are Difficult to Drug Among the GPCRs that are challenging to drug using standard The Future of GPCR Research GPCRs are a very important class of drug targets, but despite historical Orion has entered a strategic research collaboration with Peptilogics, a US-based AI drug discovery company

GPCR Virtual Cafe is back! Our first guest speaker is none other than Dr. Ben Myers! Learn about communication between GPCRs and PKA, Class F GPCR Smoothened & the Hedgehog signaling pathway https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe

Methods & Updates in GPCR Research Discovery and design of G protein-coupled receptor targeting antibodies Fourth Quarter and Full Year 2022 Financial Results and Recent Highlights Salipro Biotech publishes research Research - Senior Scientist, Cell-Based Assay Development NEW Post Doctoral Fellow NEW Research associate in protein production NEW Vice President, Oncology Clinical Research NEW PostDoctoral Associate NEW GPCR Ecosystem

GPCR Event Spotlight    11th Adhesion GPCR Workshop    Location:  Mexico City Dates:  October 23-25, This week's highlight includes congrats to: Madison Walker , Benjamin Myers , et al., for their research Research Probing PAC1 receptor activation across species with an engineered sensor A Multi-Angle Approach Jobs Postdoc in GPCR mechanosensing   Postdoctoral Position Postdoctoral research position Senior or Lead Researcher   Senior Scientist, Cryo-Electron Microscopy   Postdoctoral Research Associate Become