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Despite its therapeutic potential, CB2 pharmacology remains difficult to interrogate with confidence. membrane mixtures, altered receptor conformations, and non-specific interactions introduce noise at precisely Early triage becomes more precise.   For researchers working in cannabinoid pharmacology, inflammation, or GPCR-mediated analgesia, these cellular context will be increasingly important for designing ligands with both potency and functional precision

The course covers basic pharmacology in four weekly segments. Only 14 out of 20 spots remain. , 2024 | 11th Adhesion GPCR Workshop July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology

Finally, we validated A2BAR as a potential pharmacological tool in CRC, using selective antagonists,

perception, and thought, and have the activation of serotonin (5-HT) 2A receptors (5-HT2A Rs) as a main pharmacological

Here, GPR15L(25-81) and GPR15L(71-81) are used as pharmacological tool compounds to delineate the GPR15

Despite considerable advances in pharmacological treatment, HF represents a severe clinical and social

Kenakin’s latest lecture delivers a paradigm shift for pharmacologists working on drugs where in vitro future topics Access to the study group Whether you’re in hit-to-lead, lead optimization, or clinical pharmacology

The pharmacological profiles and mechanistic insights of our study provide clues for the future design

Biased pharmacological modulators provide potential therapeutic benefits, including greater pharmacodynamic

non-medically for euphoric feelings and medically for pain relief, although the last one comes with pharmacological pathophysiological significance in pain, addiction and depression opioid receptors represent important pharmacological

In the realm of molecular research, precise interpretation is crucial; a misread curve can lead to lost Terry's Corner - The Truth About Allosteric Displacement Allosteric binding isn’t just a twist in the pharmacology Eliminate chaos tax:  Every two-week delay in DMTA cycles costs hundreds of thousands—avoidable with precision GPCR scientists, translational pharmacologists, biotech discovery teams, and decision-makers who need

on structure-function studies for membrane proteins in collaboration with AstraZeneca Expansion of precision (June 4 - 8, 2023). 2023 Molecular Pharmacology (GRS) Seminar GRC. (June 10 - 11, 2023). Adrenoceptors and GPCR Signalling (June 30 - July 1, 2023) 19th World Congress of Basic & Clinical Pharmacology Research NEW PostDoctoral Associate NEW PostDoctoral Position Team Lead protein production and profiling Pharmacologist

agricultural settings inspired him to train in veterinary medicine, where he was introduced to physiology and pharmacology Emerging direction: Peptide–drug conjugates for precision targeting.

together, these results will benefit further investigations to determine physiological functions and pharmacological

This innovation emerged from years of foundational work in photophysics and GPCR pharmacology.

Flow Cytometry validation performed in the Oncological Pharmacology Laboratory of the University of Turin

They provide rapid and scalable assessment of pharmacological parameters.

They unlocked pharmacologically relevant insights that were previously inaccessible.

Furthermore, targeting GPCRs in specific cellular compartments requires precise delivery mechanisms to Nuclear G-protein-coupled receptors as putative novel pharmacological targets. Frontiers in pharmacology, 9, 431. https://doi.org/10.3389/fphar.2018.00431

Activation of melatonin MT2 receptors with either pharmacological concentrations of melatonin (10-100

Postdoctoral Fellow, Caron Lab Clinical Trial Associate Research Scientist/Senior Scientist I - Molecular Pharmacology

receptors (SSTs) are class A GPCRs abundantly expressed in pituitary tumors where they represent the main pharmacological

effects of O-glycosylation and tyrosine sulfation modulation on the chemokine receptors CCR1 and CCR5 pharmacology evidence proposes that O-glycosylation and sulfation are important PTMs in chemokine receptor biology and pharmacology biological relevance of these PTMs in the chemokine receptor system which may ultimately allow for new precise

Postdoc Research Associate Director, Regulatory Affairs Research Scientist/Senior Scientist I - Molecular Pharmacology

Control of chondrocyte/chondroprogenitor Ca2+ signaling has been attempted through mechanical and/or pharmacological activation of endogenous Ca2+ signaling transducers; however, such approaches can lack specificity and/or precision Synthetic signaling platforms permitting precise and selective Ca2+ signal transduction can improve dissection We previously demonstrated hM3Dq's ability to precisely and synthetically initiate robust [Ca2+]i transients

FRET-based technologies by providing high-performance fluorescent ligands designed specifically for pharmacological

GPCRs demanded something different: the integration of modeling, medicinal chemistry, and pharmacology Pharmacologists know they aren’t being oversold. Overstating the precision of a model or the predictive power of an assay may look persuasive in the short A pharmacologist who understands docking, or a modeler who knows assay constraints, will collaborate

In this lesson, you'll gain: ✅ Clarity on what “irreversible” really means  in kinetic and pharmacologic

Postdoctoral Fellow, Caron Lab Clinical Trial Associate Research Scientist/Senior Scientist I - Molecular Pharmacology

The choice of pathway can result in different cellular responses, underscoring the criticality of precise Pharmacological Reviews, 71(2), 267-315. Lu, N., & Malemud, C. J. (2019).