Search Results

Sudha K Shenoy et al.

Nature chemical biology, 5(10), 734–742. https://doi.org/10.1038/nchembio.206 Wei, H., Ahn, S., Shenoy K., Karnik, S. S., Hunyady, L., Luttrell, L. M., & Lefkowitz, R. J. (2003). C., Götz, K., Sungkaworn, T., Lohse, M. J., & Calebiro, D. (2016). I., & O'Malley, K. L. (2017). A., Sriram, K., Wiley, S.

K., Gellman, S. H., Pautsch, A., Steyaert, J., Weis, W. I., & Kobilka, B. K. (2011). M., Manglik, A., Hu, J., Hu, K., Eitel, K., Hübner, H., Pardon, E., Valant, C., Sexton, P. I., Garcia, K. C., Wess, J., & Kobilka, B. K. (2013). D., Tworak, A., Watanabe, K., Pardon, E., Steyaert, J., Kandori, H., Katayama, K., Kiser, P. D., & Palczewski, K. (2023).

Wei, H., Ahn, S., Shenoy, S. K., Karnik, S. S., Hunyady, L., Luttrell, L. M., & Lefkowitz, R.

Shenoy, and R.J. Lefkowitz. 2006. Trafficking of G protein coupled receptors. Circ. K ´ onigstorfer, M. Mozhayeva, Y. Sara, T.C. Südhof, and ¨ E.T. Kavalali. 2001.

K., & Jacobson, K. A. (2010). Structure-based discovery of A2A adenosine receptor ligands. K., Bouvier, M., & Babu, M. M. (2023). L., Gregory, K. J., White, P. J., Sexton, P. M., Christopoulos, A., & May, L. T. (2016).

To validate that the developed assay is suitable for measuring the K i of different ligands, competition The Log(IC50) change in time was fitted with equation  3  and k given is the weighted average from 3  D.; Hanada, K.; Pagano, R. E.; Miller, L. J. -J.; Veiksina, S.; Kõlvart, K. R.; Min, M.; Kopanchuk, S.; Rinken, A. C.; Chen, K. H.; Bates, M.; Zhuang, X.

K., Das, A. K., Eds.; Elsevier, 2023; Vol. 103, pp 59–103. https://doi.org/10.1016/bs.coac.2023.02.005 .

and mastering drug binding kinetics is essential for pipeline efficiency: How fast a ligand binds (k₁ ) and how long it stays bound (k₂)  can alter therapeutic profiles dramatically, even if two candidates

.; Vemuri, K.; Pu, M.; Qu, L.; Han, G. (3), 750-762.e14. https://doi.org/10.1016/j.cell.2016.10.004 . (5)         Li, X.; Hua, T.; Vemuri, K. -H.; Wu, Y.; Wu, L.; Popov, P.; Benchama, O.; Zvonok, N.; Locke, K.; Qu, L.; Han, G. W.; Iyer, M. 382–389. https://doi.org/10.1021/acs.bioconjchem.7b00680 . (13)      Gazzi, T.; Brennecke, B.; Atz, K. .; Van Der Wel, T.; Mandhair, H.; Honer, M.; Fingerle, J.; Scheffel, J.; Broichhagen, J.; Gawrisch, K.

K., Selent, J., Hill, S. J., & Calebiro, D. (2023). M., Kawakami, K., Masureel, M., Maeda, S., Garcia, K. C., von Zastrow, M., Inoue, A., & Kobilka, B. K. (2022). Membrane phosphoinositides regulate GPCR-β-arrestin complex assembly and dynamics.

assays):  Displacement of specific radiolabeled ligands in CHO, HeLa, or HEK-293 cells, expressed as K References Kumar V, Chunchagatta Lakshman PK, Prasad TK, Manjunath K, Bairy S, Vasu AS, Ganavi B, Jasti

K., Bouvier, M., & Babu, M. M. (2023). K., Hoppe, N., Huang, X. P., Macdonald, C. B., Mehrota, E., Grimes, P.

K., Strader, D. J., Benovic, J. L., Dohlman, H. G., Frielle, T., Bolanowski, M. A., Bennett, C. K., Hildebrand, P. W., & Skiniotis, G. (2023).

reveal recognition motifs for the MRGPRD GPCR Chunyu Wang ,  Yongfeng Liu ,  Marion Lanier ,   Brian K adenocarcinoma, β-blockers and antihistamines: A clinical trial is needed Jillian G Baker ,  Erica K

Brian K. Shoichet, Dr. Luc Van Hijfte and Dr. Wendy Young.

receptor (GPCR) pharmacogenomics Miles D Thompson , David Reiner-Link , Alessandro Berghella , Brinda K Family A GPCR Jun Xu , Geng Chen , Haoqing Wang , Sheng Cao , Jie Heng , Xavier Deupi , Yang Du , Brian K

Lin S, Schorpp K, Rothenaigner I, Hadian K. Image-based high-content screening in drug discovery.

extracellular signal-regulated kinases 1/2 (ERK1/2) signaling, p38 signaling, mitochondrial respiration and Na+/K+

Jang W, Senarath K, Feinberg G, Lu S, Lambert NA.

Schlander M, Hernandez-Villafuerte K, Cheng CY, Mestre-Ferrandiz J, Baumann M. Dave K, Gelman H, Thu CT, Guin D, Gruebele M. Kim K, Che T, Panova O, DiBerto JF, Lyu J, Krumm BE, et al. Truong ME, Bilekova S, Choksi SP, Li W, Bugaj LJ, Xu K, et al.

through G-protein-coupled receptors (GPCRs), fine-tune motoneuron (MN) IME by modulating background K+

hydrogen-deuterium exchange (HDX) mass spectrometry for time-dependent conformational insights (Komolov, K. proteins, presenting an array of effectors that could be recruited to GPCR–β-arrestin complexes (Xiao, K

Research Transcriptome analysis of Schizothorax oconnori (Cypriniformes: Cyprinidae) oocytes: The role of K+

This week's highlight includes congrats to: Makaía M Papasergi-Scott, Peter Gmeiner, Brian K Kobilka,

Cell death signaling in Anopheles gambiae initiated by Bacillus thuringiensis Cry4B toxin involves Na+/K+

K., Hoppe, N., Huang, X.-P., Macdonald, C. B., Mehrotra, E., Patrick Rockefeller Grimes, Zahm, A.

BERKY consists of a membrane linker, a BRET donor, an ER/K α-helix linker, a BRET acceptor, and an active

act as dynamic pharmacological entities Marina Casiraghi, Robert J Lefkowitz, Peter Gmeiner, Brian K

full control of signaling activity through a small protein GPCR via library-based screening Dorgham, K. candidate hits from library-based screening so that they can be tested in cell-based assays Akondi, K. small proteins show full in vivo efficacy in a highly stringent model of HIV transmission Steinbach, K.