Search Results

tissue damage Intracellular pocket conformations determine signaling through the μ opioid receptor GPCR Binders

GPCR Binders, Drugs, and more MRAP2 regulates energy homeostasis by promoting primary cilia localization

GPCR Binders, Drugs, and more Adenylyl cyclase 6 plays a minor role in the mouse inner ear and retina

In structured, diffusion-restricted environments (e.g. brain, tumors), drugs don't just leave slowly;

activate an endogenous receptor and suppress heart rate in the Pacific abalone Haliotis discus hannai GPCR Binders

instead of cAMP Olanzapine manipulates neuroactive signals and may onset metabolic disturbances GPCR Binders

Pathways Activation of a GPCR, ORL1 receptor: A novel therapy to prevent heart failure progression GPCR Binders

GPCR Binders, Drugs, and more Adenosine A2A Receptor (A2AAR) Ligand Screening Using the 19F-NMR Probe

β-arrestin-dependent and -independent endosomal G protein activation by the vasopressin type 2 receptor GPCR Binders

CB1R are mainly found in the central nervous system (CNS) and the brain.

shows data from risperidone, comparing offset rates in open compartments vs. restricted ones like the brain

signaling pathway Deciphering specificity and cross-reactivity in tachykinin NK1 and NK2 receptors GPCR Binders

chronic ethanol drinking GRK5 is required for adipocyte differentiation through ERK activation GPCR Binders

GPCR Binders, Drugs, and more Development of a V5-tag-directed nanobody and its implementation as an

GPCR Binders, Drugs, and more Inhibiting a promiscuous GPCR: iterative discovery of bitter taste receptor

GPCR Binders, Drugs, and more A snake toxin as a theranostic agent for the type 2 vasopressin receptor

GPCRs Location-biased activation of the proton-sensor GPR65 is uncoupled from receptor trafficking GPCR Binders

self-renewal and pluripotency of mouse embryonic stem cells via JAK1/STAT3 signaling pathway GPCR Binders

GPCR Binders, Drugs, and more Autoantibodies targeting G protein-coupled receptors: An evolving history

real-time internalization of nine GPCRs reveals distinct dependence on arrestins and G proteins GPCR Binders

and Signaling Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation GPCR Binders

failure GPCR Activation and Signaling Positive allosteric modulation of a GPCR ternary complex GPCR Binders

These aren’t just “stronger binders.”

inhibiting GRP75-mediated endoplasmic reticulum-mitochondrial coupling in diabetic retinopathy GPCR Binders

GPCR Binders, Drugs, and more In-depth molecular profiling of an intronic GNAO1 mutant as the basis for

into agonist-dependent signalling bias at the pro-inflammatory G-protein coupled receptor GPR84 GPCR Binders

Metabolic Disease and GLP-1 After his PhD, Hodson entered neuroendocrinology — the “interface” between brain

GPCR Binders, Drugs, and more Discovery of SYD5115, a novel orally active small molecule TSH-R antagonist

stem cell loss Activation of Polycystin-1 Signaling by Binding of Stalk-derived Peptide Agonists GPCR Binders

ATP via P2X4 receptor] Osmotic stress studies of G-protein-coupled receptor rhodopsin activation GPCR Binders