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Sphingosine-1-phosphate activates LRRC8 volume-regulated anion channels through Gβγ signalling GPCR Binders

Recordings in brain slices have shown that co-activation using saturating concentrations of agonists

tissue damage Intracellular pocket conformations determine signaling through the μ opioid receptor GPCR Binders

and mGluR2-mediated increase in pathogenic tau but also show that β-arrestin1 levels are increased in brains

GPCR Binders, Drugs, and more MRAP2 regulates energy homeostasis by promoting primary cilia localization

GPCR Binders, Drugs, and more Adenylyl cyclase 6 plays a minor role in the mouse inner ear and retina

In structured, diffusion-restricted environments (e.g. brain, tumors), drugs don't just leave slowly;

I’m running into a problem and I know you work on something similar — can I pick your brain for one minute

activate an endogenous receptor and suppress heart rate in the Pacific abalone Haliotis discus hannai GPCR Binders

instead of cAMP Olanzapine manipulates neuroactive signals and may onset metabolic disturbances GPCR Binders

Pathways Activation of a GPCR, ORL1 receptor: A novel therapy to prevent heart failure progression GPCR Binders

GPCR Binders, Drugs, and more Adenosine A2A Receptor (A2AAR) Ligand Screening Using the 19F-NMR Probe

β-arrestin-dependent and -independent endosomal G protein activation by the vasopressin type 2 receptor GPCR Binders

chronic ethanol drinking GRK5 is required for adipocyte differentiation through ERK activation GPCR Binders

CB1R are mainly found in the central nervous system (CNS) and the brain.

signaling pathway Deciphering specificity and cross-reactivity in tachykinin NK1 and NK2 receptors GPCR Binders

GPCR Binders, Drugs, and more Development of a V5-tag-directed nanobody and its implementation as an

shows data from risperidone, comparing offset rates in open compartments vs. restricted ones like the brain

GPCR Binders, Drugs, and more Inhibiting a promiscuous GPCR: iterative discovery of bitter taste receptor

GPCR Binders, Drugs, and more A snake toxin as a theranostic agent for the type 2 vasopressin receptor

self-renewal and pluripotency of mouse embryonic stem cells via JAK1/STAT3 signaling pathway GPCR Binders

GPCRs Location-biased activation of the proton-sensor GPR65 is uncoupled from receptor trafficking GPCR Binders

failure GPCR Activation and Signaling Positive allosteric modulation of a GPCR ternary complex GPCR Binders

These aren’t just “stronger binders.”

real-time internalization of nine GPCRs reveals distinct dependence on arrestins and G proteins GPCR Binders

GPCR Binders, Drugs, and more Autoantibodies targeting G protein-coupled receptors: An evolving history

and Signaling Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation GPCR Binders

inhibiting GRP75-mediated endoplasmic reticulum-mitochondrial coupling in diabetic retinopathy GPCR Binders

GPCR Binders, Drugs, and more In-depth molecular profiling of an intronic GNAO1 mutant as the basis for

company mantra Investor communication feels reactive and apologetic Key documents live in the CEO’s brain