Search Results

activation of mTOR complex 1 (mTORC1) is typically observed in human disease and continues to be an important

Serotonin1A receptors are important members of the GPCR family and are implicated in neuropsychiatric

Receptor Agonists "The increasing prevalence of obesity and type 2 diabetes (T2DM) is provoking an important

Serotonin1A receptors are important members of the GPCR family and are implicated in neuropsychiatric

sulfakinin receptor in the Chinese white pine beetle Dendroctonus armandi "The sulfakinin (SK) is an important

Whether and how RH affects responses within metabolically important peripheral organs to counterregulatory

This emphasizes the importance of the Gi/o (pertussis toxin-sensitive G proteins, whose βγ subunits activate

Subsequently, binding pocket hotspot residues that would be important for further computational mutagenesis

Modules: October 31st : The Eyes to See- The Importance of Pharmacologic Assays. Treatment of Hypoparathyroidism World first: Australian scientists uncover “plant-like” behavior in important

Our study demonstrates the importance of β-catenin lysine methylation in terms of its sustained expression

GPR84 activation imposes pro-inflammatory properties in colonic macrophages through enhancing NLRP3 inflammasome

Moreover, molecular docking was applied to valid the important interactions between the ingredients and

optimization and application to cell-based kinetic studies "G protein-coupled receptors (GPCRs) are an important

a strong correlation between one-point displacement and full concentration–response performance—an important nuanced understandings of CB2 signaling, tools that preserve cellular context will be increasingly important

Given the important roles of extracellular pH in the progression of pulmonary fibrosis, we sought to

September 2022 "The glucagon-like peptide-1 receptor (GLP-1R) plays a key role in metabolism and is an important

targets and pose particular challenges for X-ray crystallography, by cryo-EM has enabled insights into important

Together, our findings reveal an important suppressive role of ADGRA1 in anxiety control and synaptic

behavioral and pharmacokinetic profiles of the 5-HT2AR agonist DOI in C57BL/6J mice, and support the importance

One of the most important signaling pathways in higher eukaryotes is the phosphoinositide 3-kinase (PI3K

The company has long-standing expertise in G protein–coupled receptor (GPCR) biology—one of the most important

Moreover, the dysregulation of TLR4 contributes to numerous diseases, which highlights the importance

Unlocking the Puzzle: The Importance of Precision in GPCR Programs and the Hidden Costs of Overlooking

Artificial intelligence - Machine learning vs Deep Learning GPCRs have long been recognized as important signalling of GPCRs comes the possibility of designing drugs that selectively activate therapeutically important While AI holds great potential, it is important to note that it is not a replacement for experimental

This is particularly important when dealing with receptor subtypes that exhibit significant similarity coupling preference with downstream signaling components, such as β-arrestin and G-protein transducers, is important

Understanding the Connection Between Residence Time and Drug Efficacy: The Importance of Moving Beyond

the regulation of the physiological balance between healthy and pathological conditions; thus, their importance

understanding of the pathophysiology of hepatic fibrosis and the development of related therapies are of great importance

As researchers, we all understand the importance of data in driving meaningful discoveries  and advancing

understanding of the underlying molecular mechanisms and the identification of treatment targets is of utmost importance