August 2022 GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin The structural basis for G protein subtype selectivity by these GPCRs remains elusive. We find that the macro-switch by the TM5-TM6 length is shared by class A GPCR-G protein structures. results present a common mechanism of Gs versus Gi protein coupling selectivity or promiscuity by class A GPCRs Read more at the source #DrGPCR #GPCR #IndustryNews

GPCR Partnered Events March 5 - 7, 2024 | 3rd GPCRs - Targeted Drug Discovery Summit Exciting news! We're partnering again with the 3rd GPCRs - Targeted Drug Discovery Summit in Boston on March 5-7, 2024 Conformations: A Leap in Drug Discovery with STAGS Machine Learning Model Three GPCR Companies Earn will be presenting at the OBIO 2024 Investment Summit X-rays to AlphaFold: the future structure of drug 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 1 - 4, 2024 | 19th Annual Drug

GPCR Symposium on GPCR activation and signaling a resounding success! Terry Kenakin's "Applying Pharmacology to Drug Discovery" course at Dr. GPCR Partnered Events April 22 - 23, 2024 | Endocrine Metabolic GPCRs Join the Endocrine Metabolic GPCRs 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 1 - 4, 2024 | 19th Annual Drug GPCR Ecosystem

regulating the dynamics of the serotonin1A receptor, a crucial neurotransmitter G protein-coupled receptor (GPCR in understanding the modulatory role of the membrane environment on the organization and dynamics of GPCRs Read more at the source #DrGPCR #GPCR #IndustryNews

signaling cascade GPCR Binders, Drugs, and more Biased agonists of GPR84 and insights into biological IpRGCs Synaptic plasticity via receptor tyrosine kinase/G-protein-coupled receptor crosstalk Optimized design Research Direct Binding Methods to Measure Receptor-Ligand Interactions How accurately can one predict drug - Targeted Drug Discovery Summit March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 1 - 4, 2024 | 19th Annual Drug

Hi GPCR lovers! Binders, Drugs, and more Design and structural validation of peptide-drug conjugate ligands of the kappa-opioid , and more Structure, function and drug discovery of GPCR signaling Illuminating the understudied GPCR-ome - Targeted Drug Discovery Summit March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 1 - 4, 2024 | 19th Annual Drug

Check out our GPCR coverage for this week. GPCR Symposia Join us on June 7th for our symposium on Structural and Molecular Insights into GPCR Function Let’s dive into the Classified GPCR News from April 22nd to 28th, 2024 Adhesion GPCRs Dysfunction of Binders, Drugs, and more Discovery and development of macrocyclic peptide modulators of the cannabinoid GPCR Ecosystem

We’ve curated 18 GPCR papers, 8 industry news, and 2 GPCR job offers! Binders, Drugs, and more Chimeric antigens displaying GPR65 extracellular loops on a soluble scaffold Showcase™ 2024 Establishing our first international translational research project - Institute for Protein Design - Targeted Drug Discovery Summit March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 1 - 4, 2024 | 19th Annual Drug

Binders, Drugs, and more Discovery of Guanfacine as a Novel TAAR1 Agonist: A Combination Strategy through Function Structural and signaling mechanisms of TAAR1 enabled preferential agonist design Proteome-wide Showcases Innovative AI-Driven Drug Design at BRIC AI 2023 Workshop Salipro Biotech AB Celebrates Milestones - Targeted Drug Discovery Summit March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 1 - 4, 2024 | 19th Annual Drug

Screening System: A High-Throughput Engineering Platform for Genetically Encoded Fluorescent Indicators Design Welcomes Melissa Faris as Chief Business Officer Septerna: Revitalizing G-Protein Coupled Receptor Drug Discovery Orion’s VP Drug Discovery, Dr. Healthcare Meet At Novartis Neurocrine Biosciences Announces Settlement of INGREZZA Abbreviated New Drug - Targeted Drug Discovery Summit March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar

Binders, Drugs, and more Semi-synthetic nanobody-ligand conjugates exhibit tunable signaling properties Agreement with Bridge Biotherapeutics in Idiopathic Pulmonary Fibrosis Former execs from Pfizer obesity drug - Targeted Drug Discovery Summit March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 1 - 4, 2024 | 19th Annual Drug GPCR Ecosystem

Submit your logo design by Nov 1st on the Logo Contest page. : Allosteric activation of the ERK MAPK by β-arrestin GPCR Binders, Drugs, and more Pharmacologically targeting intracellular allosteric sites of GPCRs for drug discovery Targeting mGluR group III for the neurological disease for novel drug discovery Application of bioluminescence resonance energy transfer to Buy Hypertension Treatment from KBP Biosciences Exscientia to Present New Preclinical Data for AI-designed

Submit a logo design by Nov 1st on the Logo Contest page. No registration is needed to submit your logo design. Subscribe to Dr. is essential for meiosis and ascosporogenesis in the wheat scab fungus GPCR Binders, Drugs, and more Development of Photoswitchable Tethered Ligands that Target the µ-Opioid Receptor Design and Synthesis Ozempic kidney trial after early signs of success Sosei and PharmEnable extend neurological disease drugs

Terry Kenakin’s Applying Pharmacology to Drug Discovery course. agonists for exploration of GLP-1R ligand effects in pancreatic β-cells and neurons GPCR Binders, Drugs activity: implications for drug discovery and development GPCRs in Neuroscience Scutellaria baicalensis Discovery & Development In Endocrine And Metabolic Diseases How biotech companies are using AI to design drugs GPCR Therapeutics Announces Publication in PNAS Using Cutting Edge Spectroscopy to Detect GPCR

Hi there GPCR minds! Join us for a deep dive into the world of GPCRs. GPCR Symposium for the year on GPCRs in Immunology and Oncology! Binders, Drugs, and more GPC-100, a novel CXCR4 antagonist, improves in vivo hematopoietic cell mobilization Jobs NEW Staff Scientist (AC-TAP) in Database Development at Department of Drug Design and Pharmacology GPCR Ecosystem

5HT2C-transducer-coupled structures of three representative isoforms (INI, VGV, and VSV) with the selective drug network located on intracellular loop 2 that is subject to RNA editing, which differentially affects GPCR Read more at the source #DrGPCR #GPCR #IndustryNews

GPCR, was featured as Superluminal Medicines Launches to Drug Protein Conformations in a Flash. body receptor HCAR2 suppresses inflammation GPCR Binders, Drugs, and more Saturated Cannabinoids: Update in a Flash Andrew Hopkins, Exscientia's CEO, Recognized in TIME Magazine's for Pioneering AI-Driven Drug the Barriers: Unlocking the Future of Ion Channel Drug Discovery with Cryo-EM September 25 - 28, 2023 | Discovery On Target September 27 - 28, 2023 | Training Seminar "The Renaissance in GPCRs as Drug Targets

February 2022 Trevena Announces Submission of New Drug Application in China for OLINVYK® by its Partner announced that China’s National Medical Products Administration (NMPA) has accepted submission of a New Drug oliceridine) injection, a novel IV analgesic that has been approved in the United States by the Food and Drug Read more at the source #DrGPCR #GPCR #IndustryNews

GPCR Symposium about 'GPCRs as Therapeutic Modalities' rocked it! Submit your logo design by November 1st. You don't need to be registered to participate. , Drugs, and more An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric Carolina semaglutide plant Excellerate Bioscience Announces Site Relocation AI can help to speed up drug CB1 receptor antagonists BenevolentAI, Exscientia on the comeback trail after securing separate AI drug

GPCR Symposium on 'GPCRs as Therapeutic Modalities'. Binders, Drugs, and more Altered G-Protein Transduction Protein Gene Expression in the Testis of Infertile , and more Key Aspects of Modern GPCR Drug Discovery Location bias: A "Hidden Variable" in GPCR pharmacology extracellular domain Industry News Superluminal Medicines Launches with $33 Million Seed Round to Fuel its Drug Target September 27 - 28, 2023 | Training Seminar "The Renaissance in GPCRs as Drug Targets: Allosteric

Hello GPCR people! Check out our GPCR roundup now, and be the first to read! distinct dependence on arrestins and G proteins GPCR Binders, Drugs, and more Studying allosteric regulation and Signaling Protein Research Tools First-In-Class Drug Shows Potential for Treatment of Cannabis Use Target September 27 - 28, 2023 | Training Seminar "The Renaissance in GPCRs as Drug Targets: Allosteric GPCR Ecosystem

GPCR University Course, ‘Applying Pharmacology to Drug Discovery,’ led by Dr. GPCR Partnered Events April 22 - 23, 2024 | Endocrine Metabolic GPCRs Join the Endocrine Metabolic GPCRs Research Cryo-electron microscopy for GPCR research and drug discovery in endocrinology and metabolism clinic (Review) Will the hype of automated drug discovery finally be realized? 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 1 - 4, 2024 | 19th Annual Drug

to Drug Discovery,' which will be led by Dr. GPCR Partnered Events March 5 - 7, 2024 | 3rd GPCRs - Targeted Drug Discovery Summit Join us at the 3rd Activation and Signaling GPCR signaling bias: an emerging framework for opioid drug development Structural Binders, Drugs, and more Insights on discovery, efficacy, safety and clinical applications of ghrelin feature fusion-based deep learning for GPCR-drug interaction prediction Structural and Molecular Insights

GPCR Symposium on 'GPCRs as Therapeutic Modalities'. and oligomerization Molecular Insights into GPCR Mechanisms for Drugs of Abuse Industry News 'GPCR Therapeutics Clinical Pharmacology Sosei and Cancer Research UK announce first patient dosed with oral immunotherapy drug as Drug Targets: Allosteric Function and Biased Signaling" at the DOT (September 27 - 28, 2023) 3rd November 15 -17, 2023) ASCEPT Annual Scientific Meeting (November 20 -23, 2023) Structure, Mechanism, and Drug

Hello GPCR people! Check out our GPCR roundup now, and be the first to read! Submit a logo design by Nov 1st on the Logo Contest page. No registration is needed to submit your logo design. Subscribe now to Dr. GPCR Binders, Drugs, and more In silico identification of a biarylamine acting as agonist at human β3 GPCR Ecosystem

November 2022 "Adhesion G-protein-coupled receptors (aGPCRs) play key roles in a diversity of physiologies A hallmark of aGPCR activation is the removal of the inhibitory GAIN domain and the dipping of the cleaved The structures also reveal the uncharted structural information of GPCR/G12 coupling. A detailed analysis of the engagements allows us to design mutations that specifically enhance one pathway Read more at the source #DrGPCR #GPCR #IndustryNews Subscribe to the Dr. GPCR Newsletter HERE

GPCR Symposium on Structural and Molecular Insights on GPCR Activation! GPCR Binders, Drugs, and more Allosteric modulator potentiates β2AR agonist-promoted bronchoprotection Methods & Updates in GPCR Research Evaluation of Drug Responses to Human β2AR Using Native Mass Spectrometry NEW MPGPCR Conference (November 15 -17, 2023) Structure, Mechanism, and Drug Interactions of GPCRs, Ion Sciences - Surgery NEW Senior Scientist- Membrane Technologies NEW Computational Protein Design (GPCR

GPCR Newsletter! Research UK Announce the Dosing of the First Patient in a Phase I/IIa Trial with Cancer Immunotherapy Drug as Drug Targets: Allosteric Function and Biased Signaling" at the DOT (September 27 - 28, 2023) 3rd November 15 -17, 2023) ASCEPT Annual Scientific Meeting (November 20 -23, 2023) Structure, Mechanism, and Drug GPCR Ecosystem