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Several neurotransmitters and neuromodulators, acting through G-protein-coupled receptors (GPCRs), fine-tune

Molecular basis of proton-sensing by G protein-coupled receptors. bioRxiv .

μg/L in C. elegans The aim of this study was to identify Gα proteins mediating function of neuronal G

appears to be a second high-affinity site may simply reflect kinetic factors—such as ligand-receptor-G

Methods & Updates in GPCR Research A coiled-coil-based design strategy for the thermostabilization of G-protein-coupled

GPCR Activation and Signaling β-Arrestin-dependent and -independent endosomal G protein activation by

GPCRs in Neuroscience Heterotrimeric G proteins regulate planarian regeneration and behavior.

acid derivatives as a new class of GPR34 antagonists Larixol is not an inhibitor of Gαi containing G

GPCR Function AlphaFold3 versus experimental structures: assessment of the accuracy in ligand-bound G

References Kumar V, Chunchagatta Lakshman PK, Prasad TK, Manjunath K, Bairy S, Vasu AS, Ganavi B, Jasti

Game-Changing GPCR-Targeting Immunotherapies at Sachs Associates' Biotech Forum Celtarys Research and G-CLIPS

Trafficking of G protein coupled receptors. Circ. Res. 99:570–582. Jurado, S., D. Goswami, Y.

heterodimer is a potent neutrophil chemoattractant Methods & Updates in GPCR Research GproteinDb in 2024: new G

Industry News OMass Therapeutics Welcomes Melissa Faris as Chief Business Officer Septerna: Revitalizing G-Protein

Pancreatic ductal adenocarcinoma, β-blockers and antihistamines: A clinical trial is needed Jillian G

G protein-coupled receptor pharmacology - insights from mass spectrometry.

Small-molecule targeting of GPCR-independent non-canonical G protein signaling inhibits cancer progression

Upcoming events:  An exclusive preview of the “neuroGPCR: G protein coupled receptor signaling in its

and Exhibition June 2 - 7, 2024 | Chemotactic Cytokines June 9 - 14, 2024 | 2024 Phosphorylation and G-Protein

impacting receptor/ligand-binding and signaling patterns, by modulating ligand binding, as well as G-protein

This is a core GPCR pharmacology insight:ligand → receptor → G protein is never the entire story.

and Exhibition June 2 - 7, 2024 | Chemotactic Cytokines June 9 - 14, 2024 | 2024 Phosphorylation and G-Protein

Exendin-4, and possibly through G protein-coupled receptors (GPCRs), increases levels of cAMP and upregulates

Odorant receptors function and expression landscape Odorant receptors (ORs) belong to the G protein-coupled