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Nonetheless, we determined that mGlu5a internalization was not altered upon the loss of cPKCs or nPKCs

To test if this loss of PM localization could contribute to the mechanism of inhibition of αqQ209L by

The axonal degeneration that occurs before retinal ganglion neuronal loss is suggested to be involved

oriental fruit moth Grapholita molesta is a cosmopolitan pest of orchard, which causes serious economic losses

The takeaway is clear: fast clearance does not necessarily mean loss of efficacy  when binding offset

Breakthroughs this week:  Orphan receptor GPRC5B in neurogenesis; Septerna’s pill-based weight-loss strategy

discoveries could revolutionise women’s health Seven unanswered questions about blockbuster weight-loss

DR curves shift to the right with no loss of maximal effect.

novel fluorescent Endothelin-B receptor probes GPCRs in Cardiology, Endocrinology, and Taste GPRASP1 loss-of-function

loop 2 in the β2-adrenergic receptor mediates interactions with G protein and β-arrestin with a biased loss

Build theories, but be ready to toss them.

was significantly diminished iin Gαi KO and Gα_all KO HEK293 cells, however there was only a minor loss HEK293 cells with CRISPR KO of both β-arrestin1 and β-arrestin2 only led to a small but measurable loss

analysis Reviews, GPCRs, and more Parallel evolution of the G protein-coupled receptor GrlG and the loss

Heptares to Host R&D Day Highlighting its Innovative R&D and Late-Stage Development Progress Parker Moss

Industry News Data shows nearly 19% weight loss in people with overweight or obesity in Boehringer Ingelheim

dive into the Classified GPCR News from April 1st to 7th, 2024 GPCR Activation and Signaling GPRASP1 loss-of-function

Months of wasted resources, failed translation, and opportunity loss.

Ines Liebscher, Ross Cheloha and Silvio Gutkind.

Loss of biased signaling at a G protein-coupled receptor in overexpressed systems.

Postdoc in GPCR mechanosensing   Postdoctoral Position Postdoctoral research position Adhesion GPCRs Loss

Rodriguez, P.J., et al., Semaglutide vs Tirzepatide for Weight Loss in Adults With Overweight or Obesity

activation RhoA-mediated G12-G13 signaling maintains muscle stem cell quiescence and prevents stem cell loss

Canonical chemokine receptors as scavenging “decoys” Shivani Sachdev, Brendan Creemer, Thomas Gardella, and Ross

Discovery of the Potent and Selective MC4R Antagonist PF-07258669 for the Potential Treatment of Appetite Loss

droplets; novel atypical GPCR-arrestin complexes; Lilly's oral GLP-1, orforglipron, delivers weight loss

Nayara Braga Emidio, Ross Cheloha, Laura M Wingler, et al. for their work on Nanobody-Mediated Dualsteric

Ross Bathgate, Francisco Olucha-Bordonau, et al.  

Ross Cheloha's research involves semi-synthetic nanobody-ligand conjugates with enhanced transcriptional

Structural and functional insight into the interaction of Clostridioides difficile toxin B and FZD7 Loss-of-function

from November 25th to December 1st, 2024 Industry News Amgen says obesity drug caused up to 20% weight loss