Search Results
Results found for "Robert J Lefkowitz"
- 📰 GPCR Weekly News, July 10 to 16, 2023
Robert J Lefkowitz. Join us tomorrow, July 21, in the Dr.
- 📰 GPCR Weekly News, September 11 to 17, 2023
Robert Lefkowitz on his 50 years at Duke. Congratulations. Dr. leukotriene G-protein coupled receptors Industry News Duke University Celebrates Nobel Prize Winner Robert Lefkowitz’s 50 Years of Scientific Discovery Novo Nordisk Foundation Grants Fuel Exciting GPCR and Signaling J. Lefkowitz's Career at Duke October 3, 2023, | FREE Seminar: Changing paradigm on Therapeutics targeting
- 📰 GPCR Weekly News, October 16 to 22, 2023
Robert J Lefkowitz and team's study 'GPCR signal transduction: β-arrestin activates ERK MAPK.' Dr. J. Silvio Gutkind.
- 📰 GPCR Weekly News, September 25 to October 1, 2023
Michel Bouvier, J Silvio Gutkind, and team found that Gαs is essential for GRK selectivity and gene regulation gap in cardiometabolic diseases GPCR Events, Meetings, and Webinars October 2 - 3, 2023 | Celebrating Robert J. Lefkowitz's Career at Duke October 3, 2023, | FREE Seminar: Changing paradigm on Therapeutics targeting
- 📰 GPCR Weekly News, September 18 to 24, 2023
Deadline September 27, 2023 GPCR Events, Meetings, and Webinars October 2 - 3, 2023 | Celebrating Robert J. Lefkowitz's Career at Duke October 3, 2023, | FREE Seminar: Changing paradigm on Therapeutics targeting
- Dr. Nicola J. Smith - Dr. GPCR Podcast
Next on the Dr. GPCR Podcast, we have Dr. Nicola Smith, Molecular Pharmacologist, lab head, and senior lecturer at UNSW Sydney. Subscribe to the podcast today and get notified when new episodes are released! Please share! https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ #gpcr #drgpcr #podcast
- 📰 GPCR Weekly News, April 8 to 14, 2024
Kozielewicz, et al. for their study on Frizzleds act as dynamic pharmacological entities Marina Casiraghi, Robert J Lefkowitz, Peter Gmeiner, Brian K Kobilka et al. for their investigation on Molecular insights into
- Exscientia welcomes Richard J. Law, as their new Chief Business Officer
March 2022 "Congratulations to Richard J. Law, our newly named Chief Business Officer.
- Dr. Peter Robert Banks - Dr. GPCR Podcast
Ep 57 of the Dr. GPCR podcast is now available! Our guest is Dr. Peter Banks, Scientific Director at BioTek Instruments! Learn about his career today! Listen where you get your podcasts. https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ #gpcr #drgpcr #podcast
- Ode to GPCRs
relevant to GPCR-mediated signaling was the 2012 Nobel Prize in Chemistry to Brian Kent Kobilka and Robert Joseph Lefkowitz for their work on GPCR function.[62–66] Lefkowitz was able to isolate β-adrenergic Later on, Kobilka joined in with Lefkowitz to identify the shared architecture of the β-adrenergic receptor Robert J. Lefkowitz – Facts - NobelPrize.org. https://www.nobelprize.org/prizes/chemistry/2012/lefkowitz/facts/
- From DNA day to GPCR genomics
discovery and sequencing of the beta-adrenergic receptor (βAR), the first GPCR to be identified by Robert Lefkowitz and colleagues during their study of the effects of adrenaline on cells2. J., Benovic, J. L., Dohlman, H. G., Frielle, T., Bolanowski, M. A., Bennett, C. G., Lefkowitz, R. J., & Strader, C. D. (1986).
- 📰 GPCR Weekly News, July 31 to August 6, 2023
Nichola J Smith's investigation: Gene expression of TAS1R taste receptors for cardiometabolic disease Robert Lefkowitz Lab Postdoc Fellow - Dr. Robert Lefkowitz Lab Senior Research Specialist - Natural Sciences - Surgery Senior Scientist- Membrane
- 📰 GPCR Weekly News, August 7 to 13, 2023
Robert Lefkowitz Lab Postdoc Fellow - Dr. Robert Lefkowitz Lab Explore Dr. GPCR Ecosystem
- Septerna emerges with $100M to spark 'second golden age' of prolific drug target GPCR with ...
The company's co-founder, GPCR pioneer and Nobel laureate Robert Lefkowitz, M.D., has 50 years of experience
- Unlocking Cell's Secrets: Spontaneous β-Arrestin-Membrane Preassociation Drives Receptor-Activation
M., Medel-Lacruz, B., Baidya, M., Makarova, M., Mistry, R., Goulding, J., Drube, J., Hoffmann, C., Owen K., Selent, J., Hill, S. J., & Calebiro, D. (2023). Cell, 186(10), 2238–2255.e20. https://doi.org/10.1016/j.cell.2023.04.018 Janetzko, J., Kise, R., Barsi-Rhyne Nature 557, 452–456. https://doi.org/10.1038/s41586-018-0077-3 Pierce, K.L., and Lefkowitz, R.J. (2001 Reiter, E., Ahn, S., Shukla, A.K., and Lefkowitz, R.J. (2012).
- 📰 GPCR Weekly News, July 17 to July 23, 2023
Robert Lefkowitz Lab NEW Postdoc Fellow - Dr. Robert Lefkowitz Lab Senior Research Specialist - Natural Sciences - Surgery Senior Scientist- Membrane
- 📰 GPCR Weekly News, July 24 to July 30, 2023
Robert Lefkowitz Lab Postdoc Fellow - Dr. Robert Lefkowitz Lab Senior Research Specialist - Natural Sciences - Surgery Senior Scientist- Membrane
- An overview of the compartmentalized GPCR Signaling: Relevance and Implications
S., Sousa, J. B., Gonçalves, J., & Diniz, C. (2019). N., Castro, M., Wang, B., Bouley, R., Potts, J. T., Gardella, T. J., & Vilardaga, J. P. (2009). M., & Lefkowitz, R. J. (2003). J., & Calebiro, D. (2016). J., & Calebiro, D. (2017).
- The Perils and Guardrails of Modifying Signalling Proteins in Bioassays
Wouters OJ, McKee M, Luyten J. J Health Econ. 2016;47:20-33. 8. Liu S, Anderson PJ, Rajagopal S, Lefkowitz RJ, Rockman HA. Lu S, He X, Ni D, Zhang J. Changeux J-P, Christopoulos A.
- Decoding GPCR Function: The Role of Mutagenesis in Rational Drug Discovery
Reference Bikker, J. A., Trumpp-Kallmeyer, S., & Humblet, C. (1998). Carlsson, J., Yoo, L., Gao, Z. G., Irwin, J. J., Shoichet, B. K., & Jacobson, K. A. (2010). Di Roberto, R. B., Chang, B., & Peisajovich, S. G. (2017). T., Baltos, J.-A., Thomas, T., Nguyen, T. D., Muñoz, L. L., Gregory, K. J., White, P. J., Sexton, P. M., Christopoulos, A., & May, L. T. (2016).
- Extracellular signal-regulated kinases – a potential pathway for GPCR-targeted drug discovery
J. (2019). Volmat, V., & Pouysségur, J. (2001). Spatiotemporal regulation of the p42/p44 MAPK pathway. M., & Lefkowitz, R. J. (2003).
- A robust and Efficient FRET-Based Assay for Cannabinoid Receptor Ligands Discovery.
.; Tuisku, J. M.; Hirvonen, J. E. S.; Vahlberg, T.; Lahdenpohja, S.; Rinne, J. O.; Brück, A. E. J. Med. Der Wel, T.; Mandhair, H.; Honer, M.; Fingerle, J.; Scheffel, J.; Broichhagen, J.; Gawrisch, K.; Romero , J.; Hillard, C. .; Hénichart, J.-P.
- Conjugation Strategies for Probe Development
.; Boström, J. J. Med. Chem. 2016 , 59 (10), 4443–4458. https://doi.org/10.1021/acs.jmedchem.5b01409 . .; Salvador Andresa, J.; Allongue, P.; Chazalviel, J.-N.; Gouget-Laemmel, A. (3) Fan, J.; Toth, I.; Stephenson, R. J.
- 📰 GPCR Weekly News, October 2 to 8, 2023
‘Define your own success’: Duke leaders talk success, failure at symposium honoring Nobel Laureate Robert Lefkowitz Integral Molecular Secures Nearly $900K in NIH Funding to Discover Antibodies Against Difficult
- Nanobodies: New Dimensions in GPCR Signaling Research
J., Fung, J. J., Pardon, E., Casarosa, P., Chae, P. S., Devree, B. T., Rosenbaum, D. M., Thian, F. H., Pautsch, A., Steyaert, J., Weis, W. I., & Kobilka, B. K. (2011). M., Manglik, A., Hu, J., Hu, K., Eitel, K., Hübner, H., Pardon, E., Valant, C., Sexton, P. C., Gmeiner, P., Steyaert, J., Weis, W. I., Garcia, K. C., Wess, J., & Kobilka, B. K. (2013). Nature, 504(7478), 101–106. https://doi.org/10.1038/nature12735 Burg, J. S., Ingram, J.
- Fluorescence Polarization in GPCR Research
Adapted from: Zhang Y, Tang H, Chen W, Zhang J. Int J Mol Sci. 2022 Aug 3;23(15):8625 . Miranda-Pastoriza D, Bernárdez R, Azuaje J, Prieto-Díaz R, Majellaro M, Tamhankar AV, Koenekoop L, González A, Gioé-Gallo C, Mallo-Abreu A, Brea J, Loza MI, García-Rey A, García-Mera X, Gutiérrez-de-Terán H,
- 📰 GPCR Weekly News, February 26 to March 3, 2024
Robert Lefkowitz for their work on GPCRs: from radioligand binding to cellular signaling Dr.
- Do You Believe AI Could Accelerate Drug Discovery?
References: Lyu, J. et al. AlphaFold2 structures guide prospective ligand discovery. Science https://doi.org/10.1126/science.adn6354 (2024) Abramson, J., Adler, J., Dunger, J. et al.
- Optimizing HTRF Assays with Fluorescent Ligands: Time-Resolved Fluorescence in GPCR Research
Int J Mol Sci. 2014 Feb 13;15(2):2554-72. Source: Navarro G, Sotelo E, Raïch I, Loza MI, Brea J, Majellaro M. References Navarro G, Sotelo E, Raïch I, Loza MI, Brea J, Majellaro M. Int J Mol Sci. 2014 Feb 13;15(2):2554-72. doi: 10.3390/ijms15022554.
- Fluorescence based HTS compatible ligand binding assays for dopamine D3 receptors in baculovirus preparations and live cells
, J. H.; Winkelman, J. , J.; Allen, R. J. J. Med.