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pharmacology' Yao Lu and colleagues work on 'Molecular insights into orphan GPCRs relevant to schizophrenia' Carole Scientific Meeting NEW February 3 - 7, 2024 | SLAS2024 International Conference and Exhibition NEW March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar NEW March 24 - 29, 2024 | Ligand Recognition

Canonical chemokine receptors – scavenging “decoys” Chemokine receptors coordinate cell migration upon The chemokine receptor family comprises 19 canonical chemokine receptors together with 4 atypical chemokine Although less characterized, canonical chemokine receptor systems have been also shown to not only directly CCR2 canonical signaling requires the activation of Gαiβγ, followed by phosphorylation of the receptor But why do canonical chemokine receptors have this dual role in physiology?

February 16 - 21, 2025 | Harnessing the Power of Advanced Multimodal Approaches to GPCR Drug Discovery March 12 - 14, 2025 | NextGen Biomed 2025 March 25 - 28, 2025 | 10th German Pharm-Tox Summit April 1 - 5, Chemistry GPCR Activation and Signaling SNX9 family mediates βarrestin-independent GPCR endocytosis A non-canonical

GPCR Symposia Mark your calendars! In just two weeks, on March 15th, we are hosting a symposium on GPCR activation and signaling. GPCR Partnered Events March 5 - 7, 2024 | 3rd GPCRs - Targeted Drug Discovery Summit. Join Dr. Yamina Berchiche at the 3rd GPCRs Summit in Boston on March 5-7, 2024. Dr. 13 - 15 | Biologics 2024 March 13 - 15 | 9th German Pharm-Tox Summit March 23 - 24, 2024 | Ligand Recognition

Check out our new on-demand course on non-canonical GPCR behaviors and a podcast episode tracing 30 years

GPCR Symposia Our upcoming symposium on March 15th is about GPCR activation and signaling. GPCR Partnered Events March 5 - 7, 2024 | 3rd GPCRs - Targeted Drug Discovery Summit Join us at the 3rd GPCRs Summit in Boston on March 5-7, 2024. 13 - 15 | 9th German Pharm-Tox Summit March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 1 - 4, 2024 |

More specifically, this review covers assays to monitor the canonical G protein signaling pathway (e.g recruitment/activation, inositol phosphate accumulation, or Ca2+ mobilization), assays to monitor non-canonical

GPCR Symposia Our upcoming symposium on March 15th is about GPCR activation and signaling. GPCR Partnered Events March 5 - 7, 2024 | 3rd GPCRs - Targeted Drug Discovery Summit Join us at the 3rd GPCRs Summit in Boston on March 5-7, 2024. 13 - 15 | 9th German Pharm-Tox Summit March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 1 - 4, 2024 |

Johannes “JB” Broichhagen trained as a synthetic chemist — someone who trusted carbon–carbon bonds far

Mark your calendars for July 21st, as the next Dr. Carbon dioxide-induced decrease in extracellular pH enhances the production of extracellular matrix components Structure, Mechanism, and Drug Interactions of GPCRs, Ion Channels, and Transport Proteins (March 24

December 2021 "Dame Carol Robinson DBE, FRS, FRSC, FMedSci, Oxford University’s first female Professor

October 2022 "G protein-coupled receptors (GPCRs) are important drug targets characterized by a canonical

GPCR Symposia Our first upcoming symposium on March 15th this year is about GPCR activation and signaling Targeted Drug Discovery Summit  Join us at the 3rd GPCRs Targeted Drug Discovery Summit in Boston on March BPS Annual Meeting NEW February 20, 2024 | Career Opportunities in Pharmacology and Drug Discovery March 13 - 15 | 9th German Pharm-Tox Summit March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 1 - 4, 2024 |

GPCR Partnered Events March 5 - 7, 2024 | 3rd GPCRs - Targeted Drug Discovery Summit  We're partnering again with the 3rd GPCRs - Targeted Drug Discovery Summit in Boston on March 5-7, 2024. SLAS2024 International Conference and Exhibition February 11 - 14, 2024 | 2024 BPS Annual Meeting NEW March 13 - 15 | 9th German Pharm-Tox Summit March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 1 - 4, 2024 |

Deadline extended to March 31st, 2023. GPCR Events, Meetings, and Webinars SLAS2023 International Conference and Exhibition (February 25 - March (February 20 - March 3, 2023). (March 2, 2023) GEM2023. (March 14-17, 2023). SLAS 2023 B Building Biology in 3D Symposium.

Deadline extended to March 31st, 2023. SLAS2023 International Conference and Exhibition (February 25 - March 1, 2023). 2nd ERNEST Training School (February 20 - March 3, 2023). (March 2, 2023) GEM2023. (March 14-17, 2023). SLAS 2023 B Building Biology in 3D Symposium.

March 2022 "March 3, 2022 Susanna Naggie, MD, and Sudarshan Rajagopal, MD, PhD Two School of Medicine

Aaron McGrath from Takeda. He joins Dr. pockets and druggability 🔹 The role of cryo-EM in capturing fully activated GPCR complexes 📅 Catch Aaron

S., Caron, M. G., Lefkowitz, R. J., & Strader, C. D. (1986).

October 2022 "The canonical model for G protein-coupled receptors (GPCRs) activation assumes that stimulation

Here, we determine that GRKs phosphorylate a non-canonical substrate, anterior pharynx-defective 1A (

March 2022 Crinetics Pharmaceuticals Expands Executive Team With Appointment Of James Hassard As Chief Commercial Officer "SAN DIEGO – March 1, 2022 – Crinetics Pharmaceuticals, Inc.

various cellular processes such as cell proliferation, migration, apoptosis, and transcription via canonical

March 2022 Inversago Pharma Announces Dosing of First Participant with Metabolic Syndrome in Phase 1B Clinical Trial "MONTREAL (CANADA) – March 15, 2022 – Inversago Pharma Inc.

March 2022 "Explicyte grants Domain Therapeutics exclusivity on data related to GPCR implicated in immunoresistance Strasbourg and Bordeaux, France, March 10, 2022 – Domain Therapeutics, a biopharmaceutical company specializing

Industry News Arcoscreen selected by START Lausanne to pitch at the START Global summit on the 23-24th March GPCR-Targeted Drug Discovery Summit | February 21-23, Boston. 2nd ERNEST Training School – February 20th to March GEM2023 (14-17 March 2023). 8th and final ERNEST Meeting May 3-7, 2023 in Crete.

GPCR contributor article Canonical chemokine receptors as scavenging “decoys” Shivani Sachdev, Brendan nanobody tethering Mechanistic insights into G-protein activation via phosphorylation mediated non-canonical

various cellular processes such as cell proliferation, migration, apoptosis, and transcription via canonical

| SLAS2024 International Conference and Exhibition February 11 - 14, 2024 | 2024 BPS Annual Meeting March 5 - 7, 2024 | 3rd GPCRs - Targeted Drug Discovery Summit March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April

February 16 - 21, 2025 | Harnessing the Power of Advanced Multimodal Approaches to GPCR Drug Discovery March 12 - 14, 2025 | NextGen Biomed 2025 March 25 - 28, 2025 | 10th German Pharm-Tox Summit April 1 - 5,