Search Results
Results found for "cryo-EM"
- 📰 GPCR Weekly News - January 9 to 15, 2023
You can always adjust your email preferences in your account settings. Protease-activated receptor 2 (PAR2)-targeting peptide derivatives for positron emission tomography ( Cryo-EM structures of orphan GPR21 signaling complexes.
- Mechanism vs. Assumption: A Model-First Path to Getting GPCR MoA Right
structural biology is teaching us about shallow orthosteric pockets and druggability 🔹 The role of cryo-EM
- 📰 GPCR Weekly News, March 20 to 26, 2023
New insights into GPCR coupling and dimerisation from cryo-EM structures.
- 📰 GPCR Weekly News, September 18 to 24, 2023
Registration is now closed, but you can join the waitlist by emailing gpcrretreat@uottawa.ca. structure, and function of 5-HTR1E serotonin receptor Structural and Molecular Insights into GPCR Function Cryo-EM
- 📰 GPCR Weekly News, September 4 to 10, 2023
Drugs, and more Saturated Cannabinoids: Update on Synthesis Strategies and Biological Studies of These Emerging September 21, 2023 | Breaking Through the Barriers: Unlocking the Future of Ion Channel Drug Discovery with Cryo-EM
- 📰 GPCR Weekly News, August 28 to September 3, 2023
Landscape of the Molecule Focused classifications and refinements in high-resolution single particle cryo-EM
- 📰 GPCR Weekly News, April 24 to 30, 2023
Structural and Molecular Insights into GPCR Function Cryo-EM structure of the endothelin-1-ETB-Gi complex
- Structural landscape of the Chemokine Receptor system
Thanks to advancements in cryo-electron microscopy (cryo-EM) technology, there has been a rapid increase Experimental 3D structures of both receptors reveal that they employ distinct mechanisms for constitutive Recent advancements in cryo-EM technology have led to a rapid increase in the number of experimental As more experimental structures of CKRs continue to emerge, it is expected that a more detailed understanding
- GPCR Buzz of the Week | Sep 23 - 29, 2024
Emerging Voices in GPCR Biology in Special Issue of Molecular Pharmacology GPCR Events, Meetings, and receptor variations in the Japanese population 54KJPN Structural and Molecular Insights into GPCR Function Cryo-EM
- 📰 GPCR Weekly News, January 22 to 28, 2024
Please email us at Hello@DrGPCR.com if you want to share your work with our community. If you are interested in applying, please email us your CV/Resume at Hello@DrGPCR.com. Dr. in Fallopian Tubes and Drug Design Structural and Molecular Insights into GPCR Function Optimizing cryo-EM
- 📰 GPCR Weekly News, July 1 to 7, 2024
mutations in G protein-coupled receptors may contribute to autism GPCRs in Oncology and Immunology Emerging CXV: The Class F of G Protein-Coupled Receptors Structural and Molecular Insights into GPCR Function Cryo-EM
- 📰 GPCR Weekly News, May 13 to 19, 2024
If you're interested in sponsoring, please email us at Hello@DrGPCR.com. development of a Gα12/13-coupled designer GPCR GPR160 regulates the self-renewal and pluripotency of mouse embryonic Insights into GPCR Function A homotrimeric GPCR architecture of the human cytomegalovirus revealed by cryo-EM
- 📰 GPCR Weekly News, May 29 to June 4, 2023
If you'd like to showcase your work, please email us at Hello@DrGPCR.com. New insights into GPCR coupling and dimerisation from cryo-EM structures.
- 📰 GPCR Weekly News
Emerging approaches for decoding neuropeptide transmission. Cryo-EM structure of G-protein-coupled receptor GPR17 in complex with inhibitory G protein.
- Exciting GPCR Events for Next Year! + GPCR Weekly Rocket Launch ⦿ Oct 28 - Nov 3, 2024
into GPCR Function Native mass spectrometry prescreening of G protein-coupled receptor complexes for cryo-EM
- 📰 GPCR Weekly News, March 27 to April 4, 2023
The program is under construction but if you’d like to give a talk or present a poster, email us at Hello The impact of cryo-EM on determining allosteric modulator-bound structures of G protein-coupled receptors
- 📰 GPCR Weekly News, January 30 to February 5, 2023
You can always adjust your email preferences in your account settings. For Dr. Cryo-EM structure of orphan G protein-coupled receptor GPR21.
- The Perils and Guardrails of Modifying Signalling Proteins in Bioassays
The authors emphasise the importance of understanding the advantages and limitations of different assay EMBO Rep. 2017;18(9):1493-1496. 16. Melancon BJ, Hopkins CR, Wood MR, Emmitte KA, Niswender CM, Christopoulos A, et al. Seven transmembrane receptors as nature's prototype allosteric protein: de-emphasizing the geography Cryo-EM structures of GPCRs coupled to Gs, Gi and Go.
- Structural view of G protein-coupled receptor signaling in the retinal rod outer segment
We have combined recently published cryo-electron tomography (cryo-ET) data on the ROS with structural
- 📰 GPCR Weekly Buzz: Exciting Schedule Shifts for Principles of Pharmacology I & II | August 12-18, 2024
subtype selectivity of kisspeptin receptor Structural analysis of the human C5a-C5aR1 complex using cryo-electron microscopy Structural analysis of the human C5a-C5aR1 complex using cryo-electron microscopy Industry Postdoctoral Position Postdoctoral research position Senior or Lead Researcher Senior Scientist, Cryo-Electron
- Decoding GPCR Function: The Role of Mutagenesis in Rational Drug Discovery
Notably, innovations in structural biology, such as X-ray crystallography and cryo-electron microscopy In this context, mutagenesis has emerged as an "old-school" but essential technology to fill these knowledge While advancements in structural biology techniques like X-ray crystallography and cryo-electron microscopy
- Structure of the vasopressin hormone-V2 receptor-β-arrestin1 ternary complex
Here, we report the cryo-electron microscopy active structure of the wild-type arginine-vasopressin V2
- Activation of the human chemokine receptor CX3CR1 regulated by cholesterol
Here, we present two cryo-electron microscopy structures of CX3CR1-Gi1 complexes in ligand-free and CX3CL1
- G protein coupling and activation of the metabotropic GABAB heterodimer
Cryo-electron microscopy studies revealed a drastic conformational change upon activation and a unique
- Molecular mechanism of allosteric modulation for the cannabinoid receptor CB1
Here, we report the crystallographic and cryo-electron microscopy structures of the cannabinoid receptor
- Structural basis of adhesion GPCR GPR110 activation by stalk peptide and G-proteins coupling
Here, we report the cryo-electron microscopy structures of GPR110 (ADGRF1), a member of aGPCR, in complex
- Enhancing GPCR Research Outreach | Dr GPCR University early-bird registration ends soon!
Postdoctoral Position Postdoctoral research position Senior or Lead Researcher Senior Scientist, Cryo-Electron
- Embark on a GPCR Adventure: Your Weekly Research Expedition! | Oct 21-27, 2024
Embark on another exciting exploration of the unknown realms of GPCR research. Emerging Voices in GPCR Biology in Special Issue of Molecular Pharmacology GPCR Events, Meetings, and
- TM5-TM6: structural switches that modulate the coupling of serotonin receptors to Gs or Gi
Through Cryo-Electron Microscopy, authors reported the structures of four protein complexes integrated
- 📰 GPCR Weekly News, May 27 to June 2, 2024
Please email us at Hello@DrGPCR.com. India Methods & Updates in GPCR Research Engineering G protein-coupled receptors for stabilization Cryo-electron











