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But Sokhom Pin stayed loyal to GPCRs , even when big pharma turned its gaze to other targets like kinases

At Alkermes , Sokhom Pin wasn’t just leading GPCR programs; he was building culture from the ground up

Pina Cardarelli, CSO of GPCR Therapeutics.

That’s exactly what Sokhom Pin did. Takeaway If you’re navigating work, life, and scientific ambition, Sokhom Pin proves it’s possible to

extracellular domain, which contains the hormone-binding site and is linked to the transmembrane domain by the hinge

HLGR2 RNAi led to a low pupation rate (45.00%), body malformation, abnormal wing expansion, failed cuticle Conclusion: HLGR2 is essential for the growth and development and wing expansion and maturation in H.

significance of GPR39 was evaluated by analyzing the correlations with clinicopathological factors with the chi-square

OXFORD, England--Professor Charlotte Deane, Ph.D., of the University of Oxford, has joined Exscientia as Chief Professor Deane joins Exscientia’s technology leadership team, reporting to Chief Technology Officer,

Vraniak to the position of Chief Financial Officer (CFO), effective immediately. Mr. Vraniak served as Chief Financial Officer of Evaxion Biotech A/S, an AI enabled immuno-oncology company Vraniak served as the Chief Financial Officer of electroCore, Inc. and was a key member of the management

Law, our newly named Chief Business Officer.

March 2022 Crinetics Pharmaceuticals Expands Executive Team With Appointment Of James Hassard As Chief endocrine diseases and endocrine-related tumors, today announced the appointment of James Hassard as chief

February 2022 Trevena Announces Submission of New Drug Application in China for OLINVYK® by its Partner by data from a Phase 3 bridging study of oliceridine injection compared to IV morphine, conducted in China success payments upon approval and commercialization milestones, as well as a 10% royalty on net sales in China commercialization of novel medicines for patients with central nervous system (CNS) disorders, today announced that China

Ping, Y.-Q., et al., Structural basis for the tethered peptide activation of adhesion GPCRs.

2022 Identification and functional characterization of the sulfakinin and sulfakinin receptor in the Chinese white pine beetle Dendroctonus armandi "The sulfakinin (SK) is an important signal molecule. However, there is no report on the functional role of SK in the Chinese white pine beetle, Dendroctonus

October 2022 "Melanocortin 3 receptor (MC3R) is a G-protein coupled receptor (GPCR) that is defined as a regulator of appetite/hunger balance mechanisms mostly up to date. In addition to its function about weight gain and appetite control mechanisms of MC3R, recent studies showed that MC3R controls growth, puberty, and circadian rhythms as well. Despite the drastic effects of the MC3R deficiency in humans and other mammals, its cellular mechanisms are still under investigation. In this review paper, we aimed to point out the importance of the MC3R regulations in three main concepts: 1) its impact on weight and appetite control, 2) the control of growth, puberty, and circadian rhythm, and, 3) its protein-protein interactions and cellular mechanisms." Read more at the source #DrGPCR #GPCR #IndustryNews

Graeme Milligan for receiving the Order of British Empire from King Charles III in recognition of his Graeme Milligan was awarded the Order of British Empire by King Charles III for services to Biochemical

approach to this problem by predicting potential resistance mutations before they are clinically observed (Pines BioRxiv (Cold Spring Harbor Laboratory) . https://doi.org/10.1101/2024.04.17.590000 Pines, G., Fankhauser

Expectations, EPS Lags “As Precision Medicine is critical, we cannot think about one size fits all” Dr Pina Cardarelli, Chief Scientific Officer, GPCR Therapeutics Trevena to Participate in Three Upcoming Conferences

Devki D Sukhtankar and Pina M Cardarelli's research: Burixafor Hydrobromide (GPC-100) effects on hematopoietic Christophe Arbet-Engels to Join as Chief Medical Officer GPCR Events, Meetings, and Webinars ONCORNET2.0

Netherlands: Dordrecht, 2014; pp 55–74. https://doi.org/10.1007/978-94-007-7423-0_4 . (12)      Yung-Chi

New Tools for Getting Drugs Inside Cells All of this hinges on a simple question: can your compound get

data into insights for drug discovery Hi GPCR Friends, Every week, critical decisions in GPCR research hinge

The Neuromedin U system: pharmacological implications for the treatment of obesity and binge eating behavior

A rational drug discovery campaign hinges on a deep understanding of how distinct molecules interact

Industry News Josephine (Pina) Cardarelli from GPCR Therapeutics on Beyond Biotech Podcast Crinetics

Morgan Healthcare Conference Andrew Hopkins appointed CBE by HM King Charles III Voyager Therapeutics

Secure Your Spot for the October 30 AMA Why Terry’s Corner The efficiency of your pipeline doesn’t hinge

the observed phenotype since many glycosyltransferases and the two TPSTs also carry O-glycosylation (King

states: methods and implications The formation of functional complexes involving GPCRs and β-arrestins hinges

calcium-binding photoprotein clytin II: Expression of the preferred human codon-optimized clytin II gene in Chinese