GPCR NewsDec 1, 20211 minGPCR Activation and SignalingFree-Energy Simulations Support a Lipophilic Binding Route for Melatonin Receptors"The effects of the neurohormone melatonin are mediated by the activation of the GPCRs MT1 and MT2 in a variety of tissues. Crystal...
GPCR NewsDec 1, 20211 minGPCR Activation and SignalingDisentangling bias between G q, GRK2, and arrestin3 recruitment to the M 3 muscarinic acetylcholine G protein-coupled receptors (GPCRs) transmit extracellular signals to the inside by activation of intracellular effector proteins....
GPCR NewsDec 1, 20211 minGPCR Activation and SignalingRescue of Cell Surface Expression and Signaling of Mutant Follicle-Stimulating Hormone ReceptorsMutations in G protein-coupled receptors (GPCRs) underlie numerous diseases. Many cause receptor misfolding and failure to reach the cell...