Insights That Move the GPCR Field Forward

Biased signaling is often interpreted through receptor conformations, yet selectivity can also emerge from the stabilization of receptor–transducer complexes. System-dependent variability adds a further layer: signaling profiles shift when biological context changes. This week’s sessions examine both.

Classic models explain biased GPCR signaling through ligands that stabilize distinct receptor conformations and thereby favor selective transducer interactions. This remains a powerful framework, but the examples highlighted this week point to an additional route: intracellular modulators that bind at receptor–transducer interfaces, alongside experimental systems that place GPCR signaling in more physiological cellular contexts.