Search Results
Results found for "Lauren T May"
- First AMA of 2026: GPCR Pharmacology, Biased Signaling & Mechanistic Clarity
What appears settled under one experimental condition may require refinement under another. Terry’s Pharmacology Corner provides a structured environment to maintain interpretive discipline: Weekly
- 📰 GPCR Weekly News, October 23 to 29, 2023
2024 | Ligand Recognition and Molecular Gating Conference April 5 - 10, 2024 | AACR Annual Meeting May 13 - 17, 2024 | 20th Annual PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS
- Your GPCR Program Decisions Depend on Good Data Interpretation
Under certain experimental conditions, what appears to be a second high-affinity site may simply reflect GPCR University Learner Celtarys Research Recap: Medicinal Chemistry Highlights You May Have Missed The
- Targeting GPCRs in the CNS: Advances in Drug Discovery Strategies
The conformation change induced by the agonist may not always lead to the same intracellular signaling Studying these routes may reduce side-effects when using GPCR-based therapies.
- Gαs and Gαq/11 protein coupling bias of two AVPR2 mutants (R68W and V162A) that cause nephrogenic di
AVPR2 is a kind of G protein coupled receptor (GPCR) and mainly couples with Gαs protein leading to cAMP Investigation into the characterization of biased receptors may give insights into the relationship between Studies about the Gα protein coupling bias of mutant AVPR2s may broaden our understanding of the relationship between the changed conformation of the receptor and consequently activated signaling pathways, and also may
- Why Opposing Processes Matter for Your Next GPCR Drug
Ignore these forces, and your “selective” agonist may deliver surprises the first time it meets a patient Get a sense of why inverse agonists may be necessary to truly shift the physiological balance.
- 📰 GPCR Weekly News, December 4 to 10, 2023
Physiology Summit April 5 - 10, 2024 | AACR Annual Meeting April 22 - 23, 2024 | Endocrine Metabolic GPCRs May 13 - 17, 2024 | 20th Annual PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS
- 📰 GPCR Weekly News, February 5 to 11, 2024
Discovery Chemistry April 4 - 7, 2024 | American Physiology Summit April 5 - 10, 2024 | AACR Annual Meeting May 13 - 17, 2024 | 20th Annual PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS
- 📰 GPCR Weekly News, October 16 to 22, 2023
2024 | Ligand Recognition and Molecular Gating Conference April 5 - 10, 2024 | AACR Annual Meeting May 13 - 17, 2024 | 20th Annual PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS
- 📰 GPCR Weekly News, February 13 to 19, 2023
GPCRs, and more Single nucleotide variations encoding missense mutations in G protein-coupled receptors may (May 22 - 26, 2023) 2nd LEAPS Meets Life Sciences Conference. (May 14 - 19, 2023) 8th and final ERNEST Meeting in Crete. (May 3 - 7, 2023).
- GPCR Collaboration: From Models to Medicine
Structural biologists may capture snapshots of receptor conformations, but lack large-scale screening Overstating the precision of a model or the predictive power of an assay may look persuasive in the short
- The Quiet Power of RGS Proteins: Rethinking Pain Pathways through GPCR Biology
The real power may lie in how they’re regulated. Dr.
- Assay Sensitivity: The Hidden Lever Driving GPCR Drug Discovery
A drug candidate that looks promising in a high-sensitivity assay may collapse under physiological stress Conversely, a weak signal in a baseline assay may mask an opportunity—if the system were tuned differently
- 📰 GPCR Weekly News, January 8 to 14, 2024
Discovery Chemistry April 4 - 7, 2024 | American Physiology Summit April 5 - 10, 2024 | AACR Annual Meeting May 13 - 17, 2024 | 20th Annual PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS
- 📰 GPCR Weekly News, January 1 to 7, 2024
Adhesion GPCRs The adhesion G-protein-coupled receptor mayo/CG11318 controls midgut development in Drosophila Physiology Summit April 5 - 10, 2024 | AACR Annual Meeting April 22 - 23, 2024 | Endocrine Metabolic GPCRs May 13 - 17, 2024 | 20th Annual PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS
- From Snapshots to Predictions: Why Mechanism of Action Matters
In discovery, different pathways may look identical at first glance. If you stop at potency, structure–activity relationships (SARs) may look flat.
- 📰 GPCR Weekly News, August 21 to 27, 2023
Ligand Recognition and Molecular Gating Conference NEW April 5 - 10, 2024 | AACR Annual Meeting NEW May 13 - 17, 2024 | 20th Annual PEGS Boston Summit NEW May 16 - 19, 2024 | ASPET 2024 NEW May 27 - 29, 2024
- 📰 GPCR Weekly News, February 12 to 18, 2024
Discovery Chemistry April 4 - 7, 2024 | American Physiology Summit April 5 - 10, 2024 | AACR Annual Meeting May 13 - 17, 2024 | 20th Annual PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS
- 📰 GPCR Weekly News, September 18 to 24, 2023
2024 | Ligand Recognition and Molecular Gating Conference April 5 - 10, 2024 | AACR Annual Meeting May 13 - 17, 2024 | 20th Annual PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS
- 📰 GPCR Weekly News, November 20 to 26, 2023
Or maybe looking for your next opportunity? Let Mark Schmeizl, our Chief Matchmaker help. Strategy through Molecular Modeling Studies and Biological Assays GPCRs in Oncology and Immunology RGS5 maintaining Physiology Summit April 5 - 10, 2024 | AACR Annual Meeting April 22 - 23, 2024 | Endocrine Metabolic GPCRs May 13 - 17, 2024 | 20th Annual PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS
- What's Going On with GPCRs?! Find Out in This Week's Update! ⦿ Nov 4 - 10, 2024
April 24 - 27, 2025 | American Physiology Summit 2025 April 25 - 30, 2025 | AACR Annual Meeting 2025 May 12 - 15, 2025 | PEGS 2025 May 20 - 22, 2025 | SLAS Europe 2025 June 16 - 19, 2025 | BIO International
- 📰 GPCR Weekly News, September 4 to 10, 2023
2024 | Ligand Recognition and Molecular Gating Conference April 5 - 10, 2024 | AACR Annual Meeting May 13 - 17, 2024 | 20th Annual PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS
- Understanding Orthosteric Binding: The Key to Drug Action
The receptor may change shape upon binding, affecting how the drug interacts and how effective it will
- 📰 GPCR Weekly News, January 22 to 28, 2024
Discovery Chemistry April 4 - 7, 2024 | American Physiology Summit April 5 - 10, 2024 | AACR Annual Meeting May 13 - 17, 2024 | 20th Annual PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS
- 📰 GPCR Weekly News, February 20 to 26, 2023
Sometimes we may miss publications. (May 22 - 26, 2023) 2nd LEAPS Meets Life Sciences Conference. (May 14 - 19, 2023) 8th and final ERNEST Meeting in Crete. (May 3 - 7, 2023).
- Primary cilia and SHH signaling impairments in human and mouse models of Parkinson’s disease
Thus, increased SHH activity due to ciliary dysfunction may be required for the development of pathoetiological Inhibiting overactive SHH signaling may be a potential neuroprotective therapy for sPD."
- 📰 GPCR Weekly News, August 28 to September 3, 2023
2024 | Ligand Recognition and Molecular Gating Conference April 5 - 10, 2024 | AACR Annual Meeting May 13 - 17, 2024 | 20th Annual PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS
- 📰 GPCR Weekly News, January 15 to 21, 2024
Discovery Chemistry April 4 - 7, 2024 | American Physiology Summit April 5 - 10, 2024 | AACR Annual Meeting May 13 - 17, 2024 | 20th Annual PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS
- The Real Cost of Strategic Overload in Biotech
The scientific ambition may be impressive, yet the strategic narrative loses sharpness. That decline may not disrupt daily operations, but it quietly weakens positioning long before biotech What did you decide not to pursue to strengthen the main thesis?
- 📰 GPCR Weekly News, December 18 to 31, 2023
Physiology Summit April 5 - 10, 2024 | AACR Annual Meeting April 22 - 23, 2024 | Endocrine Metabolic GPCRs May 13 - 17, 2024 | 20th Annual PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS
