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- Targeting GPCRs in the CNS: Advances in Drug Discovery Strategies
The conformation change induced by the agonist may not always lead to the same intracellular signaling Studying these routes may reduce side-effects when using GPCR-based therapies.
- 📰 GPCR Weekly News, February 13 to 19, 2023
GPCRs, and more Single nucleotide variations encoding missense mutations in G protein-coupled receptors may (May 22 - 26, 2023) 2nd LEAPS Meets Life Sciences Conference. (May 14 - 19, 2023) 8th and final ERNEST Meeting in Crete. (May 3 - 7, 2023).
- 📰 GPCR Weekly News, December 4 to 10, 2023
Physiology Summit April 5 - 10, 2024 | AACR Annual Meeting April 22 - 23, 2024 | Endocrine Metabolic GPCRs May 13 - 17, 2024 | 20th Annual PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS
- Why Opposing Processes Matter for Your Next GPCR Drug
Ignore these forces, and your “selective” agonist may deliver surprises the first time it meets a patient Get a sense of why inverse agonists may be necessary to truly shift the physiological balance.
- 📰 GPCR Weekly News, October 16 to 22, 2023
2024 | Ligand Recognition and Molecular Gating Conference April 5 - 10, 2024 | AACR Annual Meeting May 13 - 17, 2024 | 20th Annual PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS
- 📰 GPCR Weekly News, February 5 to 11, 2024
Discovery Chemistry April 4 - 7, 2024 | American Physiology Summit April 5 - 10, 2024 | AACR Annual Meeting May 13 - 17, 2024 | 20th Annual PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS
- The Quiet Power of RGS Proteins: Rethinking Pain Pathways through GPCR Biology
The real power may lie in how they’re regulated. Dr.
- GPCR Collaboration: From Models to Medicine
Structural biologists may capture snapshots of receptor conformations, but lack large-scale screening Overstating the precision of a model or the predictive power of an assay may look persuasive in the short
- 📰 GPCR Weekly News, January 8 to 14, 2024
Discovery Chemistry April 4 - 7, 2024 | American Physiology Summit April 5 - 10, 2024 | AACR Annual Meeting May 13 - 17, 2024 | 20th Annual PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS
- 📰 GPCR Weekly News, January 1 to 7, 2024
Adhesion GPCRs The adhesion G-protein-coupled receptor mayo/CG11318 controls midgut development in Drosophila Physiology Summit April 5 - 10, 2024 | AACR Annual Meeting April 22 - 23, 2024 | Endocrine Metabolic GPCRs May 13 - 17, 2024 | 20th Annual PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS
- Assay Sensitivity: The Hidden Lever Driving GPCR Drug Discovery
A drug candidate that looks promising in a high-sensitivity assay may collapse under physiological stress Conversely, a weak signal in a baseline assay may mask an opportunity—if the system were tuned differently
- 📰 GPCR Weekly News, August 21 to 27, 2023
Ligand Recognition and Molecular Gating Conference NEW April 5 - 10, 2024 | AACR Annual Meeting NEW May 13 - 17, 2024 | 20th Annual PEGS Boston Summit NEW May 16 - 19, 2024 | ASPET 2024 NEW May 27 - 29, 2024
- Primary cilia and SHH signaling impairments in human and mouse models of Parkinson’s disease
Thus, increased SHH activity due to ciliary dysfunction may be required for the development of pathoetiological Inhibiting overactive SHH signaling may be a potential neuroprotective therapy for sPD."
- 📰 GPCR Weekly News, September 18 to 24, 2023
2024 | Ligand Recognition and Molecular Gating Conference April 5 - 10, 2024 | AACR Annual Meeting May 13 - 17, 2024 | 20th Annual PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS
- 📰 GPCR Weekly News, February 12 to 18, 2024
Discovery Chemistry April 4 - 7, 2024 | American Physiology Summit April 5 - 10, 2024 | AACR Annual Meeting May 13 - 17, 2024 | 20th Annual PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS
- From Snapshots to Predictions: Why Mechanism of Action Matters
In discovery, different pathways may look identical at first glance. If you stop at potency, structure–activity relationships (SARs) may look flat.
- 📰 GPCR Weekly News, February 20 to 26, 2023
Sometimes we may miss publications. (May 22 - 26, 2023) 2nd LEAPS Meets Life Sciences Conference. (May 14 - 19, 2023) 8th and final ERNEST Meeting in Crete. (May 3 - 7, 2023).
- 📰 GPCR Weekly News, November 20 to 26, 2023
Or maybe looking for your next opportunity? Let Mark Schmeizl, our Chief Matchmaker help. Strategy through Molecular Modeling Studies and Biological Assays GPCRs in Oncology and Immunology RGS5 maintaining Physiology Summit April 5 - 10, 2024 | AACR Annual Meeting April 22 - 23, 2024 | Endocrine Metabolic GPCRs May 13 - 17, 2024 | 20th Annual PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS
- 📰 GPCR Weekly News, September 4 to 10, 2023
2024 | Ligand Recognition and Molecular Gating Conference April 5 - 10, 2024 | AACR Annual Meeting May 13 - 17, 2024 | 20th Annual PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS
- 📰 GPCR Weekly News, August 28 to September 3, 2023
2024 | Ligand Recognition and Molecular Gating Conference April 5 - 10, 2024 | AACR Annual Meeting May 13 - 17, 2024 | 20th Annual PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS
- 📰 GPCR Weekly News, January 22 to 28, 2024
Discovery Chemistry April 4 - 7, 2024 | American Physiology Summit April 5 - 10, 2024 | AACR Annual Meeting May 13 - 17, 2024 | 20th Annual PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS
- 📰 GPCR Weekly News, January 15 to 21, 2024
Discovery Chemistry April 4 - 7, 2024 | American Physiology Summit April 5 - 10, 2024 | AACR Annual Meeting May 13 - 17, 2024 | 20th Annual PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS
- Platelets in the NETworks interweaving inflammation and thrombosis
Platelet α-granules contain microbicidal proteins, chemokines and growth factors, which upon release may negatively charged DNA within NETs provides a procoagulant surface, and in particular NET-derived proteins may Here, virus infiltration may lead to a cytokine storm that potently activates neutrophils and leads to
- What's Going On with GPCRs?! Find Out in This Week's Update! ⦿ Nov 4 - 10, 2024
April 24 - 27, 2025 | American Physiology Summit 2025 April 25 - 30, 2025 | AACR Annual Meeting 2025 May 12 - 15, 2025 | PEGS 2025 May 20 - 22, 2025 | SLAS Europe 2025 June 16 - 19, 2025 | BIO International
- Domain Therapeutics Raises $42m Series A Financing
May 2022 "Published: May 10, 2022 To accelerate clinical development of its best-in-class and first-in-class
- Functional modulation of PTH1R activation and signaling by RAMP2
However, it is unknown whether and how RAMP proteins may affect PTH1R function. These data uncover a critical role of RAMPs in the activation and signaling of a GPCR that may provide
- Understanding Orthosteric Binding: The Key to Drug Action
The receptor may change shape upon binding, affecting how the drug interacts and how effective it will
- 📰 GPCR Weekly News, December 18 to 31, 2023
Physiology Summit April 5 - 10, 2024 | AACR Annual Meeting April 22 - 23, 2024 | Endocrine Metabolic GPCRs May 13 - 17, 2024 | 20th Annual PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS
- 📰 GPCR Weekly News, December 11 to 17, 2023
Physiology Summit April 5 - 10, 2024 | AACR Annual Meeting April 22 - 23, 2024 | Endocrine Metabolic GPCRs May 13 - 17, 2024 | 20th Annual PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS
- Orion Shares New Data on its Latest Best-in-Class Drug Candidate
June 2022 "Ottawa, Canada, May 10, 2022 — Orion Biotechnology Canada Ltd, a drug discovery and development important new data at both LSX World Congress and TIDES USA 2022 conference, taking place this week – May
