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Mark your calendar; we’re planning a workshop for May 2024 with Dr. Sam Hoare as our instructor. Discovery Chemistry April 4 - 7, 2024 | American Physiology Summit April 5 - 10, 2024 | AACR Annual Meeting May 13 - 17, 2024 | 20th Annual PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS

Procrastination may seem tempting, but tackling your work incrementally will save time and reduce stress The road may be long, and challenges will test your resolve, but every small victory along the way shapes

Hello GPCR Colleagues and Collaborators, We’re diving into May with serious momentum.

GPCR Symposium on GPCR Activation and Signaling on May 19th, 2023. Meetings, and Webinars ASPET 2023 - American Society for Pharmacology and Experimental Therapeutics (May (May 22 - 26, 2023) 2nd LEAPS Meets Life Sciences Conference. (May 14 - 19, 2023) NEW PEGS Boston (May 15 - 19, 2023) 8th and final ERNEST Meeting in Crete. (May 3 - 7, 2023). The Illuminating the Understudied Druggable Proteome Conference.

2024 | Ligand Recognition and Molecular Gating Conference April 5 - 10, 2024 | AACR Annual Meeting May 13 - 17, 2024 | 20th Annual PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS

April 24 - 27, 2025 | American Physiology Summit 2025 April 25 - 30, 2025 | AACR Annual Meeting 2025 May 12 - 15, 2025 | PEGS 2025 May 20 - 22, 2025 | SLAS Europe 2025 June 16 - 19, 2025 | BIO International

GPCR Symposium on GPCR Activation and Signaling held on May 19th, 2023. April 24 - 25, 2023) NEW ASPET 2023 - American Society for Pharmacology and Experimental Therapeutics (May (May 22 - 26, 2023) 2nd LEAPS Meets Life Sciences Conference. (May 14 - 19, 2023) 8th and final ERNEST Meeting in Crete. (May 3 - 7, 2023).

What appears settled under one experimental condition may require refinement under another. Terry’s Pharmacology Corner provides a structured environment to maintain interpretive discipline: Weekly

2024 | Ligand Recognition and Molecular Gating Conference April 5 - 10, 2024 | AACR Annual Meeting May 13 - 17, 2024 | 20th Annual PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS

GPCR Symposium on GPCR Activation and Signaling on May 19th, 2023. (April 24 - 25, 2023) ASPET 2023 - American Society for Pharmacology and Experimental Therapeutics (May (May 22 - 26, 2023) 2nd LEAPS Meets Life Sciences Conference. (May 14 - 19, 2023) 8th and final ERNEST Meeting in Crete. (May 3 - 7, 2023).

Under certain experimental conditions, what appears to be a second high-affinity site may simply reflect GPCR University Learner Celtarys Research Recap: Medicinal Chemistry Highlights You May Have Missed The

2024 | Ligand Recognition and Molecular Gating Conference April 5 - 10, 2024 | AACR Annual Meeting May 13 - 17, 2024 | 20th Annual PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS

The conformation change induced by the agonist may not always lead to the same intracellular signaling Studying these routes may reduce side-effects when using GPCR-based therapies.

Ignore these forces, and your “selective” agonist may deliver surprises the first time it meets a patient Get a sense of why inverse agonists may be necessary to truly shift the physiological balance.

Structural biologists may capture snapshots of receptor conformations, but lack large-scale screening Overstating the precision of a model or the predictive power of an assay may look persuasive in the short

A structural modification that appears to reduce affinity may instead be shifting receptor populations A cell line with limited coupling capacity may suppress the formation of key receptor states, masking

The real power may lie in how they’re regulated. Dr.

Physiology Summit April 5 - 10, 2024 | AACR Annual Meeting April 22 - 23, 2024 | Endocrine Metabolic GPCRs May 13 - 17, 2024 | 20th Annual PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS

AVPR2 is a kind of G protein coupled receptor (GPCR) and mainly couples with Gαs protein leading to cAMP Investigation into the characterization of biased receptors may give insights into the relationship between Studies about the Gα protein coupling bias of mutant AVPR2s may broaden our understanding of the relationship between the changed conformation of the receptor and consequently activated signaling pathways, and also may

Discovery Chemistry April 4 - 7, 2024 | American Physiology Summit April 5 - 10, 2024 | AACR Annual Meeting May 13 - 17, 2024 | 20th Annual PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS

A drug candidate that looks promising in a high-sensitivity assay may collapse under physiological stress Conversely, a weak signal in a baseline assay may mask an opportunity—if the system were tuned differently

2024 | Ligand Recognition and Molecular Gating Conference April 5 - 10, 2024 | AACR Annual Meeting May 13 - 17, 2024 | 20th Annual PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS

GPCRs, and more Single nucleotide variations encoding missense mutations in G protein-coupled receptors may (May 22 - 26, 2023) 2nd LEAPS Meets Life Sciences Conference. (May 14 - 19, 2023) 8th and final ERNEST Meeting in Crete. (May 3 - 7, 2023).

In discovery, different pathways may look identical at first glance. If you stop at potency, structure–activity relationships (SARs) may look flat.

Discovery Chemistry April 4 - 7, 2024 | American Physiology Summit April 5 - 10, 2024 | AACR Annual Meeting May 13 - 17, 2024 | 20th Annual PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS

Adhesion GPCRs The adhesion G-protein-coupled receptor mayo/CG11318 controls midgut development in Drosophila Physiology Summit April 5 - 10, 2024 | AACR Annual Meeting April 22 - 23, 2024 | Endocrine Metabolic GPCRs May 13 - 17, 2024 | 20th Annual PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS

Discovery Chemistry April 4 - 7, 2024 | American Physiology Summit April 5 - 10, 2024 | AACR Annual Meeting May 13 - 17, 2024 | 20th Annual PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS

The receptor may change shape upon binding, affecting how the drug interacts and how effective it will

Ligand Recognition and Molecular Gating Conference NEW April 5 - 10, 2024 | AACR Annual Meeting NEW May 13 - 17, 2024 | 20th Annual PEGS Boston Summit NEW May 16 - 19, 2024 | ASPET 2024 NEW May 27 - 29, 2024

April 24 - 27, 2025 | American Physiology Summit 2025 April 25 - 30, 2025 | AACR Annual Meeting 2025 May 12 - 15, 2025 | PEGS 2025 May 20 - 22, 2025 | SLAS Europe 2025 June 16 - 19, 2025 | BIO International