Targeting Intracellular Allosteric Sites in GPCRs
Exploring the intracellular allosteric site GPCRs represent one of the largest and most vital families of cell surface receptors, playing...
Targeting Intracellular Allosteric Sites in GPCRs
Decoding β-Arrestins: from Structure to function
Structural landscape of the Chemokine Receptor system
Artificial intelligence – faster, smarter, cheaper GPCR drug discovery
VAMP2: a crucial player in the delivery of MOR to the synapse
Feeder or trigger – CCR2 as a scavenger and regulator of cell migration
Glyco-sulfo hotspots in the chemokine receptor system
Odorant receptors – a bit of smell for drug discovery
Transmembrane domains of GPCR dimers – a novel hot spot for drug discovery
Emerging approaches for decoding neuropeptide transmission
Location bias contributes to functionally selective responses of biased CXCR3 agonists
Deciphering the signaling mechanisms of β-arrestin1 and β-arrestin2 in regulation of cancer cell...
Structure-Based Discovery of Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5
Structural insights into adhesion GPCR ADGRL3 activation and Gq, Gs, Gi, and G12 coupling
Conservation of Allosteric Ligand Binding Sites in G-Protein Coupled Receptors
Dimerization of β2-adrenergic receptor is responsible for the constitutive activity subjected to inv
High hedgehog signaling is transduced by a multikinase-dependent switch controlling the...
Structure of the vasopressin hormone-V2 receptor-β-arrestin1 ternary complex
Dual loss of regulator of G protein signaling 2 and 5 exacerbates ventricular myocyte arrhythmias...
Mechanistic basis of GPCR activation explored by ensemble refinement of crystallographic structures